女性2型糖尿病患者の上下肢・体幹筋量とインスリン抵抗性の関連
〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した．〔対象と方法〕対象は女性2型糖尿病患者100名とした．上下肢および体幹筋量を身長の2乗または体重で除し，Homeostasis model assessment – insulin resistance（以下，HOMA-IR）との関連を検討した．〔結果〕HOMA-IRと下肢と体幹筋量の体重補正は有意な負の相関を認めた．〔結語〕女性2型糖尿病患者の下肢と体幹筋量の体重補正がインスリン抵抗性を反映する可能性が示唆された．...
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| Published in | 理学療法科学 Vol. 33; no. 3; pp. 519 - 522 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
理学療法科学学会
2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1341-1667 2434-2807 |
| DOI | 10.1589/rika.33.519 |
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| Abstract | 〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した．〔対象と方法〕対象は女性2型糖尿病患者100名とした．上下肢および体幹筋量を身長の2乗または体重で除し，Homeostasis model assessment – insulin resistance（以下，HOMA-IR）との関連を検討した．〔結果〕HOMA-IRと下肢と体幹筋量の体重補正は有意な負の相関を認めた．〔結語〕女性2型糖尿病患者の下肢と体幹筋量の体重補正がインスリン抵抗性を反映する可能性が示唆された． |
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| AbstractList | 「要旨」 : 〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した. 〔対象と方法〕対象は女性2型糖尿病患者100名とした. 上下肢および体幹筋量を身長の2乗または体重で除し, Homeostasis model assessment-insulin resistance (以下, HOMA-IR) との関連を検討した. 〔結果〕HOMA-IRと下肢と体幹筋量の体重補正は有意な負の相関を認めた. 〔結語〕女性2型糖尿病患者の下肢と体幹筋量の体重補正がインスリン抵抗性を反映する可能性が示唆された. 〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した．〔対象と方法〕対象は女性2型糖尿病患者100名とした．上下肢および体幹筋量を身長の2乗または体重で除し，Homeostasis model assessment – insulin resistance（以下，HOMA-IR）との関連を検討した．〔結果〕HOMA-IRと下肢と体幹筋量の体重補正は有意な負の相関を認めた．〔結語〕女性2型糖尿病患者の下肢と体幹筋量の体重補正がインスリン抵抗性を反映する可能性が示唆された． |
| Author | 黒瀬, 健 平沢, 良和 松木, 良介 惠飛須, 俊彦 |
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| References | 19) Berg HE, Eiken O, Miklavcic L, et al.: Hip, thigh and calf muscle atrophy and bone loss after 5-week bedrest inactivity. Eur J Appl Physiol, 2007, 99: 283-289. 15) Xu H, Barnes GT, Yang Q, et al.: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest, 2003, 112: 1821-1830. 3) Kim KS, Park KS, Kim MJ, et al.: Type 2 diabetes is associated with low muscle mass in older adults. Geriatr Gerontol Int, 2014, 14: 115-121. 17) Leon B, Jenkins S, Pepin K, et al.: Insulin and extremity muscle mass in overweight and obese women. Int J Obes, 2013, 37: 1560-1564. 5) Kim TN, Park MS, Yang SJ, et al.: Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care, 2010, 33: 1497-1499. 2) Leenders M, Verdijk LB, van der Hoeven L, et al.: Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging. J Am Med Dir Assoc, 2013, 14: 585-592. 4) Wang T, Feng X, Zhou J, et al.: Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly. Sci Rep, 2016, 6: 38937. 18) 谷本芳美，渡辺美鈴，河野 令・他：日本人筋肉量の加齢による特徴．日本老年医学会雑誌，2010, 47: 52-57. 1) 日本糖尿病学会（編）：糖尿病治療ガイド．文光堂，東京，2014，pp8-12 6) Han P, Kang L, Guo Q, et al.: Prevalence and factors associated with sarcopenia in suburb-dwelling older Chinese using the Asian working group for sarcopenia definition. J Gerontol A Biol Sci Med Sci, 2016, 71: 529-535. 7) Park SW, Goodpaster BH, Lee JS, et al. Health, Aging, and Body Composition Study: Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care, 2009, 32: 1993-1997. 8) Baumgartner RN, Koehler KM, Gallagher D, et al.: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998, 147: 755-763. 12) Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. European Working Group on Sarcopenia in Older People: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39: 412-423. 16) Sakai S, Tanimoto K, Imbe A, et al.: Decreased b-cell function is associated with reduced skeletal muscle mass in Japanese subjects without diabetes. PLoS One, 2016, 11: e0162603. 13) Tajiri Y, Kato T, Nakayama H, et al.: Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. Metab Syndr Relat Disord, 2010, 8: 137-142. 10) Srikanthan P, Karlamangla AS: Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab, 2011, 96: 2898-2903. 14) 谷山松雄，佐藤尚太郎：インスリン感受性の評価 HOMA-RとHOMA-b．日本臨床，2008, 66: 208-214. 9) Janssen I, Heymsfield SB, Ross R: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc, 2002, 50: 889-896. 11) Moon SS: Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Endocr J, 2014, 61: 61-70. |
