アスパラギナーゼアレルギーに伴う液性免疫の亢進と薬剤耐性の特徴

• Published in: 日本薬理学会年会要旨集 p. 1-B-P-058
• Main Authors: 原（野上）, 愛, 森, 映美加, 茶畑, 沙央里, 嶋田, 明, 見尾, 光庸
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2023
• Subjects: allergy; antiallergic agent; antibody; mast cell

L-Asparaginase (ASNase), a key drug in the treatment of childhood acute lymphoblastic leukemia, often causes allergic reactions and drug resistance. In this study, we examined the effect of cyclophosphamide (CY) on  the immune response to ASNase. Male BALB/c mice were sensitized by ASNase. CY was i....