Rapid eye movement（REM）睡眠行動障害の診断，告知，治療
REM睡眠行動障害（rapid eye movement （REM） sleep behavior disorder; RBD）は，夢内容の行動化を呈する睡眠時随伴症である．長期的な経過観察で，αシヌクレイノパチーの発症が高率に認められる．将来の発症リスクの告知は，患者に動揺をもたらすものの，患者には知る権利があることから，適切な時期や方法を症例ごとに検討した上で告知し，告知後はRBDに対する生活指導と治療を行い，精神的にも支援する必要がある．またRBDは，他の検査との組み合わせによりαシヌクレイノパチーの早期診断を実現する可能性があり，病態抑止療法への応用が期待される．...
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| Published in | 臨床神経学 Vol. 57; no. 2; pp. 63 - 70 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本神経学会
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-918X 1882-0654 |
| DOI | 10.5692/clinicalneurol.cn-000961 |
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| Abstract | REM睡眠行動障害（rapid eye movement （REM） sleep behavior disorder; RBD）は，夢内容の行動化を呈する睡眠時随伴症である．長期的な経過観察で，αシヌクレイノパチーの発症が高率に認められる．将来の発症リスクの告知は，患者に動揺をもたらすものの，患者には知る権利があることから，適切な時期や方法を症例ごとに検討した上で告知し，告知後はRBDに対する生活指導と治療を行い，精神的にも支援する必要がある．またRBDは，他の検査との組み合わせによりαシヌクレイノパチーの早期診断を実現する可能性があり，病態抑止療法への応用が期待される． |
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| AbstractList | REM睡眠行動障害（rapid eye movement （REM） sleep behavior disorder; RBD）は，夢内容の行動化を呈する睡眠時随伴症である．長期的な経過観察で，αシヌクレイノパチーの発症が高率に認められる．将来の発症リスクの告知は，患者に動揺をもたらすものの，患者には知る権利があることから，適切な時期や方法を症例ごとに検討した上で告知し，告知後はRBDに対する生活指導と治療を行い，精神的にも支援する必要がある．またRBDは，他の検査との組み合わせによりαシヌクレイノパチーの早期診断を実現する可能性があり，病態抑止療法への応用が期待される． |
| Author | 下畑, 享良 井上, 雄一 平田, 幸一 |
| Author_xml | – sequence: 1 fullname: 平田, 幸一 organization: 獨協医科大学医学部内科学（神経） – sequence: 1 fullname: 下畑, 享良 organization: 新潟大学脳研究所神経内科 – sequence: 1 fullname: 井上, 雄一 organization: 東京医科大学/医療法人絹和会睡眠総合ケアクリニック代々木 |
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| ContentType | Journal Article |
| Copyright | 2017 日本神経学会 |
| Copyright_xml | – notice: 2017 日本神経学会 |
| DOI | 10.5692/clinicalneurol.cn-000961 |
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| References | 60) Claassen DO, Josephs KA, Ahlskog JE, et al. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 2010;75:494-499. 67) Miki Y, Tomiyama M, Ueno T, et al. Clinical availability of skin biopsy in the diagnosis of Parkinson’s disease. Neurosci Lett 2010;469:357-359. 59) Postuma RB, Gagnon JF, Vendette M, et al. Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Ann Neurol 2011;69:811-818. 10) Syed BH, Rye DB, Singh G. REM sleep behavior disorder and SCA-3 (Machado-Joseph disease). Neurology 2003;60:148. 66) Iranzo A, Lomena F, Stockner H, et al. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurol 2010;9:1070-1077. 53) Nomura T, Kawase S, Watanabe Y, et al. Use of ramelteon for the treatment of secondary REM sleep behavior disorder. Intern Med 2013;52:2123-2126. 15) Boeve BF. REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010;1184:15-54. 48) Palma JA, Fernandez-Cordon C, Coon EA, et al. Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Clin Auton Res 2015;25:69-75. 17) Lloyd R, Tippmann-Peikert M, Slocumb N, et al. Characteristics of REM sleep behavior disorder in childhood. J Clin Sleep Med 2012;8:127-131. 21) Xi Z, Luning W. REM sleep behavior disorder in a patient with pontine stroke. Sleep Med 2009;10:143-146. 42) Suzuki K, Miyamoto T, Miyamoto M, et al. Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson’s disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire. BMC Neurol 2013;13:18. 51) Iranzo A, Santamaria J, Rye DB, et al. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology 2005;65:247-252. 43) Gagnon JF, Vendette M, Postuma RB, et al. Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson’s disease. Ann Neurol 2009;66:39-47. 35) Iranzo A, Tolosa E, Gelpi E, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol 2013;12:443-453. 69) Stokholm MG, Danielsen EH, Hamilton-Dutoit SJ, et al. Pathological alpha-synuclein in gastrointestinal tissues from prodromal parkinson’s disease patients. Ann Neurol 2016;79:940-949. 14) Arnulf I, Merino-Andreu M, Bloch F, et al. REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep 2005;28:349-354. 28) Lu J, Sherman D, Devor M, et al. A putative flip-flop switch for control of REM sleep. Nature 2006;441:589-594. 