E. coli L-asparaginaseでアナフィラキシーを発現したが, Erwinia製剤で安全に寛解導入し得たALLの1例
症例は6歳の男児.急性リンパ性白血病の診断で治療を行っていたが, 31カ月後に骨髄再発を認めた.この間Eschericnia coli L-Aspを2,000単位/m2/回×42回点滴静注で使用していた.再寛解導入療法を開始後, 8回目のL-Asp静注時にアナフィラキシーが認められ, 以後L-Aspを除く他の治療を試みたが寛解導入不能であった.MTT色素還元法による薬剤感受性試験の結果, L-Aspが有効であったため, Erwinia L-Asp, Ara-C, methotrexate, vincristine, prednisoloneの併用療法を行ったところ過敏反応を認めず完全寛解が得ら...
Saved in:
| Published in | 日本小児血液学会雑誌 Vol. 8; no. 2; pp. 163 - 167 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本小児血液・がん学会
1994
|
| Online Access | Get full text |
| ISSN | 0913-8706 1884-4723 |
| DOI | 10.11412/jjph1987.8.163 |
Cover
| Abstract | 症例は6歳の男児.急性リンパ性白血病の診断で治療を行っていたが, 31カ月後に骨髄再発を認めた.この間Eschericnia coli L-Aspを2,000単位/m2/回×42回点滴静注で使用していた.再寛解導入療法を開始後, 8回目のL-Asp静注時にアナフィラキシーが認められ, 以後L-Aspを除く他の治療を試みたが寛解導入不能であった.MTT色素還元法による薬剤感受性試験の結果, L-Aspが有効であったため, Erwinia L-Asp, Ara-C, methotrexate, vincristine, prednisoloneの併用療法を行ったところ過敏反応を認めず完全寛解が得られた.この後測定した患児の抗L-Asp IgG抗体価は94U/mlと高値であった.以上より過敏反応でE. coli製剤を継続使用できない症例にも, Erwinia製剤は安全に使用でき, 有用であると思われた. |
|---|---|
| AbstractList | 症例は6歳の男児.急性リンパ性白血病の診断で治療を行っていたが, 31カ月後に骨髄再発を認めた.この間Eschericnia coli L-Aspを2,000単位/m2/回×42回点滴静注で使用していた.再寛解導入療法を開始後, 8回目のL-Asp静注時にアナフィラキシーが認められ, 以後L-Aspを除く他の治療を試みたが寛解導入不能であった.MTT色素還元法による薬剤感受性試験の結果, L-Aspが有効であったため, Erwinia L-Asp, Ara-C, methotrexate, vincristine, prednisoloneの併用療法を行ったところ過敏反応を認めず完全寛解が得られた.この後測定した患児の抗L-Asp IgG抗体価は94U/mlと高値であった.以上より過敏反応でE. coli製剤を継続使用できない症例にも, Erwinia製剤は安全に使用でき, 有用であると思われた. |
| Author | 百名, 伸之 具志堅, 俊樹 楚南, 盛章 |
| Author_xml | – sequence: 1 fullname: 具志堅, 俊樹 organization: 琉球大学医学部小児科 – sequence: 1 fullname: 楚南, 盛章 organization: 琉球大学医学部小児科 – sequence: 1 fullname: 百名, 伸之 organization: 琉球大学医学部小児科 |
| BookMark | eNo9kD9Lw0AAxQ-pYK2dXfsBTL3LXXJ3Yy31DwRcdA7X5Nom1LYkBXFwSEqHqigIIuIgWKWKWN0E0X6ZM7Qfw_p3eLzhvd8b3jxINZoNCcAignmECNKXfb9VQ5zRPMsjE8-ANGKMaITqOAXSkCOsMQrNOZANQ68MocEYhISmwX4pn3OadS9naSJsiUBUvYYIpYoGKr5WnQPVOVNxX3XuVfyo4hfVeVPx6fjidXwyUtG5iq5UdLSUKwW7XsMTk_570ruZssmwl3TvVPSQPF1OBv3k-Tjp3k77yegLKViWioboY3S4AGYroh7K7K9nwPZqaau4rlmbaxvFgqX5iGOoUewa0jAYcgkXjGBZNjlzKhRKTjClwhAO5CY2uMFdySnhWGIOSZkSveIKAnEGrPzs-mFbVKXdCrwdEezZImh7Tl3af-_ZzNa_Nf3wP3RqIrB9gT8BACOL4Q |
| ContentType | Journal Article |
| Copyright | （社）日本複写権センター |
| Copyright_xml | – notice: （社）日本複写権センター |
| DOI | 10.11412/jjph1987.8.163 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1884-4723 |
| EndPage | 167 |
| ExternalDocumentID | article_jjph1987_8_2_8_2_163_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 RJT |
| ID | FETCH-LOGICAL-j1930-73d5e5581d49a843eb698cf70e94377a5ac09635959de97493e3904b742fda403 |
