かぜ症候群後咳嗽に対する麦門冬湯と臭化水素酸デキストロメトルファンの効果の比較 (パイロット試験)
麦門冬湯 (B) は漢方薬で, 気管支炎モルモットの咳嗽を抑制することが知られている。かぜ症候群後咳嗽に麦門冬湯が有効か否か検討した。非喫煙者で, かぜ症候群後2週間以上咳嗽が続き, ACE阻害薬を内服しておらず, 鼻・副鼻腔疾患, 慢性呼吸器疾患, アトピー歴, 胃食道逆流症がなく, 胸部単純X線, 呼吸機能, 末梢血好酸球数, CRP, 血清IgE値に異常のない症例を適格症例とした。適格症例を, 無作為にBエキス顆粒9g/日と臭化水素酸デキストロメトルファン (D) 60mg/日の1週間内服群に分け, 咳日記 (咳点数0-9点に分布) を用いて, 2群間の咳嗽抑制効果を比較検討した。B13...
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| Published in | 日本東洋医学雑誌 Vol. 51; no. 4; pp. 725 - 732 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
一般社団法人 日本東洋医学会
2001
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0287-4857 1882-756X |
| DOI | 10.3937/kampomed.51.725 |
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| Abstract | 麦門冬湯 (B) は漢方薬で, 気管支炎モルモットの咳嗽を抑制することが知られている。かぜ症候群後咳嗽に麦門冬湯が有効か否か検討した。非喫煙者で, かぜ症候群後2週間以上咳嗽が続き, ACE阻害薬を内服しておらず, 鼻・副鼻腔疾患, 慢性呼吸器疾患, アトピー歴, 胃食道逆流症がなく, 胸部単純X線, 呼吸機能, 末梢血好酸球数, CRP, 血清IgE値に異常のない症例を適格症例とした。適格症例を, 無作為にBエキス顆粒9g/日と臭化水素酸デキストロメトルファン (D) 60mg/日の1週間内服群に分け, 咳日記 (咳点数0-9点に分布) を用いて, 2群間の咳嗽抑制効果を比較検討した。B13例, D12例で検討した。両群で, 年齢, 性, 来院時の咳点数, 咳嗽持続期間, 検査成績に有意差はなかった。B, D両群で有意な咳嗽抑制効果が認められたが, Bでは2日目より, Dでは3・6・7日目に, 有意に咳点数が低下した。BはDに比し, 2日目で咳嗽抑制効果が強かった (P<0.05)。両群に重篤な副作用を認めなかった。以上より, 麦門冬湯は, 非喫煙者のかぜ症候群後咳嗽に有用で, 内服後すみやかに咳嗽抑制効果を現すと考えられた。 |
|---|---|
| AbstractList | 麦門冬湯 (B) は漢方薬で, 気管支炎モルモットの咳嗽を抑制することが知られている。かぜ症候群後咳嗽に麦門冬湯が有効か否か検討した。非喫煙者で, かぜ症候群後2週間以上咳嗽が続き, ACE阻害薬を内服しておらず, 鼻・副鼻腔疾患, 慢性呼吸器疾患, アトピー歴, 胃食道逆流症がなく, 胸部単純X線, 呼吸機能, 末梢血好酸球数, CRP, 血清IgE値に異常のない症例を適格症例とした。適格症例を, 無作為にBエキス顆粒9g/日と臭化水素酸デキストロメトルファン (D) 60mg/日の1週間内服群に分け, 咳日記 (咳点数0-9点に分布) を用いて, 2群間の咳嗽抑制効果を比較検討した。B13例, D12例で検討した。両群で, 年齢, 性, 来院時の咳点数, 咳嗽持続期間, 検査成績に有意差はなかった。B, D両群で有意な咳嗽抑制効果が認められたが, Bでは2日目より, Dでは3・6・7日目に, 有意に咳点数が低下した。BはDに比し, 2日目で咳嗽抑制効果が強かった (P<0.05)。両群に重篤な副作用を認めなかった。以上より, 麦門冬湯は, 非喫煙者のかぜ症候群後咳嗽に有用で, 内服後すみやかに咳嗽抑制効果を現すと考えられた。 |
| Author | 藤森, 勝也 鈴木, 栄一 下条, 文武 |
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| References | 1) Di Pede C., et al.: Respiratory symptoms and risk factors in an Arizona population sample of Anglo and Mexican-American Whites. Chest 99, 916-922 (1991 2) Irwin R. S., et al.: Chronic cough; the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am. Rev. Respir. Dis. 141, 640-647 (1990 19) Chung K. F., et al.: Diagnosis and management of chronic persistent dry cough. Postgrad. Med. J. 72, 594-598 (1996 18) Jacoby D. B., et al.: Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J. Appl. Physiol. 64, 2653-2658 (1988 3) Poe R. H., et al.: Chronic persistent cough; experience in diagnosis and outcome using anatomic diagnostic protocol. Chest 95, 723-728 (1989 4) Fuchikami J., et al.: Comparative study of the antitussive activity of Mai-Men-Dong-Tang and codeine in normal and bronchitic guinea-pigs. Pharmacodynamics and Therapeutics (Life Sci. Adv.) 2, 37-43 (1990 15) Miyata T., et al.: Tachykinin-induced coughing and neutral endopeptidase activity in the presence of airway inflammation. Effect of Bakumondo-to and an extracted steroid saponin (ophiopogonin) from Bakumondo. Jpn. J. Inflammation 13, 435-443 (1993) (in Japanese with English abstract 8) Fujimori K., et al.: A pilot phase II study of combination therapy with oxatomide, an antihistamine, plus dextromethorphan and Bakumondo-to, an herbal drug, in patients with postinfectious persistent cough. J. Jpn. Respir. Society 36, 338-342 (1998) (in Japanese with English abstract 5) Fujimori K., et al.: A case of postinfectious chronic cough improved with Bakumondo-to not with antihistamine and dextromethorphan hydrobromide. Jpn. J. Allergol. 