第30回 日本肝臓学会総会記録(1) シンポジウム(1)肝再生機序-臨床との接点において

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Published in肝臓 Vol. 36; no. 2; pp. 117 - 137
Main Authors 水戸, 廸郎, 沖田, 極, 永末, 直文
Format Journal Article
LanguageJapanese
Published 一般社団法人 日本肝臓学会 1995
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ISSN0451-4203
1881-3593
DOI10.2957/kanzo.36.117

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Author 沖田, 極
永末, 直文
水戸, 廸郎
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  organization: 旭川市民文化会館大ホール
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  fullname: 沖田, 極
  organization: 山口大学第1内科
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  fullname: 永末, 直文
  organization: 島根医科大学第2外科
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References 1) Saint-Aubert B, Astre C, Andriguetta P, et al: Influence of nutrition on liver regeneration. In New Aspects of Clinical Nutrition, Kleinberg G, Deutsh E (eds). Karger, Basel, 1983, p 548-557
1) Ohnishi H, Muto Y, Maeda T, et al: Natural killer cell may impair liver regeneration in fulminant hepatic failure. Gastroenterol Jpn 28 (Suppl 4): 40-44, 1993
2) Kawasaki S, Makuuchi M, Ishizone S, et al: Liver regeneration in recipients and donors after transplantation. Lancet 339: 580-581, 1992
5) Iiai T, Watanabe H, Seki S, et al: Ontogeny and development of extrathymic T cell in mouse liver. Immunol 77: 556-563, 1992
2) Shiota G, Wang T, Nakamura T, et al: Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expressin. Hepatology 19: 962-972, 1994
1) Tomiya T, Tani M, Yamada S, et al: Gastroenterology 103: 1621-1624, 1992
3) Kayano K, Yasunaga M, Okita K, et al: Liver 12: 132-136, 1992
4) Nakamura T, Teramoto H, Ichihara A, et al: Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224: 311-316, 1987
4) Shiota G, Nakamura T, Schmidt EV: Hepatocyte growth factor regulates transforming growth factor α in HepG2 hepatic cells. Biochem Biophys Res Commun 200: 1099-1104, 1994
3) 東口高志,横井一,野口孝,他:肝不全.救急医学 17: 1567-1571, 1993
3) Webber EM, Fitzgerald MJ, Brown PI, et al: Transforming growth factor α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor α and hepatocyte growth factor. Hepatology 18: 1422-1431, 1993
3) Francavilla A, Panella C, Polimeno L, et al: Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major hepatic resection. Hepatology 12: 1134-1138, 1990
2) Tomiya T, Tani M, Yamada S, et al: Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients. Gastroenterlology 103: 1621-1624, 1992
1) Okamoto E, Yamanaka N: A morphometric study on regeneration of human liver following hepatectomy by computed tomography (in Japanese). Kanzou 24: 870-877, 1983
5) Higashiguchi T, Hasselgren PO, Wagner K, et al: Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. JPEN 17: 307-314, 1993
2) Seki S, Abo T, Ohteki T, et al: Unusual α β-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J Immunol 147: 1214-1221, 1991
4) Tarao K, et al: Increased DNA synthetic potency of hepatocytes in cirrhotic patients may indicate a super-high-risk for hepatocellular carcinoma. Jpn J Med 29 (4): 373-378, 1990
2) Yamanaka N, Okamoto E, Kawamura E, et al: Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the Basis of computed tomography and liver function. Hepatology 18 (1): 79-85, 1993
3) Abo T, Kusumi A, Seki S, et al: Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell Immunol 142: 125-136, 1992
5) Lindroos P, Zarnegar R, Michalopoulos GK: Hepatocyte growth factor (hepatopoietin A) eapidly increase in plasmabefore DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachrolide administration. Hepatology 13: 743-750, 1991
4) Franacavilla A, Starzl TE, Barone M, et al: Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506. Hepatology 14: 140-143, 1991
1) Tarao K, et al: Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology 103: 595-600, 1992
4) 加藤年啓,山中若樹,岡本英三:多変量解析による慢性肝疾患重症度の術前予測.肝臓 34 (10): 791-797, 1993
3) Kahan D, Lai HS, Romovacek H, et al: Cyclosporine A augments the regenerative response after partial hepatectomy in the rat. Transplant Proc 20: 850-852, 1988
1) Shiota G, Rhoads D, Wang T, et al: Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 89: 373-377, 1992
