18F-AV45（Florbetapir F 18）を用いた認知症における脳アミロイドイメージング
要旨 【目的】18F-AV45（Florbetapir）をアルツハイマー病（AD），軽度認知機能障害（MCI），前頭側頭葉型認知症（FTLD），正常対照（HC）に対し用い比較検討し，その有用性を検討する．【方法】対象は，AD 28 例，MCI 14例，FTLD 11 例，HC 8 例．18F-AV45 を約370 MBq 静脈投与し，小脳に対する脳各部位のstandardized uptake value ratio（SUVR）を指標とした．症例群間でSUVR 値を比較した．AD とMCI におけるSUVR 値と認知機能検査との関連を検討した．【結果】SUVR 値は，AD は高値，MCI は中...
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| Published in | 脳循環代謝（日本脳循環代謝学会機関誌） Vol. 26; no. 2; pp. 11 - 18 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本脳循環代謝学会
2015
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0915-9401 2188-7519 |
| DOI | 10.16977/cbfm.26.2_11 |
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| Abstract | 要旨 【目的】18F-AV45（Florbetapir）をアルツハイマー病（AD），軽度認知機能障害（MCI），前頭側頭葉型認知症（FTLD），正常対照（HC）に対し用い比較検討し，その有用性を検討する．【方法】対象は，AD 28 例，MCI 14例，FTLD 11 例，HC 8 例．18F-AV45 を約370 MBq 静脈投与し，小脳に対する脳各部位のstandardized uptake value ratio（SUVR）を指標とした．症例群間でSUVR 値を比較した．AD とMCI におけるSUVR 値と認知機能検査との関連を検討した．【結果】SUVR 値は，AD は高値，MCI は中間値，HC とFTLD は低値であった．ADとMCI におけるSUVR 値と認知機能検査との相関はなかった．【結論】18F-AV45 アミロイドイメージングは，認知症性疾患の鑑別に有用であり，簡便で多数の組入れが可能な検査として期待される． |
|---|---|
| AbstractList | 要旨 【目的】18F-AV45（Florbetapir）をアルツハイマー病（AD），軽度認知機能障害（MCI），前頭側頭葉型認知症（FTLD），正常対照（HC）に対し用い比較検討し，その有用性を検討する．【方法】対象は，AD 28 例，MCI 14例，FTLD 11 例，HC 8 例．18F-AV45 を約370 MBq 静脈投与し，小脳に対する脳各部位のstandardized uptake value ratio（SUVR）を指標とした．症例群間でSUVR 値を比較した．AD とMCI におけるSUVR 値と認知機能検査との関連を検討した．【結果】SUVR 値は，AD は高値，MCI は中間値，HC とFTLD は低値であった．ADとMCI におけるSUVR 値と認知機能検査との相関はなかった．【結論】18F-AV45 アミロイドイメージングは，認知症性疾患の鑑別に有用であり，簡便で多数の組入れが可能な検査として期待される． |
| Author | 世良, 耕一郎 柴田, 俊秀 鈴木, 真紗子 高橋, 純子 藤澤, 豊 石塚, 直樹 米澤, 久司 小原, 智子 佐々木, 敏秋 寺崎, 一典 寺山, 靖夫 工藤, 雅子 |
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| References | 12) Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 256: 183–194, 2004 18) Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, Siuciak JA, Soares H, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative: The Alzheimer’s Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 8: S1–68, 2012 10) Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, Joshi AD, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Johnson KA, Skovronsky DM, Reiman EM: Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol 68: 1404–1411, 2011 25) Food and Drug Administration (FDA): Drug @ FDA 11) Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med 51: 913–920, 2010 14) Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51: 1546–1554, 1998 16) Joachim CL, Morris JH, Selkoe DJ: Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol 135: 309–319, 1989 22) Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC: [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67: 446–452, 2006 1) Hardy J: Alzheimer’s disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9: 151–153, 2006 21) Rabinovici GD, Furst AJ, O’Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ: 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology 68: 1205–1212, 2007 19) Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD: Developing an international network for Alzheimer research: the dominantly inherited Alzheimer network. Clin Investig 2: 975–984, 2012 24) Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, Grundman M, Mintun MA, Pontecorvo MJ, Skovronsky DM; AV45-A11 study group: Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement 9: S72–83, 2013 13) Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56: 303–308, 1999 8) Clark CM, Schneider JA, Bedell BJ et al. AV45-A07 Study Group: Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 305: 275–283, 2013 20) Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative: Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol 72: 578–586, 2012 2) Selkoe DJ: Alzheimer’s disease is a synaptic failure. Science 298: 789–791, 2004 17) Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B: Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 55: 306–319, 2004 6) Jack CR, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 131: 665–680, 2008 9) Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM: Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis Assoc Disord 26: 8–16, 2012 15) Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259, 1991 7) Koo J, Byun Y: Current status of PET-imaging probes of β-amyloid plaques. Arch Pharm Res 36: 1178–1184, 2013 23) Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative: Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 132: 1310–1323, 2009 3) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939–944, 1984 5) Klunk WE, Mathis CA: The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation. Curr Opin Neurol 21: 683–687, 2008 4) Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 270–279, 2011 |