44, 1418-1421 (1995) (in Japanese 10) Fujimori K., et al.: Clinical features of Japanese patients with chronic cough induced by gastroesophageal reflux. Allergology International 46, 51-56 (1997 9) Poe R. H., et al.: Chronic cough: a strategy for work-up and therapy. Respiratory Diseases 18, 18-30 (1997 12) Irwin R. S., et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American college of chest physicians. Chest 114, 133S-181S (1998 16) Fuchikami J., et al.: Effect of Mai-Men-Dong-Tang, a chinese herbal medicine, and its extract on tachykinin-induced cough and neutral endopeptidase activity in the airway of bronchitic guinea-pigs. J. Med. Pharmaceut. Soc. for Wakanyaku 8, 420-421 (1991) (in Japanese 17) Miyata T.,: Current opinion of traditional medicine research. Jpn. J. Oriental Medicine 49, 177-202 (1998) (in Japanese 14) Mathys H., et al.: Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough. J. Intern. Med. Res. 11, 92-100 (1983 11) Gibson P. G., et al.: Chronic cough: eosinophilic bronchitis without asthma. Lancet 1, 1346-1348 (1989 7) Fujimori K., et al.: Effect of oxatomide, Hlantagonist, on postinfectious chronic cough; A comparison of oxatomide combined with dextromethorphan versus dextromethorphan alone. Jpn. J. Allergol. 47, 48-53 (1997) (in Japanese with English abstract 13) Aylward M., et al.: Dextromethorphan and codeine: comparison of plasma kinetics and antitussive effects. Eur. J. Respir. Dis. 65, 283-291 (1984 6) Fujimori K., et al.: Clinical features of postinfectious chronic cough. Jpn. J. Allergol. 46, 420-425 (1997) (in Japanese with English abstract 20) Braman S. S., et al.: Chronic cough. Prim. Care 12, 217-225 (1985 |
| References_xml | – reference: 11) Gibson P. G., et al.: Chronic cough: eosinophilic bronchitis without asthma. Lancet 1, 1346-1348 (1989) – reference: 7) Fujimori K., et al.: Effect of oxatomide, Hlantagonist, on postinfectious chronic cough; A comparison of oxatomide combined with dextromethorphan versus dextromethorphan alone. Jpn. J. Allergol. 47, 48-53 (1997) (in Japanese with English abstract) – reference: 2) Irwin R. S., et al.: Chronic cough; the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am. Rev. Respir. Dis. 141, 640-647 (1990) – reference: 4) Fuchikami J., et al.: Comparative study of the antitussive activity of Mai-Men-Dong-Tang and codeine in normal and bronchitic guinea-pigs. Pharmacodynamics and Therapeutics (Life Sci. Adv.) 2, 37-43 (1990) – reference: 3) Poe R. H., et al.: Chronic persistent cough; experience in diagnosis and outcome using anatomic diagnostic protocol. Chest 95, 723-728 (1989) – reference: 5) Fujimori K., et al.: A case of postinfectious chronic cough improved with Bakumondo-to not with antihistamine and dextromethorphan hydrobromide. Jpn. J. Allergol. 