Penetration of cefluprenam into wound exudate and bile, and clinical studies of cefluprenam for surgical application

• Published in: Japanese Journal of Chemotherapy Vol. 43; no. Supplement4; pp. 166 - 169
• Main Authors: Yokoyama, Isao, Nohga, Katsuhiko
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1995; 公益社団法人 日本化学療法学会
• Subjects: cefluprenam; 創液中移行; 外科感染症; 胆汁中移行; 臨床的検討
• ISSN: 1340-7007; 1884-5886
• DOI: 10.11250/chemotherapy1995.43.Supplement4_166

We investigated the clinical efficacy of cefluprenam (CFLP), a newly developed injectable antibiotic, against various surgical infections.We also studied the drug distribution into wound exudate and bile. The CFLP concentrations in exudate were 13.4±3.2 μg/ml after 1 hour and 6.26μg/ml after 6 hours.The concentration of CFLP in bile was 23.8μg/ml after 1 hour with 30 min drip infusion of 1 g of CFLP. The clinical efficacy of CFLP was evaluated in 10 cases.There was seen good in all cases.The bacteriological response was investigated in 14 strains Gram-positive bacteria (6 strains), Gram-negative bacteria (5 strains), and anaerobes (3 strains) exhibiting 92.9 % of the eradication rate.Although no adverse drug reaction was recognaized, mild abnormal laboratory findings were noted in 1 case.