片頭痛治療の最前線

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Published in日本頭痛学会誌 Vol. 51; no. 4; pp. 680 - 682
Main Author 石井, 亮太郎
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本頭痛学会 2025
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ISSN1345-6547
2436-1577
DOI10.50860/jjho.51.4_680

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Author 石井, 亮太郎
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  organization: 京都府立医科大学大学院医学研究科脳神経内科学
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References 18) Tassorelli C, Grazzi L, de Tommaso M, et al : Noninvasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study. Neurology 91 : e364-e373, 2018.
2) Puledda F, Sacco S, Diener HC, et al : International Headache Society Global Practice Recommendations for Preventive Pharmacological Treatment of Migraine. Cephalalgia 44 : 3331024241269735, 2024.
11) Ando K, Pegram BL, Frohlich ED : Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats. Am J Physiol 258 (2 Pt 2) : R425-429, 1990.
4) Amara SG, Jonas V, Rosenfeld MG, et al : Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298 : 240-244, 1982.
6) Wimalawansa SJ, Morris HR, Etienne A, et al : Isolation, purification and characterization of beta-hCGRP from human spinal cord. Biochem Biophys Res Commun 167 : 993-1000, 1990.
13) Portaluppi F, Vergnani L, Margutti A, et al : Modulatory effect of the renin-angiotensin system on the plasma levels of calcitonin gene-related peptide in normal man. J Clin Endocrinol Metab 77 : 816-820, 1993.
9) Brain SD, Williams TJ, Tippins JR, et al : Calcitonin gene-related peptide is a potent vasodilator. Nature 313 : 54-56, 1985.
20) Tepper SJ, Grosberg B, Daniel O, et al : Migraine treatment with external concurrent occipital and trigeminal neurostimulation-A randomized controlled trial. Headache 62 : 989-1001, 2022.
3) WHO Model List of Essential Medicines-23rd list, 2023[Internet]. World Health Organization ; 2023 Jul 26[cited 2025 Feb 6]. Available from : https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2023.02
8) Lassen LH, Haderslev PA, Jacobsen VB, et al : CGRP may play a causative role in migraine. Cephalalgia 22 : 54-61, 2002.
16) Schoenen J, Vandersmissen B, Jeangette S, et al : Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial. Neurology 80 : 697-704, 2013.
5) Zaidi M, Bevis PJ, Girgis SI, et al : Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117 : 283-284, 1985.
10) Wimalawansa SJ : Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev 17 : 533-585, 1996.
19) Hershey AD, Lin T, Gruper Y, et al : Remote electrical neuromodulation for acute treatment of migraine in adolescents. Headache 61 : 310-317, 2021.
7) Mulderry PK, Ghatei MA, Bishop AE, et al : Distribution and chromatographic characterisation of CGRP-like immunoreactivity in the brain and gut of the rat. Regul Pept 12 : 133-143, 1985.
15) Ashina M, Terwindt GM, Al-Karagholi MA, et al : Migraine: disease characterisation, biomarkers, and precision medicine. Lancet 397 : 1496-1504, 2021.
1) Puledda F, Sacco S, Diener HC, et al : International Headache Society global practice recommendations for the acute pharmacological treatment of migraine. Cephalalgia 44 : 3331024241252666, 2024.
17) Starling AJ, Tepper SJ, Marmura MJ, et al : A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) . Cephalalgia 38 : 1038-1048, 2018.
12) Petersen KA, Birk S, Lassen LH, et al : The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers. Cephalalgia 25 : 139-147, 2005.
14) Li J, Wang DH : Development of angiotensin Ⅱ-induced hypertension: role of CGRP and its receptor. J Hypertens 23 : 113-118, 2005.
References_xml – reference: 3) WHO Model List of Essential Medicines-23rd list, 2023[Internet]. World Health Organization ; 2023 Jul 26[cited 2025 Feb 6]. Available from : https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2023.02
– reference: 10) Wimalawansa SJ : Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev 17 : 533-585, 1996.
– reference: 17) Starling AJ, Tepper SJ, Marmura MJ, et al : A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) . Cephalalgia 38 : 1038-1048, 2018.
– reference: 6) Wimalawansa SJ, Morris HR, Etienne A, et al : Isolation, purification and characterization of beta-hCGRP from human spinal cord. Biochem Biophys Res Commun 167 : 993-1000, 1990.
– reference: 2) Puledda F, Sacco S, Diener HC, et al : International Headache Society Global Practice Recommendations for Preventive Pharmacological Treatment of Migraine. Cephalalgia 44 : 3331024241269735, 2024.
– reference: 4) Amara SG, Jonas V, Rosenfeld MG, et al : Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298 : 240-244, 1982.
– reference: 5) Zaidi M, Bevis PJ, Girgis SI, et al : Circulating CGRP comes from the perivascular nerves. Eur J Pharmacol 117 : 283-284, 1985.
– reference: 7) Mulderry PK, Ghatei MA, Bishop AE, et al : Distribution and chromatographic characterisation of CGRP-like immunoreactivity in the brain and gut of the rat. Regul Pept 12 : 133-143, 1985.
– reference: 12) Petersen KA, Birk S, Lassen LH, et al : The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers. Cephalalgia 25 : 139-147, 2005.
– reference: 11) Ando K, Pegram BL, Frohlich ED : Hemodynamic effects of calcitonin gene-related peptide in spontaneously hypertensive rats. Am J Physiol 258 (2 Pt 2) : R425-429, 1990.
– reference: 1) Puledda F, Sacco S, Diener HC, et al : International Headache Society global practice recommendations for the acute pharmacological treatment of migraine. Cephalalgia 44 : 3331024241252666, 2024.
– reference: 9) Brain SD, Williams TJ, Tippins JR, et al : Calcitonin gene-related peptide is a potent vasodilator. Nature 313 : 54-56, 1985.
– reference: 15) Ashina M, Terwindt GM, Al-Karagholi MA, et al : Migraine: disease characterisation, biomarkers, and precision medicine. Lancet 397 : 1496-1504, 2021.
– reference: 19) Hershey AD, Lin T, Gruper Y, et al : Remote electrical neuromodulation for acute treatment of migraine in adolescents. Headache 61 : 310-317, 2021.
– reference: 20) Tepper SJ, Grosberg B, Daniel O, et al : Migraine treatment with external concurrent occipital and trigeminal neurostimulation-A randomized controlled trial. Headache 62 : 989-1001, 2022.
– reference: 16) Schoenen J, Vandersmissen B, Jeangette S, et al : Migraine prevention with a supraorbital transcutaneous stimulator: a randomized controlled trial. Neurology 80 : 697-704, 2013.
– reference: 18) Tassorelli C, Grazzi L, de Tommaso M, et al : Noninvasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study. Neurology 91 : e364-e373, 2018.
– reference: 8) Lassen LH, Haderslev PA, Jacobsen VB, et al : CGRP may play a causative role in migraine. Cephalalgia 22 : 54-61, 2002.
– reference: 13) Portaluppi F, Vergnani L, Margutti A, et al : Modulatory effect of the renin-angiotensin system on the plasma levels of calcitonin gene-related peptide in normal man. J Clin Endocrinol Metab 77 : 816-820, 1993.
– reference: 14) Li J, Wang DH : Development of angiotensin Ⅱ-induced hypertension: role of CGRP and its receptor. J Hypertens 23 : 113-118, 2005.
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SubjectTerms 抗CGRP 関連抗体
新規治療薬
片頭痛
Title 片頭痛治療の最前線
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