| ISSN | 0913-8706 |
| IngestDate | Wed Sep 03 06:29:02 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j1930-73d5e5581d49a843eb698cf70e94377a5ac09635959de97493e3904b742fda403 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjph1987/8/2/8_2_163/_article/-char/ja |
| PageCount | 5 |
| ParticipantIDs | jstage_primary_article_jjph1987_8_2_8_2_163_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 19940000 |
| PublicationDateYYYYMMDD | 1994-01-01 |
| PublicationDate_xml | – year: 1994 text: 19940000 |
| PublicationDecade | 1990 |
| PublicationTitle | 日本小児血液学会雑誌 |
| PublicationTitleAlternate | 日小血会誌 |
| PublicationYear | 1994 |
| Publisher | 特定非営利活動法人 日本小児血液・がん学会 |
| Publisher_xml | – name: 特定非営利活動法人 日本小児血液・がん学会 |
| References | 5) Jaffe N, Traggis D, Das L, et al : L-Asparaginase in the treatment of neoplastic disease in children. Cancer 31 : 942-949, 1971 12) 月本一郎, 松井純一, 岩下弘子, 他 : 抗L-asparaginaseIgG抗体測定法の改良とその臨床的考察.臨床血液33 : 24-29, 1992 1) Ohnuma T, Holland JF, Meyer P : Erwinia carotovora asparaginase in patients with prior anaphylaxis to asparaginase from E. coli. Cancer 30 : 376-378, 1972 10) King OY, Wilbur JR, Mumfor DM, et al : Therapy with Erwinia L-asparaginase in children with acute leukemia after anaphylaxis to E. coli L-asparaginase. Cancer 33 : 611-614, 1974 3) Broome JD : Evidence that the L-asparaginase of guinea pig serum is responsible for its anti-lymphoma effects. Nature 191 : 1114-1115, 1961 9) Oettgen HF, Stephenson PA, Schwarts MK, et al : Toxicity of E. coli L-asparaginase in man. Cancer 25 : 253, 1970 2) Steinherz P, Meyers P, Wollner N, et al : Reinduction therapy for advanced or refractory acute lymphoblastic leukemia of childhood. Cancer 63 : 1472-1476, 1989 13) Billett AL,.Carls A, Gelber RD, et al : Allergic reac-tions to Erwinia asparaginase in children with acute lymphoblastic leukemia who had previous allergic reactions to Escherichia coli asparaginase. Cancer 70 : 201-206, 1992 7) Land VJ, Sutow WW, Fernbach DJ, et al : Toxicity of L-asparaginase in children with advanced leukemia. Cancer 30 : 339-347, 1972 6) Clavell LA, Gelber RD, Cohen HJ, et al : Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia. N Engl J Med 315 : 657-663, 1986 11) Hongo T, Fujii Y, Igarashi Y : An in vitro chemosen-sitivity test for the screening of anti-cancer drugs in childhood leukemia. Cancer 65 : 1263-1272, 1990 4) Whitecar JP Jr, Bodey GP, Harris JE, et al : Current concepts : L-Asparaginase. N Engl J Med 282 : 732-734, 1970 8) Ertel IJ, Nesbit ME, Hammond D, et al : Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia : a report from the Children's Cancer Study Group. Cancer Res 39 : 3893-3896, 1979 |
