パーキンソン病とミトコンドリア機能異常

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Published in臨床化学 Vol. 27; no. 4; pp. 202 - 209
Main Authors 服部, 信孝, 志村, 秀樹, 水野, 美邦
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本臨床化学会 31.12.1998
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ISSN0370-5633
2187-4077
DOI10.14921/jscc1971b.27.4_202

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Author 服部, 信孝
水野, 美邦
志村, 秀樹
Author_FL SHIMURA Hideki
HATTORI Nobutaka
MIZUNO Yoshikuni
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  organization: 順天堂大学医学部脳神経内科
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  fullname: 志村, 秀樹
  organization: 順天堂大学医学部脳神経内科
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  fullname: 水野, 美邦
  organization: 順天堂大学医学部脳神経内科
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References 1) Polymeropoulos MH, Higgins JJ, Golbe LI, Johnson WG, Ide SE, Di Iorio G, Stenroos FS, Pho LT, Schaffner AA, Lazzrini AM, Nussbaum RL, Duvoisin RC: Mutation in the a-synuclein g ene identified in families with Parkinson's dise ase, Science, 276: 2045-2047, 1997.
15) Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Beal MF, Yang CC, Gearing M, Salvo R: Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients, Genomics, 17: 171-184, 1993.
23) Hattori N, Yoshino H, Tanaka M, Suzuki H, Mizuno Y: Genotype in the 24-kDa subun it gene (NDUFV2) of mitochondrial com plex I and susceptibility to Parkinson disease, Genomics, 49: 52-58, 1998.
14) Ikebe S, Tanaka M, Ozawa T: Point mutations of mitochondrial genome in Parkinson's disease, Mol Brain Res, 28: 281-295, 1995.
16) Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis R E, Parker WD Jr: Origin and functional con sequences of the complex I defect in Parkin son's disease, Ann Neurol, 40: 663-671, 1 996.
25) Shimoda-Matsubayashi S, Matsumine H, Kobayshi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y: Identification of dimorphic mutatio n in the mitochondrial targeting sequenc e in the human MnSOD gene and its allelic associati on with Parkinson's disaese, Biochem B iophys Res Commun, 226: 561-565, 1995.
2) Kitada T, Shinichi A, Hattori N, Mathumine H, Yamamura Y, Minishima S, Yokochi M, Mizun o Y, Shimizu N: Deletion mutation in a novel protein “Parkin” gene cases autosomal recessive juvenile parkinsonism (AR-JP), N ature, 392: 605-608, 1998.
22) Hattori N, Suzuki H, Wang Y, Minoshima S, Shimizu N, Yoshino H, Karashima R, Ozawa T, Mizuno Y: Structural organization and chrom osomal localization of the human nuclea r ngene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial resp iratory chain, Biochem Biophys Res Com mun, 216: 771-777, 1995.
21) Shimura H, Hattori N, Kang D, Nakabeppu Y, Mizuno Y: (in submitted
13) Nakamura N, Hattori N, Tanaka M, Mizuno Y: Specific detection of deleted mitochondrial DNA by in situ, Biochim Biophys Acta, 1308: 215- 221, 1996.
9) Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC: Mitochondrial oxidative phosphorylation defects in Parkinson' disease, Ann Neurol, 30: 332-339, 1991.
8) Parker WD, Boyson SJ, Parks JK: Abnormalities of the electron transport chain in idiopathic Parkinson' disease, Ann Neurol, 26: 719-723, 1989.
12) Ikebe S, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T: Increase of d eleted mitochondrial DNA in the striatum in Parkinson's disease and senescence, Bioche m Biophys Res Commun, 163: 1450-1455, 1995.
26) Marshall KA, Daniel SE, Cairns N, Halliwell B: Upregulation of the anti-apoptotic protein Bcl-2 may be an early in neurodegeneration: studies on Parkinson's disease and incidental Lewy body disease, Biochem Biophys Res Commun, 240: 84-87, 1997.
20) Sanchez-Ramos JR, Overvik E, Ames BN: A marker of oxyradical-mediated DNA damage (8-hydroxy-2'deoxyguanosine) is increased in nigro-striatum of Parkinson' disease brain, Neurodegeneration, 3: 197-204, 1994.
