超高時間分解能検出器を用いた画像再構成不要陽電子放出イメージング

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Published in医学物理 Vol. 44; no. 2; pp. 29 - 35
Main Authors Berg, Eric, Kwon, Sun Il, 小川, 泉, 中島, 恭平, 橋本, 二三生, 玉川, 洋一, Cherry, Simon R, 大田, 良亮, 長谷川, 智之, 大村, 知秀
Format Journal Article
LanguageJapanese
Published 公益社団法人  日本医学物理学会 30.06.2024
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ISSN1345-5354
2186-9634
DOI10.11323/jjmp.44.2_29

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Author 玉川, 洋一
Berg, Eric
大村, 知秀
中島, 恭平
小川, 泉
橋本, 二三生
長谷川, 智之
Cherry, Simon R
Kwon, Sun Il
大田, 良亮
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  fullname: 小川, 泉
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  fullname: 橋本, 二三生
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  fullname: 玉川, 洋一
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  fullname: 長谷川, 智之
  organization: 北里大学医療衛生学部
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  fullname: 大村, 知秀
  organization: 浜松ホトニクス株式会社中央研究所
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References 6) Hashimoto F, Onishi Y, Ote K, et al.: Deep learning-based PET image denosing and reconstruction: A review. Radiol. Phys. Technol. 17: 24–46, 2024
19) Berg E, Cherry SR: Using convolutional neural networks to estimate time-of-flight from PET detector waveforms. Phys. Med. Biol. 63: 02LT01, 2018
16) Ota R, Nakajima K, Hasegawa T, et al.: Timing-performance evaluation of Cherenkov-based radiation detectors. Nucl. Inst. Meth. A 923: 1–4, 2019
12) Gundacker S, Auffray E, Pauwels K, et al.: Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Phys. Med. Biol. 61: 2802–2837, 2016
9) Surti S, Karp JS: Update on latest advances in time-of-flight PET. Phys. Med. 80: 251–258, 2020
13) Lecoq P, Auffray E, Brunner S, et al.: Factors influencing time resolution of scintillators and ways to improve them. IEEE Trans. Nucl. Sci. 57: 2411–2416, 2010
17) Ota R, Nakajima K, Ogawa I, et al.: Coincidence time resolution of 30 ps FWHM using a pair of Cherenkov-radiator-integrated MCP-PMTs. Phys. Med. Biol. 64: 07LT01, 2019
1) Kwon SI, Ota R, Berg E, et al.: Ultrafast timing enables reconstruction-free positron emission imaging. Nat. Photon. 15: 914–918, 2021
14) Brunner SE, Gruber L, Marton J, et al.: Studies on the Cherenkov efect for improved time resolution of TOF-PET. IEEE Trans. Nucl. Sci. 61: 443–447, 2014
20) Hendee, WR: Cross sectional medical imaging: A history. RadioGraphics 9: 1155–1180, 1989
11) Seifert S, van Dam HT, Schaart DR: The lower bound on the timing resolution of scintillation detectors. Phys. Med. Biol. 57: 1797–1814, 2012
18) Ota R, Nakajima K, Ogawa I, et al.: Lead-free MCP to improve coincidence time resolution and reduce MCP direct interactions. Phys. Med. Biol. 66: 064006, 2021
23) Onishi Y, Hashimoto F, Ote K, et al.: Whole reconstruction-free system design for direct positron emission imaging from image generation to attenuation correction. IEEE Trans. Med. Imag. 43: 1654–1663, 2024
2) Clackdoyle R, Defrise M: Tomographic reconstruction in the 21st Century. IEEE Signal Proc. Mag. 27: 60–80, 2010
3) Lange K, Carson R: EM reconstruction algorithms for emission and transmission tomography. J. Comput. Assis. Tomogr. 8: 306–316, 1984
21) Kwon SI, Gola A, Ferri A, et al.: Bismuth germanate coupled to near ultraviolet silicon photomultipliers for time-of-flight PET. Phys. Med. Bio. 61: L38, 2016
4) Gong K, Guan J, Kim K, et al.: Iterative PET image reconstruction using convolutional neural network representation. IEEE Trans. Med. Imag. 38: 675–685, 2018
22) Brunner SE, Schaart DR: BGO as a hybrid scintillator / Cherenkov radiator for cost-effective time-of-flight PET. Phys. Med. Biol. 62: 4421–4439, 2017
10) Seifert S, van Dam HT, Vinke R, et al.: A Comprehensive model to predict the timing resolution of sipm-based scintillation detectors: Theory and experimental validation. IEEE Trans Nucl. Sci. 59: 190–204, 2012
15) Korpar S, Dolenec R, Krizan P, et al.: Study of TOF PET using Cherenkov light. Nucl. Inst. Meth. A 654: 532–538, 2011
5) Haggstrom I, Schmidtlein C, Campanella G, et al.: DeepPET: A deep encoder-decoder network for directly solving the PET image reconstruction inverse problem. Med. Imag. Anal. 54: 253–262, 2019