64) Postuma RB, Lanfranchi PA, Blais H, at al. Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord 2010;25:2304-2310. 18) Hancock KL, St Louis EK, McCarter SJ, et al. Quantitative analyses of REM sleep without atonia in children and adolescents with REM sleep behavior disorder. Minn Med 2014;97:43. 6) Iranzo A, Santamaria J. Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder. Sleep 2005;28:203-206. 11) Iranzo A, Munoz E, Santamaria J, et al. REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. Mov Disord 2003;18:1179-1183. 61) Boeve BF. Idiopathic REM sleep behaviour disorder in the development of Parkinson’s disease. Lancet Neurol 2013;12:469-482. 45) Mahale R, Yadav R, Pal PK. Rapid eye movement sleep behaviour disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med 2014;15:642-646. 33) Postuma RB, Gagnon JF, Vendette M, et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009;72:1296-1300. 2) Miyamoto T, Miyamoto M, Iwanami M, et al. The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version. Sleep Med 2009;10:1151-1154. 44) Postuma RB, Bertrand JA, Montplaisir J, et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: a prospective study. Mov Disord 2012;27:720-726. 5) Kurahashi H, Hirose S. Autosomal dominant nocturnal frontal lobe epilepsy. In: Pagon RA, Adam MP, Ardinger HH, et al., eds. GeneReviews®. Seattle (WA): University of Washington; 1993-2017. 12) Fukutake T, Shinotoh H, Nishino H, et al. Homozygous Machado-Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms. Eur J Neurol 2002;9:97-100. 31) Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 2013;14:744-748. 40) Schenck CH, Boeve BF. The strong presence of REM sleep behavior disorder in PD: clinical and research implications. Neurology 2011;77:1030-1032. 52) McCarter SJ, Boswell CL, St Louis EK, et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med 2013;14:237-242. 65) Mahlknecht P, Iranzo A, Hogl B, et al. Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD. Neurology 2015;84:654-658. 63) King AE, Mintz J, Royall DR. Meta-analysis of 123I-MIBG cardiac scintigraphy for the diagnosis of Lewy body-related disorders. Mov Disord 2011;26:1218-1224. 37) Vertrees S, Greenough GP. Ethical considerations in REM sleep behavior disorder. Continuum (Minneap Minn) 2013;19:199-203. 29) Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007;130:2770-2788. 34) Iranzo A, Fernandez-Arcos A, Tolosa E, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One 2014;9:e89741. 39) Nihei Y, Takahashi K, Koto A, et al. REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire. J Neurol 2012;259:1606-1612. 3) Li SX, Wing YK, Lam SP, et al. Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK). Sleep Med 2010;11:43-48. 23) Schenck CH, Mahowald MW. Rapid eye movement sleep parasomnias. Neurol Clin 2005;23:1107-1126. 57) Berg D, Postuma RB, Adler CH, et al. MDS research criteria for prodromal Parkinson’s disease. Mov Disord 2015;30:1600-1611. 30) Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996;46:388-393. 68) Gibbons CH, Garcia J, Wang N, at al. The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology 2016;87:505-512. 50) 日本神経学会監修，パーキンソン病治療ガイドライン作成委員会編．パーキンソン病治療ガイドライン2011．東京：医学書院；2011. 49) Nomura T, Inoue Y, Hogl B, et al. Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson’s disease and multiple system atrophy. Psychiatry Clin Neurosci 2011;65:264-271. 55) Sasai T, Matsuura M, Inoue Y. Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. Parkinsonism Relat Disord 2013;19:153-157. 13) Friedman JH, Fernandez HH, Sudarsky LR. REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3). Mov Disord 2003;18:1520-1522. 22) Plazzi G, Montagna P. Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis. Sleep Med 2002;3:437-439. 1) Schenck CH, Bundlie SR, Ettinger MG, et al. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 1986;9:293-308. 16) Vorona RD, Ware JC. Exacerbation of REM sleep behavior disorder by chocolate ingestion: a case report. Sleep Med 2002;3:365-367. 