鉄による培養細胞の生育変化とこれに対する低線量放射線の作用
Fe3+-NTAを高濃度添加した肺癌由来の培養細胞の場合とは逆に, 4μg/ml以下の低濃度で添加した場合, 培養細胞の生育はよかった。さらにこの培養細胞へFe3+-NTA添加前に0.25Gyの低線量X線を照射しておくと, その良好な生育が促進するとともに, LDHの遊離も抑制した。...
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| Published in | RADIOISOTOPES Vol. 50; no. 2; pp. 37 - 42 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本アイソトープ協会
2001
|
| Online Access | Get full text |
| ISSN | 0033-8303 1884-4111 |
| DOI | 10.3769/radioisotopes.50.37 |
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| Abstract | Fe3+-NTAを高濃度添加した肺癌由来の培養細胞の場合とは逆に, 4μg/ml以下の低濃度で添加した場合, 培養細胞の生育はよかった。さらにこの培養細胞へFe3+-NTA添加前に0.25Gyの低線量X線を照射しておくと, その良好な生育が促進するとともに, LDHの遊離も抑制した。 |
|---|---|
| AbstractList | Fe3+-NTAを高濃度添加した肺癌由来の培養細胞の場合とは逆に, 4μg/ml以下の低濃度で添加した場合, 培養細胞の生育はよかった。さらにこの培養細胞へFe3+-NTA添加前に0.25Gyの低線量X線を照射しておくと, その良好な生育が促進するとともに, LDHの遊離も抑制した。 |
| Author | 小島, 周二 森, 秀治 竹原, 良記 山岡, 聖典 澁谷, 光一 |
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| References | 12) Li, J., Okada, S., Hamazaki, S., Ebina, Y. and Midorikawa, O.: Cancer Res., 4, 1867-1869 (1987 23) Jamieson, D. J., Rivers, S. L. and Stephen, D. W.: Microbiology, 140, 3277-3283 (1994 8) Covelli, V., Coppola, M., DiMajo, V., Rebessi, S. and Bassani, B.: Radiat. Res., 113, 362-369 (1988 7) Ullrich, R. L. and Storer, J. B.: Radiat. Res., 80, 135-140 (1979 24) Quintiliani, M.: Int. J. Radiat. Biol., 50, 573-594 (1986 2) Purtilo, D. T. and Gottlieb, L. S.: Cancer, 32, 458-462 (1973 13) Ebina, Y., Okada, S., Hamazaki, S., Ogaino, F., Li, J. and Midorikawa, O.: J. Natl. Cancer Inst., 76, 107-113 (1986 3) Parfrey, P. S. and Squier, M.: Br. Med. J., 1, 416 (1978 25) Ward, J. F.: Prog. Nucleic Acid Res. Mol. Biol., 35, 95-125 (1988 10) Wroblewski, F.: Proc. Soc. Exper. Biol. Med., 90, 210-213 (1955 18) Yamaoka, K., Kojima, S. and Nomura, T.: Free Radi. Res., 32, 213-221 (2000 14) Fukuda, M., Miyoshi, N., Hattori, T., Sugihara, H., Hosokawa, Y. and Nakanishi, K.: Histochemistry, 84, 556-560 (1986 4) Bates, G. W. and Sahlabach, M. R.: J. Biol. Chem., 248, 3228-3232 (1973 21) Shiraishi, N., Aono, K. and Utsumi, K.: Radiat. Res., 95, 298-302 (1983 16) Awai, M.: Protein Nucleus and Enzyme, 33, 2844-2854 (1988 22) Williams, R. S., Thomas, J. A., Fina, M., German, Z. and Benjamin, I. J.: J. Clin. Invest., 92, 503-508 (1993 11) Kiyonori, K. Biomedical Res., 16, 273-279 (1995 1) Halliday, J. W. and Powell, L. W.: Semin. Hematol., 19, 42-53 (1982 15) Fukuda, M., Hoshino, K., Naito, M. and Morita, T.: Histochemistry., 76, 1-13 (1982 6) Grahn, D., Fry, R. J. M. and Lea, R. A.: “Life Sciences and Space Research” (Vishniac, W. eds.) , vol. 10, pp. 175-181, Berlin, Academic Velag (1972 17) Yamaoka, K., Nomura, T., Iriyama, K. and Kojima, S.: Physiol. Chem. Phys. Med. NMR, 30, 15-23 (1988 19) Kimball, R. E., Reddy, K., Peirce, K., Mustafa, T. H. and Cross, C. E.: Am. J. Physiol., 230, 1425-1431 (1976 5) Kawabata, S., Awai, M. and Kohno, M.: Acta Med. Okayama, 40, 163-173 (1986 9) Okada, S., Hamazaki, S. Ebina, Y. Li, J. and Midorikawa, O.: Biochim. Biophys. Acta, 922, 28-33 (1987 20) Galiazzo, F., Schiesser, A. G. and Rotilio, G.: Biochim. Biophys. Res. Commu., 147, 1200-1205 (1987 |