| References_xml | – reference: 9) Janssen I, Heymsfield SB, Ross R: Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc, 2002, 50: 889-896. – reference: 6) Han P, Kang L, Guo Q, et al.: Prevalence and factors associated with sarcopenia in suburb-dwelling older Chinese using the Asian working group for sarcopenia definition. J Gerontol A Biol Sci Med Sci, 2016, 71: 529-535. – reference: 11) Moon SS: Low skeletal muscle mass is associated with insulin resistance, diabetes, and metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Endocr J, 2014, 61: 61-70. – reference: 15) Xu H, Barnes GT, Yang Q, et al.: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest, 2003, 112: 1821-1830. – reference: 17) Leon B, Jenkins S, Pepin K, et al.: Insulin and extremity muscle mass in overweight and obese women. Int J Obes, 2013, 37: 1560-1564. – reference: 10) Srikanthan P, Karlamangla AS: Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab, 2011, 96: 2898-2903. – reference: 3) Kim KS, Park KS, Kim MJ, et al.: Type 2 diabetes is associated with low muscle mass in older adults. Geriatr Gerontol Int, 2014, 14: 115-121. – reference: 5) Kim TN, Park MS, Yang SJ, et al.: Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care, 2010, 33: 1497-1499. – reference: 14) 谷山松雄，佐藤尚太郎：インスリン感受性の評価 HOMA-RとHOMA-b．日本臨床，2008, 66: 208-214. – reference: 7) Park SW, Goodpaster BH, Lee JS, et al. Health, Aging, and Body Composition Study: Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care, 2009, 32: 1993-1997. – reference: 8) Baumgartner RN, Koehler KM, Gallagher D, et al.: Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol, 1998, 147: 755-763. – reference: 4) Wang T, Feng X, Zhou J, et al.: Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly. Sci Rep, 2016, 6: 38937. – reference: 2) Leenders M, Verdijk LB, van der Hoeven L, et al.: Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging. J Am Med Dir Assoc, 2013, 14: 585-592. – reference: 1) 日本糖尿病学会（編）：糖尿病治療ガイド．文光堂，東京，2014，pp8-12． – reference: 13) Tajiri Y, Kato T, Nakayama H, et al.: Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. Metab Syndr Relat Disord, 2010, 8: 137-142. – reference: 16) Sakai S, Tanimoto K, Imbe A, et al.: Decreased b-cell function is associated with reduced skeletal muscle mass in Japanese subjects without diabetes. PLoS One, 2016, 11: e0162603. – reference: 19) Berg HE, Eiken O, Miklavcic L, et al.: Hip, thigh and calf muscle atrophy and bone loss after 5-week bedrest inactivity. Eur J Appl Physiol, 2007, 99: 283-289. – reference: 12) Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. European Working Group on Sarcopenia in Older People: Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010, 39: 412-423. – reference: 18) 谷本芳美，渡辺美鈴，河野 令・他：日本人筋肉量の加齢による特徴．日本老年医学会雑誌，2010, 47: 52-57. |
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| Snippet | 〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した．〔対象と方法〕対象は女性2型糖尿病患者100名とした．上下肢および体幹筋量を身長の2乗または体重で除し，Homeostasis model assessment – insulin... 「要旨」 : 〔目的〕女性2型糖尿病患者の上下肢および体幹筋量とインスリン抵抗性との関連を検討した. 〔対象と方法〕対象は女性2型糖尿病患者100名とした. 上下肢および体幹筋量を身長の2乗または体重で除し, Homeostasis model assessment-insulin resistance (以下,... |
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| SubjectTerms | 2型糖尿病 インスリン抵抗性 骨格筋量 |
| Title | 女性2型糖尿病患者の上下肢・体幹筋量とインスリン抵抗性の関連 |
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