7) Wright G: Magnetic resonance imaging. IEEE Signal Proc. Mag. 14: 56–66, 1997
8) Budinger TF: Time-of-flight positron emission tomography: Status relative to conventional PET. J. Nucl. Med. 24: 73–78, 1983
References_xml – reference: 21) Kwon SI, Gola A, Ferri A, et al.: Bismuth germanate coupled to near ultraviolet silicon photomultipliers for time-of-flight PET. Phys. Med. Bio. 61: L38, 2016
– reference: 10) Seifert S, van Dam HT, Vinke R, et al.: A Comprehensive model to predict the timing resolution of sipm-based scintillation detectors: Theory and experimental validation. IEEE Trans Nucl. Sci. 59: 190–204, 2012
– reference: 6) Hashimoto F, Onishi Y, Ote K, et al.: Deep learning-based PET image denosing and reconstruction: A review. Radiol. Phys. Technol. 17: 24–46, 2024
– reference: 20) Hendee, WR: Cross sectional medical imaging: A history. RadioGraphics 9: 1155–1180, 1989
– reference: 8) Budinger TF: Time-of-flight positron emission tomography: Status relative to conventional PET. J. Nucl. Med. 24: 73–78, 1983
– reference: 12) Gundacker S, Auffray E, Pauwels K, et al.: Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Phys. Med. Biol. 61: 2802–2837, 2016
– reference: 22) Brunner SE, Schaart DR: BGO as a hybrid scintillator / Cherenkov radiator for cost-effective time-of-flight PET. Phys. Med. Biol. 62: 4421–4439, 2017
– reference: 2) Clackdoyle R, Defrise M: Tomographic reconstruction in the 21st Century. IEEE Signal Proc. Mag. 27: 60–80, 2010
– reference: 14) Brunner SE, Gruber L, Marton J, et al.: Studies on the Cherenkov efect for improved time resolution of TOF-PET. IEEE Trans. Nucl. Sci. 61: 443–447, 2014
– reference: 5) Haggstrom I, Schmidtlein C, Campanella G, et al.: DeepPET: A deep encoder-decoder network for directly solving the PET image reconstruction inverse problem. Med. Imag. Anal. 54: 253–262, 2019
– reference: 15) Korpar S, Dolenec R, Krizan P, et al.: Study of TOF PET using Cherenkov light. Nucl. Inst. Meth. A 654: 532–538, 2011
– reference: 17) Ota R, Nakajima K, Ogawa I, et al.: Coincidence time resolution of 30 ps FWHM using a pair of Cherenkov-radiator-integrated MCP-PMTs. Phys. Med. Biol. 64: 07LT01, 2019
– reference: 1) Kwon SI, Ota R, Berg E, et al.: Ultrafast timing enables reconstruction-free positron emission imaging. Nat. Photon. 15: 914–918, 2021
– reference: 3) Lange K, Carson R: EM reconstruction algorithms for emission and transmission tomography. J. Comput. Assis. Tomogr. 8: 306–316, 1984
– reference: 7) Wright G: Magnetic resonance imaging. IEEE Signal Proc. Mag. 14: 56–66, 1997
– reference: 19) Berg E, Cherry SR: Using convolutional neural networks to estimate time-of-flight from PET detector waveforms. Phys. Med. Biol. 63: 02LT01, 2018
– reference: 4) Gong K, Guan J, Kim K, et al.: Iterative PET image reconstruction using convolutional neural network representation. IEEE Trans. Med. Imag. 38: 675–685, 2018
– reference: 11) Seifert S, van Dam HT, Schaart DR: The lower bound on the timing resolution of scintillation detectors. Phys. Med. Biol. 57: 1797–1814, 2012
– reference: 16) Ota R, Nakajima K, Hasegawa T, et al.: Timing-performance evaluation of Cherenkov-based radiation detectors. Nucl. Inst. Meth. A 923: 1–4, 2019
– reference: 9) Surti S, Karp JS: Update on latest advances in time-of-flight PET. Phys. Med. 80: 251–258, 2020
– reference: 18) Ota R, Nakajima K, Ogawa I, et al.: Lead-free MCP to improve coincidence time resolution and reduce MCP direct interactions. Phys. Med. Biol. 66: 064006, 2021
– reference: 23) Onishi Y, Hashimoto F, Ote K, et al.: Whole reconstruction-free system design for direct positron emission imaging from image generation to attenuation correction. IEEE Trans. Med. Imag. 43: 1654–1663, 2024
– reference: 13) Lecoq P, Auffray E, Brunner S, et al.: Factors influencing time resolution of scintillators and ways to improve them. IEEE Trans. Nucl. Sci. 57: 2411–2416, 2010
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SubjectTerms Cherenkov photons
direct positron emission imaging
microchannel plate photomultiplier tube
Time of Flight
Title 超高時間分解能検出器を用いた画像再構成不要陽電子放出イメージング
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