Clinical study of ritipenem acoxil for surgical field infections
We administered ritipenem acoxil, an oral penem antibiotic, to 18 patients with surgical field infection (7 with infectious atheroma, 3 with periproctal abscess, 5 with abscess, 2 with wound infection, and 1 with mastitis). Evaluation was possible in 15 patients. The clinical efficacy was excellent...
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| Published in | Japanese Journal of Chemotherapy Vol. 43; no. Supplement3; pp. 561 - 563 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Chemotherapy
1995
公益社団法人 日本化学療法学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1340-7007 1884-5886 |
| DOI | 10.11250/chemotherapy1995.43.Supplement3_561 |
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| Abstract | We administered ritipenem acoxil, an oral penem antibiotic, to 18 patients with surgical field infection (7 with infectious atheroma, 3 with periproctal abscess, 5 with abscess, 2 with wound infection, and 1 with mastitis). Evaluation was possible in 15 patients. The clinical efficacy was excellent in 6 patients and good in 9; the efficacy rate was 100%. Bacteriologically, 20 bacterial strains were isolated from 12 patients. The strain was eradicated in 11 patients but unchanged in 1. None of the patients showed side effects or abnormal laboratory findings associated with administration of this drug. |
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| AbstractList | We administered ritipenem acoxil, an oral penem antibiotic, to 18 patients with surgical field infection (7 with infectious atheroma, 3 with periproctal abscess, 5 with abscess, 2 with wound infection, and 1 with mastitis). Evaluation was possible in 15 patients. The clinical efficacy was excellent in 6 patients and good in 9; the efficacy rate was 100%. Bacteriologically, 20 bacterial strains were isolated from 12 patients. The strain was eradicated in 11 patients but unchanged in 1. None of the patients showed side effects or abnormal laboratory findings associated with administration of this drug. We administered ritipenem acoxil, an oral penem antibiotic, to 18 patients with surgical field infection (7 with infectious atheroma, 3 with periproctal abscess, 5 with abscess, 2 with wound infection, and 1 with mastitis). Evaluation was possible in 15 patients. The clinical efficacy was excellent in 6 patients and good in 9; the efficacy rate was 100%. Bacteriologically, 20 bacterial strains were isolated from 12 patients. The strain was eradicated in 11 patients but unchanged in 1. None of the patients showed side effects or abnormal laboratory findings associated with administration of this drug. 新しく開発された, 経口ペネム系抗生物質ritipenem acoxilを外科領域感染症 (感染性粉瘤7例, 肛門周囲膿瘍3例, 皮下膿瘍5例, 創感染2例, 乳腺炎1例) の計18例に使用し, 以下の結果を得た。評価可能であった15例での臨床効果は著効6例, 有効9例で, 有効率100%であった。細菌学的効果は, 12例より20株の菌が検出され, 消失11例, 存続1例であった。一方, 本剤投与によると思われる副作用および臨床検査値の異常変動は1例も認められなかった。 |
| Author | Nohga, Katsuhiko |
| Author_FL | 納賀 克彦 |
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| Author_xml | – sequence: 1 fullname: Nohga, Katsuhiko organization: Department of Surgery, Kawasaki City Hospital |
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| References | 1) 熊澤淨一: 第42回日本化学療法学会総会, 新薬シンポジウム. FC/TA-891, 福岡, 1994 |
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| Title | Clinical study of ritipenem acoxil for surgical field infections |
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