| References_xml | – reference: 2) Steinherz P, Meyers P, Wollner N, et al : Reinduction therapy for advanced or refractory acute lymphoblastic leukemia of childhood. Cancer 63 : 1472-1476, 1989 – reference: 5) Jaffe N, Traggis D, Das L, et al : L-Asparaginase in the treatment of neoplastic disease in children. Cancer 31 : 942-949, 1971 – reference: 3) Broome JD : Evidence that the L-asparaginase of guinea pig serum is responsible for its anti-lymphoma effects. Nature 191 : 1114-1115, 1961 – reference: 8) Ertel IJ, Nesbit ME, Hammond D, et al : Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia : a report from the Children's Cancer Study Group. Cancer Res 39 : 3893-3896, 1979 – reference: 9) Oettgen HF, Stephenson PA, Schwarts MK, et al : Toxicity of E. coli L-asparaginase in man. Cancer 25 : 253, 1970 – reference: 7) Land VJ, Sutow WW, Fernbach DJ, et al : Toxicity of L-asparaginase in children with advanced leukemia. Cancer 30 : 339-347, 1972 – reference: 12) 月本一郎, 松井純一, 岩下弘子, 他 : 抗L-asparaginaseIgG抗体測定法の改良とその臨床的考察.臨床血液33 : 24-29, 1992 – reference: 10) King OY, Wilbur JR, Mumfor DM, et al : Therapy with Erwinia L-asparaginase in children with acute leukemia after anaphylaxis to E. coli L-asparaginase. Cancer 33 : 611-614, 1974 – reference: 13) Billett AL,.Carls A, Gelber RD, et al : Allergic reac-tions to Erwinia asparaginase in children with acute lymphoblastic leukemia who had previous allergic reactions to Escherichia coli asparaginase. Cancer 70 : 201-206, 1992 – reference: 6) Clavell LA, Gelber RD, Cohen HJ, et al : Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia. N Engl J Med 315 : 657-663, 1986 – reference: 11) Hongo T, Fujii Y, Igarashi Y : An in vitro chemosen-sitivity test for the screening of anti-cancer drugs in childhood leukemia. Cancer 65 : 1263-1272, 1990 – reference: 4) Whitecar JP Jr, Bodey GP, Harris JE, et al : Current concepts : L-Asparaginase. N Engl J Med 282 : 732-734, 1970 – reference: 1) Ohnuma T, Holland JF, Meyer P : Erwinia carotovora asparaginase in patients with prior anaphylaxis to asparaginase from E. coli. Cancer 30 : 376-378, 1972 |
| SSID | ssib005880047 ssj0003236711 ssib053390765 ssib002003923 ssib058493933 |
| Score | 1.392524 |
| Snippet | 症例は6歳の男児.急性リンパ性白血病の診断で治療を行っていたが, 31カ月後に骨髄再発を認めた.この間Eschericnia coli L-Aspを2,000単位/m2/回×42回点滴静注で使用していた.再寛解導入療法を開始後, 8回目のL-Asp静注時にアナフィラキシーが認められ,... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 163 |
| Title | E. coli L-asparaginaseでアナフィラキシーを発現したが, Erwinia製剤で安全に寛解導入し得たALLの1例 |