24) Kobayashi T, Matsumine H, Matuda S, Mizuno Y: Association between the gene encod ing the E2 subunit of the a-ketoglutarate de hydrogenase complex and Parkinson's dis ease, Ann Neurol, 43: 120-123, 1998.
7) Schapira AV, Mann VM, Cooper JM, Clark JB, Marsden CD: Anatomic and disease specific ity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's diease, J Neuroche m, 55: 2142-2145, 1990.
4) 水野美邦服部信孝, 松峯宏人: Parkinson病と異常遺伝子, Annual Review神経, pp198-206, 中外医学社, 1998.
10) Yoshino H, Nakagawa-Hattori Y, Kondo T, Mizuno Y: Mitochondrial complex I and II acti vities of lymphocytes and platelets in Pa rkinson's disease, J Neural Transm, 41: 27-34, 1992.
19) Wood ML, Dizdaroglu M, Gajewski E: Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8- hydroxyguanine (7-hydro-8-oxoguanine) res - idue inserted at a unique site in a viral geno me, 1990 Biochemistry, 30: 7024-7032.
5) Mizuno Y, Ohta S, Tanaka M: Deficiencies in complex I subunits of the respiratory chain in Parkinson's disase, Biochem Biophys Res Com - mun, 163: 1450-1455, 1989.
6) Hattori N, Tanaka M, Ozawa T, Mizuno Y: Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's di sease, Ann Neurol, 30: 563-571, 1991.
17) Kovalenko S, Tanaka M, Hattori N: (in submitted).
11) Mizuno Y, Matsuda S, Yoshino H, Mori H, Hattori N, Ikebe S: An immunohistochem ical study on alpha-ketogluta rate dehydrogenase complex in Parkinson's disease, Ann Neurol, 35: 204-210, 1994.
3) Gasser T, Muller-Myhsok B, Wazplek ZK, Oehlmann R, Calne DB, Bonifati V, Bereznai B, Fabrizio E, Vieregge P, Horstmann R: A susce ptibility locus for Parkinson's disease maps to chromosome 2p13, Nature Genet, 18: 262-26 5, 1998.
18) Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, Othuka, Nishimura S: Misreading o f DNA templates containing. 8-hydroxydeox yguanosine at the modified base and at adjacent residues, Nature, 327: 77-79, 1987.
References_xml – reference: 15) Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Beal MF, Yang CC, Gearing M, Salvo R: Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients, Genomics, 17: 171-184, 1993.
– reference: 25) Shimoda-Matsubayashi S, Matsumine H, Kobayshi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y: Identification of dimorphic mutatio n in the mitochondrial targeting sequenc e in the human MnSOD gene and its allelic associati on with Parkinson's disaese, Biochem B iophys Res Commun, 226: 561-565, 1995.
– reference: 16) Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis R E, Parker WD Jr: Origin and functional con sequences of the complex I defect in Parkin son's disease, Ann Neurol, 40: 663-671, 1 996.
– reference: 24) Kobayashi T, Matsumine H, Matuda S, Mizuno Y: Association between the gene encod ing the E2 subunit of the a-ketoglutarate de hydrogenase complex and Parkinson's dis ease, Ann Neurol, 43: 120-123, 1998.
– reference: 9) Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC: Mitochondrial oxidative phosphorylation defects in Parkinson' disease, Ann Neurol, 30: 332-339, 1991.
– reference: 8) Parker WD, Boyson SJ, Parks JK: Abnormalities of the electron transport chain in idiopathic Parkinson' disease, Ann Neurol, 26: 719-723, 1989.
– reference: 12) Ikebe S, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T: Increase of d eleted mitochondrial DNA in the striatum in Parkinson's disease and senescence, Bioche m Biophys Res Commun, 163: 1450-1455, 1995.
– reference: 22) Hattori N, Suzuki H, Wang Y, Minoshima S, Shimizu N, Yoshino H, Karashima R, Ozawa T, Mizuno Y: Structural organization and chrom osomal localization of the human nuclea r ngene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial resp iratory chain, Biochem Biophys Res Com mun, 216: 771-777, 1995.
– reference: 23) Hattori N, Yoshino H, Tanaka M, Suzuki H, Mizuno Y: Genotype in the 24-kDa subun it gene (NDUFV2) of mitochondrial com plex I and susceptibility to Parkinson disease, Genomics, 49: 52-58, 1998.