| References_xml | – reference: 10) Wroblewski, F.: Proc. Soc. Exper. Biol. Med., 90, 210-213 (1955) – reference: 12) Li, J., Okada, S., Hamazaki, S., Ebina, Y. and Midorikawa, O.: Cancer Res., 4, 1867-1869 (1987) – reference: 25) Ward, J. F.: Prog. Nucleic Acid Res. Mol. Biol., 35, 95-125 (1988) – reference: 4) Bates, G. W. and Sahlabach, M. R.: J. Biol. Chem., 248, 3228-3232 (1973) – reference: 7) Ullrich, R. L. and Storer, J. B.: Radiat. Res., 80, 135-140 (1979) – reference: 21) Shiraishi, N., Aono, K. and Utsumi, K.: Radiat. Res., 95, 298-302 (1983) – reference: 18) Yamaoka, K., Kojima, S. and Nomura, T.: Free Radi. Res., 32, 213-221 (2000) – reference: 1) Halliday, J. W. and Powell, L. W.: Semin. Hematol., 19, 42-53 (1982) – reference: 8) Covelli, V., Coppola, M., DiMajo, V., Rebessi, S. and Bassani, B.: Radiat. Res., 113, 362-369 (1988) – reference: 14) Fukuda, M., Miyoshi, N., Hattori, T., Sugihara, H., Hosokawa, Y. and Nakanishi, K.: Histochemistry, 84, 556-560 (1986) – reference: 9) Okada, S., Hamazaki, S. Ebina, Y. Li, J. and Midorikawa, O.: Biochim. Biophys. Acta, 922, 28-33 (1987) – reference: 5) Kawabata, S., Awai, M. and Kohno, M.: Acta Med. Okayama, 40, 163-173 (1986) – reference: 3) Parfrey, P. S. and Squier, M.: Br. Med. J., 1, 416 (1978) – reference: 24) Quintiliani, M.: Int. J. Radiat. Biol., 50, 573-594 (1986) – reference: 13) Ebina, Y., Okada, S., Hamazaki, S., Ogaino, F., Li, J. and Midorikawa, O.: J. Natl. Cancer Inst., 76, 107-113 (1986) – reference: 22) Williams, R. S., Thomas, J. A., Fina, M., German, Z. and Benjamin, I. J.: J. Clin. Invest., 92, 503-508 (1993) – reference: 16) Awai, M.: Protein Nucleus and Enzyme, 33, 2844-2854 (1988) – reference: 2) Purtilo, D. T. and Gottlieb, L. S.: Cancer, 32, 458-462 (1973) – reference: 23) Jamieson, D. J., Rivers, S. L. and Stephen, D. W.: Microbiology, 140, 3277-3283 (1994) – reference: 17) Yamaoka, K., Nomura, T., Iriyama, K. and Kojima, S.: Physiol. Chem. Phys. Med. NMR, 30, 15-23 (1988) – reference: 6) Grahn, D., Fry, R. J. M. and Lea, R. A.: “Life Sciences and Space Research” (Vishniac, W. eds.) , vol. 10, pp. 175-181, Berlin, Academic Velag (1972) – reference: 15) Fukuda, M., Hoshino, K., Naito, M. and Morita, T.: Histochemistry., 76, 1-13 (1982) – reference: 11) Kiyonori, K. Biomedical Res., 16, 273-279 (1995) – reference: 19) Kimball, R. E., Reddy, K., Peirce, K., Mustafa, T. H. and Cross, C. E.: Am. J. Physiol., 230, 1425-1431 (1976) – reference: 20) Galiazzo, F., Schiesser, A. G. and Rotilio, G.: Biochim. Biophys. Res. Commu., 147, 1200-1205 (1987) |
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| Snippet | Fe3+-NTAを高濃度添加した肺癌由来の培養細胞の場合とは逆に, 4μg/ml以下の低濃度で添加した場合, 培養細胞の生育はよかった。さらにこの培養細胞へFe3+-NTA添加前に0.25Gyの低線量X線を照射しておくと, その良好な生育が促進するとともに, LDHの遊離も抑制した。 |
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| Title | 鉄による培養細胞の生育変化とこれに対する低線量放射線の作用 |
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