4) Sasai T, Matsuura M, Wing YK, et al. Validation of the Japanese version of the REM sleep behavior disorder questionnaire (RBDQ-JP). Sleep Med 2012;13:913-918. 25) Adams C, McKeon A, Silber MH, et al. Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma. Arch Neurol 2011;68:521-524. 8) Suzuki K, Miyamoto T, Miyamoto M, et al. Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients. Cephalalgia 2013;33:868-878. 19) Schenck CH, Mahowald MW. Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol 1992;32:3-10. 27) Iranzo A, Aparicio J. A lesson from anatomy: focal brain lesions causing REM sleep behavior disorder. Sleep Med 2009;10:9-12. 9) Howell MJ. Parasomnias: an updated review. Neurotherapeutics 2012;9:753-775. 56) Cicolin A, Lopiano L, Zibetti M, et al. Effects of deep brain stimulation of the subthalamic nucleus on sleep architecture in parkinsonian patients. Sleep Med 2004;5:207-210. 54) Di Giacopo R, Fasano A, Quaranta D, et al. Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson’s disease. Mov Disord 2012;27:559-561. 26) Lin FC, Liu CK, Hsu CY. Rapid-eye-movement sleep behavior disorder secondary to acute aseptic limbic encephalitis. J Neurol 2009;256:1174-1176. 41) Romenets SR, Gagnon JF, Latreille V, et al. Rapid eye movement sleep behavior disorder and subtypes of Parkinson’s disease. Mov Disord 2012;27:996-1003. 62) Miyamoto T, Miyamoto M, Inoue Y, et al. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology 2006;67:2236-2238. 58) McDade EM, Boot BP, Christianson TJ, |
| References_xml | – reference: 9) Howell MJ. Parasomnias: an updated review. Neurotherapeutics 2012;9:753-775. – reference: 12) Fukutake T, Shinotoh H, Nishino H, et al. Homozygous Machado-Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms. Eur J Neurol 2002;9:97-100. – reference: 47) Murray ME, Ferman TJ, Boeve BF, et al. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. Neurology 2013;81:1681-1689. – reference: 48) Palma JA, Fernandez-Cordon C, Coon EA, et al. Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis. Clin Auton Res 2015;25:69-75. – reference: 62) Miyamoto T, Miyamoto M, Inoue Y, et al. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology 2006;67:2236-2238. – reference: 32) Iranzo A, Molinuevo JL, Santamaria J, et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol 2006;5:572-577. – reference: 67) Miki Y, Tomiyama M, Ueno T, et al. Clinical availability of skin biopsy in the diagnosis of Parkinson’s disease. Neurosci Lett 2010;469:357-359. – reference: 3) Li SX, Wing YK, Lam SP, et al. Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK). Sleep Med 2010;11:43-48. – reference: 44) Postuma RB, Bertrand JA, Montplaisir J, et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: a prospective study. Mov Disord 2012;27:720-726. – reference: 35) Iranzo A, Tolosa E, Gelpi E, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol 2013;12:443-453. – reference: 42) Suzuki K, Miyamoto T, Miyamoto M, et al. Probable rapid eye movement sleep behavior disorder, nocturnal disturbances and quality of life in patients with Parkinson’s disease: a case-controlled study using the rapid eye movement sleep behavior disorder screening questionnaire. BMC Neurol 2013;13:18. – reference: 61) Boeve BF. Idiopathic REM sleep behaviour disorder in the development of Parkinson’s disease. Lancet Neurol 2013;12:469-482. – reference: 36) Howell MJ, Schenck CH. Rapid eye movement sleep behavior disorder and neurodegenerative disease. JAMA Neurol 2015;72:707-712. – reference: 1) Schenck CH, Bundlie SR, Ettinger MG, et al. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep 1986;9:293-308. – reference: 23) Schenck CH, Mahowald MW. Rapid eye movement sleep parasomnias. Neurol Clin 2005;23:1107-1126. – reference: 21) Xi Z, Luning W. REM sleep behavior disorder in a patient with pontine stroke. Sleep Med 2009;10:143-146. – reference: 56) Cicolin A, Lopiano L, Zibetti M, et al. Effects of deep brain stimulation of the subthalamic nucleus on sleep architecture in parkinsonian patients. Sleep Med 2004;5:207-210. – reference: 64) Postuma RB, Lanfranchi PA, Blais H, at al. Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder. Mov Disord 2010;25:2304-2310. – reference: 26) Lin FC, Liu CK, Hsu CY. Rapid-eye-movement sleep behavior disorder secondary to acute aseptic limbic encephalitis. J Neurol 2009;256:1174-1176. – reference: 11) Iranzo A, Munoz E, Santamaria J, et al. REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. Mov Disord 2003;18:1179-1183. – reference: 46) Dugger BN, Boeve BF, Murray ME, et al. Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies. Mov Disord 2012;27:72-78. – reference: 8) Suzuki K, Miyamoto T, Miyamoto M, et al. Dream-enacting behaviour is associated with impaired sleep and severe headache-related disability in migraine patients. Cephalalgia 2013;33:868-878. – reference: 14) Arnulf I, Merino-Andreu M, Bloch F, et al. REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. Sleep 2005;28:349-354. – reference: 18) Hancock KL, St Louis EK, McCarter SJ, et al. Quantitative analyses of REM sleep without atonia in children and adolescents with REM sleep behavior disorder. Minn Med 2014;97:43. – reference: 58) McDade EM, Boot BP, Christianson TJ, et al. Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord 2013;28:1847-1853. – reference: 5) Kurahashi H, Hirose S. Autosomal dominant nocturnal frontal lobe epilepsy. In: Pagon RA, Adam MP, Ardinger HH, et al., eds. GeneReviews®. Seattle (WA): University of Washington; 1993-2017. – reference: 16) Vorona RD, Ware JC. Exacerbation of REM sleep behavior disorder by chocolate ingestion: a case report. Sleep Med 2002;3:365-367. – reference: 2) Miyamoto T, Miyamoto M, Iwanami M, et al. The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version. Sleep Med 2009;10:1151-1154. – reference: 69) Stokholm MG, Danielsen EH, Hamilton-Dutoit SJ, et al. Pathological alpha-synuclein in gastrointestinal tissues from prodromal parkinson’s disease patients. Ann Neurol 2016;79:940-949. – reference: 7) Suzuki K, Miyamoto M, Miyamoto T, et al. Insulinoma with early-morning abnormal behavior. Intern Med 2007;46:405-408. – reference: 22) Plazzi G, Montagna P. Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis. Sleep Med 2002;3:437-439. – reference: 19) Schenck CH, Mahowald MW. Motor dyscontrol in narcolepsy: rapid-eye-movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol 1992;32:3-10. – reference: 24) St Louis EK, McCarter SJ, Boeve BF, et al. Lesional REM sleep behavior disorder localizes to the dorsomedial pons. Neurology 2014;83:1871-1873. – reference: 57) Berg D, Postuma RB, Adler CH, et al. MDS research criteria for prodromal Parkinson’s disease. Mov Disord 2015;30:1600-1611. – reference: 20) Schenck CH, Bundlie SR, Patterson AL, et al. Rapid eye movement sleep behavior disorder. A treatable parasomnia affecting older adults. JAMA 1987;257:1786-1789. – reference: 6) Iranzo A, Santamaria J. Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder. Sleep 2005;28:203-206. – reference: 49) Nomura T, Inoue Y, Hogl B, et al. Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson’s disease and multiple system atrophy. Psychiatry Clin Neurosci 2011;65:264-271. – reference: 59) Postuma RB, Gagnon JF, Vendette M, et al. Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Ann Neurol 2011;69:811-818. – reference: 68) Gibbons CH, Garcia J, Wang N, at al. The diagnostic discrimination of cutaneous alpha-synuclein deposition in Parkinson disease. Neurology 2016;87:505-512. – reference: 27) Iranzo A, Aparicio J. A lesson from anatomy: focal brain lesions causing REM sleep behavior disorder. Sleep Med 2009;10:9-12. – reference: 30) Schenck CH, Bundlie SR, Mahowald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology 1996;46:388-393. – reference: 54) Di Giacopo R, Fasano A, Quaranta D, et al. Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson’s disease. Mov Disord 2012;27:559-561. – reference: 43) Gagnon JF, Vendette M, Postuma RB, et al. Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson’s disease. Ann Neurol 2009;66:39-47. – reference: 50) 日本神経学会監修，パーキンソン病治療ガイドライン作成委員会編．パーキンソン病治療ガイドライン2011．