– reference: 17) Kovalenko S, Tanaka M, Hattori N: (in submitted).
– reference: 3) Gasser T, Muller-Myhsok B, Wazplek ZK, Oehlmann R, Calne DB, Bonifati V, Bereznai B, Fabrizio E, Vieregge P, Horstmann R: A susce ptibility locus for Parkinson's disease maps to chromosome 2p13, Nature Genet, 18: 262-26 5, 1998.
– reference: 20) Sanchez-Ramos JR, Overvik E, Ames BN: A marker of oxyradical-mediated DNA damage (8-hydroxy-2'deoxyguanosine) is increased in nigro-striatum of Parkinson' disease brain, Neurodegeneration, 3: 197-204, 1994.
– reference: 11) Mizuno Y, Matsuda S, Yoshino H, Mori H, Hattori N, Ikebe S: An immunohistochem ical study on alpha-ketogluta rate dehydrogenase complex in Parkinson's disease, Ann Neurol, 35: 204-210, 1994.
– reference: 19) Wood ML, Dizdaroglu M, Gajewski E: Mechanistic studies of ionizing radiation and oxidative mutagenesis: Genetic effects of a single 8- hydroxyguanine (7-hydro-8-oxoguanine) res - idue inserted at a unique site in a viral geno me, 1990 Biochemistry, 30: 7024-7032.
– reference: 5) Mizuno Y, Ohta S, Tanaka M: Deficiencies in complex I subunits of the respiratory chain in Parkinson's disase, Biochem Biophys Res Com - mun, 163: 1450-1455, 1989.
– reference: 14) Ikebe S, Tanaka M, Ozawa T: Point mutations of mitochondrial genome in Parkinson's disease, Mol Brain Res, 28: 281-295, 1995.
– reference: 6) Hattori N, Tanaka M, Ozawa T, Mizuno Y: Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's di sease, Ann Neurol, 30: 563-571, 1991.
– reference: 2) Kitada T, Shinichi A, Hattori N, Mathumine H, Yamamura Y, Minishima S, Yokochi M, Mizun o Y, Shimizu N: Deletion mutation in a novel protein “Parkin” gene cases autosomal recessive juvenile parkinsonism (AR-JP), N ature, 392: 605-608, 1998.
– reference: 4) 水野美邦服部信孝, 松峯宏人: Parkinson病と異常遺伝子, Annual Review神経, pp198-206, 中外医学社, 1998.
– reference: 18) Kuchino Y, Mori F, Kasai H, Inoue H, Iwai S, Miura K, Othuka, Nishimura S: Misreading o f DNA templates containing. 8-hydroxydeox yguanosine at the modified base and at adjacent residues, Nature, 327: 77-79, 1987.
– reference: 1) Polymeropoulos MH, Higgins JJ, Golbe LI, Johnson WG, Ide SE, Di Iorio G, Stenroos FS, Pho LT, Schaffner AA, Lazzrini AM, Nussbaum RL, Duvoisin RC: Mutation in the a-synuclein g ene identified in families with Parkinson's dise ase, Science, 276: 2045-2047, 1997.
– reference: 21) Shimura H, Hattori N, Kang D, Nakabeppu Y, Mizuno Y: (in submitted)
– reference: 7) Schapira AV, Mann VM, Cooper JM, Clark JB, Marsden CD: Anatomic and disease specific ity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's diease, J Neuroche m, 55: 2142-2145, 1990.
– reference: 10) Yoshino H, Nakagawa-Hattori Y, Kondo T, Mizuno Y: Mitochondrial complex I and II acti vities of lymphocytes and platelets in Pa rkinson's disease, J Neural Transm, 41: 27-34, 1992.
– reference: 26) Marshall KA, Daniel SE, Cairns N, Halliwell B: Upregulation of the anti-apoptotic protein Bcl-2 may be an early in neurodegeneration: studies on Parkinson's disease and incidental Lewy body disease, Biochem Biophys Res Commun, 240: 84-87, 1997.
– reference: 13) Nakamura N, Hattori N, Tanaka M, Mizuno Y: Specific detection of deleted mitochondrial DNA by in situ, Biochim Biophys Acta, 1308: 215- 221, 1996.
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Title パーキンソン病とミトコンドリア機能異常
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