| URI | https://www.jstage.jst.go.jp/article/jjph1987/8/2/8_2_163/_article/-char/ja |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本小児血液学会雑誌, 1994/04/30, Vol.8(2), pp.163-167 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpR1Na9RANJR68SKKit_swTnVrPmazAyeMmmWolUQWuhtSTYJdg-12BZB8LC79FAVBUFEPQhWqSJWb4Jo_0xc2p_he5NJN8UebIXs8jLz3ps3772deS87MzGMy0KwPGWxbfpCJKaX-5nJ_dw1RU5hOoEYOnNwg_PNW_7UrHd9js6Njb-urVpaWU6anQf77is5jFWhDOyKu2QPYNldplAAMNgXvsHC8P1PNo6aE2DH-YlpM17CM7zxHQtLGYlciA9JwBTgkMBRAFyBBgStqlxdEoiqZFIDkukqGeoSAXwYEYLIAAHeIjLSbQlWAS0N8LAcZe_PL8zHJOLYlATelHBBAq8mIyVBhIVYBTCvqqSqahEhFTlTwlIiLcKjCpnW2qcoTk2QYHq6YhXZJPKwmst6ME4iHwmQCwAhCcKqgZZuQFiqbRvXgwCOhMtRYk2SwFc8QyJAGwKlFLZCDqDvlRtrNrIUr6XlDCwsBPUoDi1lFx97LsWI0Ee5kDdwmERChc9UQxIBUFBgjfBLyyjNgNRAUvEPieQKEFX3U73rcfR4V9lTIEppDt0naLdkqLqOknDlKXAL_JSBuFTeBCWlW3noHbJ0NEur7TA6Ll1PjrxJ-6D7t_rrT5tt18S_1Muwo5xrOfdMj5XbzavJmNfGHKc2sdp6Gsz0Hdt_-vdsPE-42128gw_Tmry5S7fnTHX9i21XiG3edtQH0NtVJW57bHch9zriMGbjcuEbt2upOe5qr4XWFCbC2j_YkEUJi41WEECcL1yhUyuMEl08OlG9HnxXN_rkMezE1b1dgPC4C8litdBUxb4zx41jOmltBKXIJ4yxbnzSeBg1Gzj6NPaOPkVvo-i_KwaPisGLor9eDD4V_S9F_3sx-Fn0n2-_-rH9bKvovSx6b4vekysNPULsrP8arr0H2uHm2nD1Y9H7PPz6Zmdjffjt6XD1A-APt5AEftNFb9P-vfX4lDHbimbCKVO_zMXsQo5omcxNaUZhAkg9EXPPzRJf8E7OrEx4LmMxjTsWBANUUJFmgoG2MtCglzDPydPYs9zTxvjC3YXsjNGgSUpzkYsk8VIIOShkHDbNOriHP7US1z9rXCu11V4sT-xpH8Te5_6L-rxxtDxtHR_SXjDGl--tZBchbVlOLin_-QPdQwMT |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=E.+coli+L-asparaginase%E3%81%A7%E3%82%A2%E3%83%8A%E3%83%95%E3%82%A3%E3%83%A9%E3%82%AD%E3%82%B7%E3%83%BC%E3%82%92%E7%99%BA%E7%8F%BE%E3%81%97%E3%81%9F%E3%81%8C%2C+Erwinia%E8%A3%BD%E5%89%A4%E3%81%A7%E5%AE%89%E5%85%A8%E3%81%AB%E5%AF%9B%E8%A7%A3%E5%B0%8E%E5%85%A5%E3%81%97%E5%BE%97%E3%81%9FALL%E3%81%AE1%E4%BE%8B&rft.jtitle=%E6%97%A5%E6%9C%AC%E5%B0%8F%E5%85%90%E8%A1%80%E6%B6%B2%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E5%85%B7%E5%BF%97%E5%A0%85%2C+%E4%BF%8A%E6%A8%B9&rft.au=%E6%A5%9A%E5%8D%97%2C+%E7%9B%9B%E7%AB%A0&rft.au=%E7%99%BE%E5%90%8D%2C+%E4%BC%B8%E4%B9%8B&rft.date=1994&rft.pub=%E7%89%B9%E5%AE%9A%E9%9D%9E%E5%96%B6%E5%88%A9%E6%B4%BB%E5%8B%95%E6%B3%95%E4%BA%BA%E3%80%80%E6%97%A5%E6%9C%AC%E5%B0%8F%E5%85%90%E8%A1%80%E6%B6%B2%E3%83%BB%E3%81%8C%E3%82%93%E5%AD%A6%E4%BC%9A&rft.issn=0913-8706&rft.eissn=1884-4723&rft.volume=8&rft.issue=2&rft.spage=163&rft.epage=167&rft_id=info:doi/10.11412%2Fjjph1987.8.163&rft.externalDocID=article_jjph1987_8_2_8_2_163_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0913-8706&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0913-8706&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0913-8706&client=summon |