東京：医学書院；2011. – reference: 38) Iranzo A, Santamaria J, Tolosa E. Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions. Lancet Neurol 2016;15:405-419. – reference: 60) Claassen DO, Josephs KA, Ahlskog JE, et al. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology 2010;75:494-499. – reference: 41) Romenets SR, Gagnon JF, Latreille V, et al. Rapid eye movement sleep behavior disorder and subtypes of Parkinson’s disease. Mov Disord 2012;27:996-1003. – reference: 55) Sasai T, Matsuura M, Inoue Y. Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. Parkinsonism Relat Disord 2013;19:153-157. – reference: 39) Nihei Y, Takahashi K, Koto A, et al. REM sleep behavior disorder in Japanese patients with Parkinson’s disease: a multicenter study using the REM sleep behavior disorder screening questionnaire. J Neurol 2012;259:1606-1612. – reference: 37) Vertrees S, Greenough GP. Ethical considerations in REM sleep behavior disorder. Continuum (Minneap Minn) 2013;19:199-203. – reference: 53) Nomura T, Kawase S, Watanabe Y, et al. Use of ramelteon for the treatment of secondary REM sleep behavior disorder. Intern Med 2013;52:2123-2126. – reference: 52) McCarter SJ, Boswell CL, St Louis EK, et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med 2013;14:237-242. – reference: 65) Mahlknecht P, Iranzo A, Hogl B, et al. Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD. Neurology 2015;84:654-658. – reference: 10) Syed BH, Rye DB, Singh G. REM sleep behavior disorder and SCA-3 (Machado-Joseph disease). Neurology 2003;60:148. – reference: 66) Iranzo A, Lomena F, Stockner H, et al. Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. Lancet Neurol 2010;9:1070-1077. – reference: 4) Sasai T, Matsuura M, Wing YK, et al. Validation of the Japanese version of the REM sleep behavior disorder questionnaire (RBDQ-JP). Sleep Med 2012;13:913-918. – reference: 34) Iranzo A, Fernandez-Arcos A, Tolosa E, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One 2014;9:e89741. – reference: 70) Vilas D, Iranzo A, Tolosa E, et al. Assessment of alpha-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study. Lancet Neurol 2016;15:708-718. – reference: 45) Mahale R, Yadav R, Pal PK. Rapid eye movement sleep behaviour disorder in young- and older-onset Parkinson disease: a questionnaire-based study. Sleep Med 2014;15:642-646. – reference: 33) Postuma RB, Gagnon JF, Vendette M, et al. Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. Neurology 2009;72:1296-1300. – reference: 40) Schenck CH, Boeve BF. The strong presence of REM sleep behavior disorder in PD: clinical and research implications. Neurology 2011;77:1030-1032. – reference: 51) Iranzo A, Santamaria J, Rye DB, et al. Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. Neurology 2005;65:247-252. – reference: 17) Lloyd R, Tippmann-Peikert M, Slocumb N, et al. Characteristics of REM sleep behavior disorder in childhood. J Clin Sleep Med 2012;8:127-131. – reference: 31) Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 2013;14:744-748. – reference: 25) Adams C, McKeon A, Silber MH, et al. Narcolepsy, REM sleep behavior disorder, and supranuclear gaze palsy associated with Ma1 and Ma2 antibodies and tonsillar carcinoma. Arch Neurol 2011;68:521-524. – reference: 13) Friedman JH, Fernandez HH, Sudarsky LR. REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3). Mov Disord 2003;18:1520-1522. – reference: 28) Lu J, Sherman D, Devor M, et al. A putative flip-flop switch for control of REM sleep. Nature 2006;441:589-594. – reference: 63) King AE, Mintz J, Royall DR. Meta-analysis of 123I-MIBG cardiac scintigraphy for the diagnosis of Lewy body-related disorders. Mov Disord 2011;26:1218-1224. – reference: 15) Boeve BF. REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci 2010;1184:15-54. – reference: 29) Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007;130:2770-2788. |
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| SubjectTerms | REM睡眠行動障害 αシヌクレイノパチー 病態抑止療法 運動前症状 非運動症状 |
| Title | Rapid eye movement（REM）睡眠行動障害の診断，告知，治療 |
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