| References_xml | – reference: 7) Koo J, Byun Y: Current status of PET-imaging probes of β-amyloid plaques. Arch Pharm Res 36: 1178–1184, 2013 – reference: 6) Jack CR, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC: 11C PiB and structural MRI provide complementary information in imaging of Alzheimer’s disease and amnestic mild cognitive impairment. Brain 131: 665–680, 2008 – reference: 16) Joachim CL, Morris JH, Selkoe DJ: Diffuse senile plaques occur commonly in the cerebellum in Alzheimer’s disease. Am J Pathol 135: 309–319, 1989 – reference: 9) Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM: Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis Assoc Disord 26: 8–16, 2012 – reference: 14) Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51: 1546–1554, 1998 – reference: 12) Petersen RC: Mild cognitive impairment as a diagnostic entity. J Intern Med 256: 183–194, 2004 – reference: 13) Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56: 303–308, 1999 – reference: 1) Hardy J: Alzheimer’s disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9: 151–153, 2006 – reference: 17) Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B: Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 55: 306–319, 2004 – reference: 8) Clark CM, Schneider JA, Bedell BJ et al. AV45-A07 Study Group: Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 305: 275–283, 2013 – reference: 24) Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, Grundman M, Mintun MA, Pontecorvo MJ, Skovronsky DM; AV45-A11 study group: Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement 9: S72–83, 2013 – reference: 2) Selkoe DJ: Alzheimer’s disease is a synaptic failure. Science 298: 789–791, 2004 – reference: 20) Landau SM, Mintun MA, Joshi AD, Koeppe RA, Petersen RC, Aisen PS, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative: Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Ann Neurol 72: 578–586, 2012 – reference: 5) Klunk WE, Mathis CA: The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation. Curr Opin Neurol 21: 683–687, 2008 – reference: 18) Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, Morris JC, Petersen RC, Saykin AJ, Schmidt ME, Shaw L, Siuciak JA, Soares H, Toga AW, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative: The Alzheimer’s Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement 8: S1–68, 2012 – reference: 10) Fleisher AS, Chen K, Liu X, Roontiva A, Thiyyagura P, Ayutyanont N, Joshi AD, Clark CM, Mintun MA, Pontecorvo MJ, Doraiswamy PM, Johnson KA, Skovronsky DM, Reiman EM: Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease. Arch Neurol 68: 1404–1411, 2011 – reference: 25) Food and Drug Administration (FDA): Drug @ FDA – reference: 19) Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, Oliver A, Quaid K, Ringman JM, Rossor MN, Salloway S, Schofield PR, Selsor NJ, Sperling RA, Weiner MW, Xiong C, Moulder KL, Buckles VD: Developing an international network for Alzheimer research: the dominantly inherited Alzheimer network. Clin Investig 2: 975–984, 2012 – reference: 21) Rabinovici GD, Furst AJ, O’Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ: 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology 68: 1205–1212, 2007 – reference: 11) Wong DF, Rosenberg PB, Zhou Y, Kumar A, Raymont V, Ravert HT, Dannals RF, Nandi A, Brasić JR, Ye W, Hilton J, Lyketsos C, Kung HF, Joshi AD, Skovronsky DM, Pontecorvo MJ: In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med 51: 913–920, 2010 – reference: 22) Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC: [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 67: 446–452, 2006 – reference: 3) McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34: 939–944, 1984 – reference: 23) Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ; Alzheimer’s Disease Neuroimaging Initiative: Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain 132: 1310–1323, 2009 – reference: 4) Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7: 270–279, 2011 – reference: 15) Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239–259, 1991 |
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| Snippet | 要旨 【目的】18F-AV45（Florbetapir）をアルツハイマー病（AD），軽度認知機能障害（MCI），前頭側頭葉型認知症（FTLD），正常対照（HC）に対し用い比較検討し，その有用性を検討する．【方法】対象は，AD 28 例，MCI 14例，FTLD 11 例，HC 8 例．18F-AV45 を約370... |
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| SubjectTerms | 18F-AV45 PET 脳アミロイドイメージング 認知症 |
| Title | 18F-AV45（Florbetapir F 18）を用いた認知症における脳アミロイドイメージング |
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| ispartofPNX | 脳循環代謝（日本脳循環代謝学会機関誌）, 2015, Vol.26(2), pp.11-18 |
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