3) Tomiya T, Fujiwara K: Serum levels of transforming growth factor α in patients after partial hepatectomy as determined with an enzyme linked immunosorbent assay. Hepatology 18: 304-308, 1993
3) Tarao K, et al: Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C viruspositive cirrhotic patients. Cancer 73: 1149-1154, 1994
1) Lin T-Y, Lee C-s, Chen C-C, et al: Regeneration of human liver after hepatic lobectomy by repeated liver scanning and repeated needle biopsy. Ann Surg 190: 48-53, 1970
1) Kawasaki S, Makuuchi M, Matsunami H, et al: Preoperative measurement of segmental liver volume of donors for living related liver transplantation. Hepatology 18: 1115-1120, 1993
2) Masuhara M, Katyal SL, Shinozuka H, et al: Hepatology 16: 1241-1249, 1992
4) Abo T, Ohteki T, Seki S, et al: The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J Exp Med 174: 417-424, 1991
5) Henderson JM, Millikan WJ, Hooks M, et al: Increased galactose clearance after liver transplantation: A measure of increased blood flow through the denervated liver? Hepatology 10: 288-291, 1988
2) Tarao K, et al: The male preponderance in incidence of hepatocellular carcinoma in cirrhotic patients may depend on the higher DNA synthetic activity of cirrhotic tissue in men. Cancer 72: 369-374, 1993
2) 野口孝,伊藤彰博,東口高志,他:肝切除後の肝再生-臨床例の検討,肝再生能の予測と対策-.肝胆膵 28: 873-882, 1994
4) McNurlan MA, Tomkins AM, Garlick PJ: The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J 178: 373-379, 1979
1) Tomiya T, Nagoshi S, Fujiwara K: Significance of serum Human Hepatocyte Growth Factor Levels in Patients with Hepatic Failure. Hepatology 15: 1-4, 1992
2) Nagasue N, Yukaya H, Ogawa Y, et al: Human liver regeneration after major hepatic resection-A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 206: 30-39, 1987
4) Ramadori G, Neubauer K, Odenthal M, et al: Biochem Biophys Res Commun 183: 734-742, 1992
3) 山中若樹,岡本英三,豊坂昭弘,他:ヒト肝切除後の脾動態に関する研究.肝臓 30 (1): 49-54, 1989
References_xml – reference: 2) Tomiya T, Tani M, Yamada S, et al: Serum hepatocyte growth factor levels in hepatectomized and nonhepatectomized surgical patients. Gastroenterlology 103: 1621-1624, 1992
– reference: 3) Tomiya T, Fujiwara K: Serum levels of transforming growth factor α in patients after partial hepatectomy as determined with an enzyme linked immunosorbent assay. Hepatology 18: 304-308, 1993
– reference: 4) McNurlan MA, Tomkins AM, Garlick PJ: The effect of starvation on the rate of protein synthesis in rat liver and small intestine. Biochem J 178: 373-379, 1979
– reference: 2) Shiota G, Wang T, Nakamura T, et al: Hepatocyte growth factor in transgenic mice: Effects on hepatocyte growth, liver regeneration and gene expressin. Hepatology 19: 962-972, 1994
– reference: 1) Lin T-Y, Lee C-s, Chen C-C, et al: Regeneration of human liver after hepatic lobectomy by repeated liver scanning and repeated needle biopsy. Ann Surg 190: 48-53, 1970
– reference: 4) Ramadori G, Neubauer K, Odenthal M, et al: Biochem Biophys Res Commun 183: 734-742, 1992
– reference: 2) Nagasue N, Yukaya H, Ogawa Y, et al: Human liver regeneration after major hepatic resection-A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 206: 30-39, 1987
– reference: 3) Abo T, Kusumi A, Seki S, et al: Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell Immunol 142: 125-136, 1992
– reference: 5) Higashiguchi T, Hasselgren PO, Wagner K, et al: Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. JPEN 17: 307-314, 1993
– reference: 4) Nakamura T, Teramoto H, Ichihara A, et al: Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett 224: 311-316, 1987
– reference: 1) Tomiya T, Nagoshi S, Fujiwara K: Significance of serum Human Hepatocyte Growth Factor Levels in Patients with Hepatic Failure. Hepatology 15: 1-4, 1992
– reference: 3) Kahan D, Lai HS, Romovacek H, et al: Cyclosporine A augments the regenerative response after partial hepatectomy in the rat. Transplant Proc 20: 850-852, 1988
– reference: 4) Shiota G, Nakamura T, Schmidt EV: Hepatocyte growth factor regulates transforming growth factor α in HepG2 hepatic cells. Biochem Biophys Res Commun 200: 1099-1104, 1994
– reference: 1) Kawasaki S, Makuuchi M, Matsunami H, et al: Preoperative measurement of segmental liver volume of donors for living related liver transplantation. Hepatology 18: 1115-1120, 1993
