EFFECT OF ANTISERUM ON THE ACTION OF SULFOBENZYLPENICILLIN

It is known that antiserum is effective for prevention of Pseudomonas infection. Studies have been done on the effect of antiserum on the antibacterial activity of SB-PC using 3 strains of Pseudomonas aeruginosa against which MIC of SB-PC was 25, 50 and over 100 mcg/ml, respectively. Mice received a...

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Published inCHEMOTHERAPY Vol. 19; no. 8; pp. 863 - 866
Main Authors ITO, MASAKO, HOMMA, YUZURU
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1971
Online AccessGet full text
ISSN0009-3165
1884-5894
DOI10.11250/chemotherapy1953.19.863

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Abstract It is known that antiserum is effective for prevention of Pseudomonas infection. Studies have been done on the effect of antiserum on the antibacterial activity of SB-PC using 3 strains of Pseudomonas aeruginosa against which MIC of SB-PC was 25, 50 and over 100 mcg/ml, respectively. Mice received antiserum subcutaneously and were challenged intraperitoneally with the live organism suspended in 5 % mucin one day or 6 hours after the administration of antiserum. Immediately after the challenge, SB-PC was given to the mice by the subcutaneous route in a single dose. A significant antiinfectious effect was evidenced by the concomitant administration of antiserum and SB-PC at such doses as do not prevent the death due to the infection in each single use. This indicates a possibility that the antibiotic might be effective in vivo against strains resistant in vitro if a trace amount of specific antibody is present in the host.
AbstractList It is known that antiserum is effective for prevention of Pseudomonas infection. Studies have been done on the effect of antiserum on the antibacterial activity of SB-PC using 3 strains of Pseudomonas aeruginosa against which MIC of SB-PC was 25, 50 and over 100 mcg/ml, respectively. Mice received antiserum subcutaneously and were challenged intraperitoneally with the live organism suspended in 5 % mucin one day or 6 hours after the administration of antiserum. Immediately after the challenge, SB-PC was given to the mice by the subcutaneous route in a single dose. A significant antiinfectious effect was evidenced by the concomitant administration of antiserum and SB-PC at such doses as do not prevent the death due to the infection in each single use. This indicates a possibility that the antibiotic might be effective in vivo against strains resistant in vitro if a trace amount of specific antibody is present in the host.
Author ITO, MASAKO
HOMMA, YUZURU
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References 2) HOSOYA, S. Y. HOMMA, F. EGAMI & Y. YAGI On the isolation of antigenic substances from Pseudomonas aeruginosa. Japan. J. Exp. Med. 20 : 55-68, 1949
3) 本間遜 : 緑膿菌々体成分と感染との諸問題. 日本臨床23 : 2408-2416, 1965
6) 山崎俊幸, 土屋院司 : 半合成ペニシリンSB-PCの実験的マウス感染症に対する治療効果について. (私信
4) MILLICAN, R. C. : Pseudomonas aeruginosa infection and its effects in non-radiation stress. Lab. Annimal Care 13 : 11-49, 1961
1) 細谷省吾, 本間遜, 林喬義 : 緑膿菌抗原の研究. 基礎と臨床 1 : 52-58, 1947
5) 本間遜 : 緑膿菌に関する最近の知見. 総合臨床19 : 2338-2347, 1970
References_xml – reference: 1) 細谷省吾, 本間遜, 林喬義 : 緑膿菌抗原の研究. 基礎と臨床 1 : 52-58, 1947
– reference: 5) 本間遜 : 緑膿菌に関する最近の知見. 総合臨床19 : 2338-2347, 1970
– reference: 6) 山崎俊幸, 土屋院司 : 半合成ペニシリンSB-PCの実験的マウス感染症に対する治療効果について. (私信)
– reference: 2) HOSOYA, S. Y. HOMMA, F. EGAMI & Y. YAGI On the isolation of antigenic substances from Pseudomonas aeruginosa. Japan. J. Exp. Med. 20 : 55-68, 1949
– reference: 4) MILLICAN, R. C. : Pseudomonas aeruginosa infection and its effects in non-radiation stress. Lab. Annimal Care 13 : 11-49, 1961
– reference: 3) 本間遜 : 緑膿菌々体成分と感染との諸問題. 日本臨床23 : 2408-2416, 1965
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Title EFFECT OF ANTISERUM ON THE ACTION OF SULFOBENZYLPENICILLIN
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