44, 1418-1421 (1995) (in Japanese) – reference: 15) Miyata T., et al.: Tachykinin-induced coughing and neutral endopeptidase activity in the presence of airway inflammation. Effect of Bakumondo-to and an extracted steroid saponin (ophiopogonin) from Bakumondo. Jpn. J. Inflammation 13, 435-443 (1993) (in Japanese with English abstract) – reference: 19) Chung K. F., et al.: Diagnosis and management of chronic persistent dry cough. Postgrad. Med. J. 72, 594-598 (1996) – reference: 6) Fujimori K., et al.: Clinical features of postinfectious chronic cough. Jpn. J. Allergol. 46, 420-425 (1997) (in Japanese with English abstract) – reference: 10) Fujimori K., et al.: Clinical features of Japanese patients with chronic cough induced by gastroesophageal reflux. Allergology International 46, 51-56 (1997) – reference: 8) Fujimori K., et al.: A pilot phase II study of combination therapy with oxatomide, an antihistamine, plus dextromethorphan and Bakumondo-to, an herbal drug, in patients with postinfectious persistent cough. J. Jpn. Respir. Society 36, 338-342 (1998) (in Japanese with English abstract) – reference: 14) Mathys H., et al.: Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough. J. Intern. Med. Res. 11, 92-100 (1983) – reference: 12) Irwin R. S., et al. Managing cough as a defense mechanism and as a symptom. A consensus panel report of the American college of chest physicians. Chest 114, 133S-181S (1998) – reference: 16) Fuchikami J., et al.: Effect of Mai-Men-Dong-Tang, a chinese herbal medicine, and its extract on tachykinin-induced cough and neutral endopeptidase activity in the airway of bronchitic guinea-pigs. J. Med. Pharmaceut. Soc. for Wakanyaku 8, 420-421 (1991) (in Japanese) – reference: 13) Aylward M., et al.: Dextromethorphan and codeine: comparison of plasma kinetics and antitussive effects. Eur. J. Respir. Dis. 65, 283-291 (1984) – reference: 9) Poe R. H., et al.: Chronic cough: a strategy for work-up and therapy. Respiratory Diseases 18, 18-30 (1997) – reference: 17) Miyata T.,: Current opinion of traditional medicine research. Jpn. J. Oriental Medicine 49, 177-202 (1998) (in Japanese) – reference: 1) Di Pede C., et al.: Respiratory symptoms and risk factors in an Arizona population sample of Anglo and Mexican-American Whites. Chest 99, 916-922 (1991) – reference: 18) Jacoby D. B., et al.: Influenza infection causes airway hyperresponsiveness by decreasing enkephalinase. J. Appl. Physiol. 64, 2653-2658 (1988) – reference: 20) Braman S. S., et al.: Chronic cough. Prim. Care 12, 217-225 (1985) |
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| Snippet | 麦門冬湯 (B) は漢方薬で, 気管支炎モルモットの咳嗽を抑制することが知られている。かぜ症候群後咳嗽に麦門冬湯が有効か否か検討した。非喫煙者で, かぜ症候群後2週間以上咳嗽が続き, ACE阻害薬を内服しておらず, 鼻・副鼻腔疾患, 慢性呼吸器疾患, アトピー歴, 胃食道逆流症がなく, 胸部単純X線, 呼吸機能,... |
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| SubjectTerms | かぜ症候群後咳嗽 持続性咳嗽 臭化水素酸デキストロメトルファン 麦門冬湯 |
| Title | かぜ症候群後咳嗽に対する麦門冬湯と臭化水素酸デキストロメトルファンの効果の比較 (パイロット試験) |
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