活性化protein Cはproteinase-activated receptor 1 を介して神経障害性疼痛を抑制する

• Published in: 日本薬理学会年会要旨集 p. 1-B-SS08-3
• Main Authors: 圓尾, 賢悟, 池田, 裕哉, 坪田, 真帆, 王, 登莉, 西堀, 正洋, 南, 達郎, 伊藤, 彰敏, 川畑, 篤史
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2022
• Subjects: anticoagulant; pain; peripheral nervous system

The prevention of oxaliplatin-induced peripheral neuropathy (OIPN) by thrombomodulin alfa (TMα) involves thrombin-dependent activation of protein C (PC) and thrombin-activatable fibrinolysis inhibitor (TAFI), in addition to inactivation of high mobility group box 1 (HMGB1). We have demonstrated that...