Unusual patternのlight chain deposition diseaseを呈した多発性骨髄腫の1例

症例は71歳,女性,急性腎不全にて入院.血清,尿にてκ-type Bence Jones蛋白を認め,腎組織上,大半の糸球体にWIRELOOP様に係蹄壁の著明な肥厚像をみとめた.蛍光抗体法では,糸球体係蹄壁に沿ってκchainの沈着がみられ, Light chain deposition disease (LCDD) κtypeと診断.本症例の病変はLCDDの中で非常に稀なケースであり報告した....

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Published in日本内科学会雑誌 Vol. 91; no. 2; pp. 749 - 751
Main Authors 清水, 光義, 林, 美穂, 金子, 朋広, 飯野, 靖彦, 大橋, 隆治, 岸, 雄一郎, 松信, 精一, 片山, 泰朗, 柏木, 哲也
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本内科学会 10.02.2002
Subjects
Bence Jones蛋白
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ISSN0021-5384
1883-2083
DOI10.2169/naika.91.749

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Abstract 症例は71歳,女性,急性腎不全にて入院.血清,尿にてκ-type Bence Jones蛋白を認め,腎組織上,大半の糸球体にWIRELOOP様に係蹄壁の著明な肥厚像をみとめた.蛍光抗体法では,糸球体係蹄壁に沿ってκchainの沈着がみられ, Light chain deposition disease (LCDD) κtypeと診断.本症例の病変はLCDDの中で非常に稀なケースであり報告した.
AbstractList 症例は71歳,女性,急性腎不全にて入院.血清,尿にてκ-type Bence Jones蛋白を認め,腎組織上,大半の糸球体にWIRELOOP様に係蹄壁の著明な肥厚像をみとめた.蛍光抗体法では,糸球体係蹄壁に沿ってκchainの沈着がみられ, Light chain deposition disease (LCDD) κtypeと診断.本症例の病変はLCDDの中で非常に稀なケースであり報告した.
Author 柏木, 哲也
金子, 朋広
清水, 光義
飯野, 靖彦
大橋, 隆治
林, 美穂
松信, 精一
岸, 雄一郎
片山, 泰朗
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References 2) Palant CE, et al: Nodular glomerulosclerosis associated with multiple myeloma. Am J Med 80: 98-102, 1986.
4) Preud' homme JL, et al: Synthesis of abnormal immunoglobulins in lympho-plasmacytic disorders with visceral light chain deposition. Am J Med 69: 703-710, 1980.
6) Solomon A, et al: Nephrotoxic potential of Bence Jones proteins. N Engl J Med 324: 1845, 1991.
3) Preud' homme JL, et al: Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains. Kidney Int 46: 965-972, 1994.
1) Olsen S: Mesangial thickening and no dular glomerular sclerosis in diabetes mellitus and other disease. Acta Pathol Microbiol Scand 80A suppl 233: 203-216, 1972
5) Venkataseshan VS, et al: Morphological variants of light chain deposition disease of the kidney. Am J Nephrol 8: 272-279, 1988.
References_xml – reference: 1) Olsen S: Mesangial thickening and no dular glomerular sclerosis in diabetes mellitus and other disease. Acta Pathol Microbiol Scand 80A suppl 233: 203-216, 1972
– reference: 5) Venkataseshan VS, et al: Morphological variants of light chain deposition disease of the kidney. Am J Nephrol 8: 272-279, 1988.
– reference: 3) Preud' homme JL, et al: Monoclonal immunoglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains. Kidney Int 46: 965-972, 1994.
– reference: 2) Palant CE, et al: Nodular glomerulosclerosis associated with multiple myeloma. Am J Med 80: 98-102, 1986.
– reference: 6) Solomon A, et al: Nephrotoxic potential of Bence Jones proteins. N Engl J Med 324: 1845, 1991.
– reference: 4) Preud' homme JL, et al: Synthesis of abnormal immunoglobulins in lympho-plasmacytic disorders with visceral light chain deposition. Am J Med 69: 703-710, 1980.
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Snippet 症例は71歳,女性,急性腎不全にて入院.血清,尿にてκ-type Bence Jones蛋白を認め,腎組織上,大半の糸球体にWIRELOOP様に係蹄壁の著明な肥厚像をみとめた.蛍光抗体法では,糸球体係蹄壁に沿ってκchainの沈着がみられ, Light chain deposition disease (LCDD)...
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SubjectTerms Bence Jones蛋白
Title Unusual patternのlight chain deposition diseaseを呈した多発性骨髄腫の1例
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