口腔癌の早期診断に貢献する分子生物学研究の現在（総説）
過去数十年の研究成果によって，がん患者の循環血液中にみられる腫瘍由来細胞（circulating tumor-derived cells: CTCs）あるいは末梢循環腫瘍由来核酸（circulating tumor-derived nucleic acids: ctNAs）が微小転移の兆候であり，それゆえ重要な予後因子であることが広く受け入れられてきた。これらは免疫細胞化学的あるいは分子生物学的分析法によって検出でき，さらに実際の患者においてもシステミックでリアルタイムなCTCs/ctNAsのモニタリングが可能となりつつある。本稿では，口腔がんにおける基礎から臨床応用へのCTCs/ctNAs研...
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| Published in | 日本口腔腫瘍学会誌 Vol. 25; no. 3; pp. 98 - 107 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本口腔腫瘍学会
2013
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-5988 1884-4995 |
| DOI | 10.5843/jsot.25.98 |
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| Abstract | 過去数十年の研究成果によって，がん患者の循環血液中にみられる腫瘍由来細胞（circulating tumor-derived cells: CTCs）あるいは末梢循環腫瘍由来核酸（circulating tumor-derived nucleic acids: ctNAs）が微小転移の兆候であり，それゆえ重要な予後因子であることが広く受け入れられてきた。これらは免疫細胞化学的あるいは分子生物学的分析法によって検出でき，さらに実際の患者においてもシステミックでリアルタイムなCTCs/ctNAsのモニタリングが可能となりつつある。本稿では，口腔がんにおける基礎から臨床応用へのCTCs/ctNAs研究の変遷について，われわれの最近の研究成果と併せて解説する。 |
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| AbstractList | 過去数十年の研究成果によって，がん患者の循環血液中にみられる腫瘍由来細胞（circulating tumor-derived cells: CTCs）あるいは末梢循環腫瘍由来核酸（circulating tumor-derived nucleic acids: ctNAs）が微小転移の兆候であり，それゆえ重要な予後因子であることが広く受け入れられてきた。これらは免疫細胞化学的あるいは分子生物学的分析法によって検出でき，さらに実際の患者においてもシステミックでリアルタイムなCTCs/ctNAsのモニタリングが可能となりつつある。本稿では，口腔がんにおける基礎から臨床応用へのCTCs/ctNAs研究の変遷について，われわれの最近の研究成果と併せて解説する。 |
| Author | 坂本, 洋右 馬場, 隆緒 鵜澤, 一弘 小河原, 克訓 肥後, 盛洋 丹沢, 秀樹 椎葉, 正史 笠松, 厚志 |
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| Copyright | 2013 一般社団法人 日本口腔腫瘍学会 |
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Head Neck 33: 415-423, 2011. – reference: 19) Hamana, K., Uzawa, K., et al.: Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma. Br J Cancer 92: 2181-2184, 2005. – reference: 37) Hsu, C.M., Lin, P.M., et al.: Circulating miRNA is a novel marker for head and neck squamous cell carcinoma. Tumour Biol 33: 1933-1942, 2012. – reference: 40) Uzawa, K., Baba, T., et al.: Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma. Oncotarget 3: 670-677, 2012. – reference: 11) Nunes, D.N., Kowalski, L.P., et al.: Circulating tumor-derived DNA may permit the early diagnosis of head and neck squamous cell carcinomas. Int J Cancer 92: 214-219, 2001. – reference: 52) Polyak, K., Weinberg, R.A.: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. 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| Snippet | 過去数十年の研究成果によって，がん患者の循環血液中にみられる腫瘍由来細胞（circulating tumor-derived cells: CTCs）あるいは末梢循環腫瘍由来核酸（circulating tumor-derived nucleic acids:... |
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| SubjectTerms | ミトコンドリアDNA 口腔がん予後 微小転移 末梢循環腫瘍由来核酸 末梢循環腫瘍由来細胞 |
| Title | 口腔癌の早期診断に貢献する分子生物学研究の現在（総説） |
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| ispartofPNX | 日本口腔腫瘍学会誌, 2013/09/15, Vol.25(3), pp.98-107 |
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