– reference: 5) Henderson JM, Millikan WJ, Hooks M, et al: Increased galactose clearance after liver transplantation: A measure of increased blood flow through the denervated liver? Hepatology 10: 288-291, 1988
– reference: 3) Webber EM, Fitzgerald MJ, Brown PI, et al: Transforming growth factor α expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor α and hepatocyte growth factor. Hepatology 18: 1422-1431, 1993
– reference: 5) Iiai T, Watanabe H, Seki S, et al: Ontogeny and development of extrathymic T cell in mouse liver. Immunol 77: 556-563, 1992
– reference: 1) Tarao K, et al: Development of hepatocellular carcinoma associated with increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology 103: 595-600, 1992
– reference: 3) Francavilla A, Panella C, Polimeno L, et al: Hormonal and enzymatic parameters of hepatic regeneration in patients undergoing major hepatic resection. Hepatology 12: 1134-1138, 1990
– reference: 2) Seki S, Abo T, Ohteki T, et al: Unusual α β-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J Immunol 147: 1214-1221, 1991
– reference: 2) Yamanaka N, Okamoto E, Kawamura E, et al: Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the Basis of computed tomography and liver function. Hepatology 18 (1): 79-85, 1993
– reference: 1) Okamoto E, Yamanaka N: A morphometric study on regeneration of human liver following hepatectomy by computed tomography (in Japanese). Kanzou 24: 870-877, 1983
– reference: 1) Tomiya T, Tani M, Yamada S, et al: Gastroenterology 103: 1621-1624, 1992
– reference: 2) Tarao K, et al: The male preponderance in incidence of hepatocellular carcinoma in cirrhotic patients may depend on the higher DNA synthetic activity of cirrhotic tissue in men. Cancer 72: 369-374, 1993
– reference: 1) Ohnishi H, Muto Y, Maeda T, et al: Natural killer cell may impair liver regeneration in fulminant hepatic failure. Gastroenterol Jpn 28 (Suppl 4): 40-44, 1993
– reference: 5) Lindroos P, Zarnegar R, Michalopoulos GK: Hepatocyte growth factor (hepatopoietin A) eapidly increase in plasmabefore DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachrolide administration. Hepatology 13: 743-750, 1991
– reference: 3) Tarao K, et al: Significance of hepatocellular proliferation in the development of hepatocellular carcinoma from anti-hepatitis C viruspositive cirrhotic patients. Cancer 73: 1149-1154, 1994
– reference: 2) 野口孝,伊藤彰博,東口高志,他:肝切除後の肝再生-臨床例の検討,肝再生能の予測と対策-.肝胆膵 28: 873-882, 1994
– reference: 1) Saint-Aubert B, Astre C, Andriguetta P, et al: Influence of nutrition on liver regeneration. In New Aspects of Clinical Nutrition, Kleinberg G, Deutsh E (eds). Karger, Basel, 1983, p 548-557
– reference: 3) 東口高志,横井一,野口孝,他:肝不全.救急医学 17: 1567-1571, 1993
– reference: 3) Kayano K, Yasunaga M, Okita K, et al: Liver 12: 132-136, 1992
– reference: 3) 山中若樹,岡本英三,豊坂昭弘,他:ヒト肝切除後の脾動態に関する研究.肝臓 30 (1): 49-54, 1989
– reference: 4) 加藤年啓,山中若樹,岡本英三:多変量解析による慢性肝疾患重症度の術前予測.肝臓 34 (10): 791-797, 1993
– reference: 4) Franacavilla A, Starzl TE, Barone M, et al: Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506. Hepatology 14: 140-143, 1991
– reference: 2) Masuhara M, Katyal SL, Shinozuka H, et al: Hepatology 16: 1241-1249, 1992
– reference: 2) Kawasaki S, Makuuchi M, Ishizone S, et al: Liver regeneration in recipients and donors after transplantation. Lancet 339: 580-581, 1992
– reference: 1) Shiota G, Rhoads D, Wang T, et al: Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 89: 373-377, 1992
– reference: 4) Abo T, Ohteki T, Seki S, et al: The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J Exp Med 174: 417-424, 1991
– reference: 4) Tarao K, et al: Increased DNA synthetic potency of hepatocytes in cirrhotic patients may indicate a super-high-risk for hepatocellular carcinoma. Jpn J Med 29 (4): 373-378, 1990
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SubjectTerms NK細胞
劇症肝炎
性差
経腸栄養
肝再生
肝再生不全
肝再生予知
肝切除
肝移植
肝細胞再生
肝細胞増殖
胸腺外分化T細胞
高濃度分岐鎖アミノ酸
Subtitle シンポジウム(1)肝再生機序-臨床との接点において
Title 第30回 日本肝臓学会総会記録(1)
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Volume 36
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