小腸の阻血と血流再開後の粘膜障害に関する実験的研究
xanthme oxidaseを阻害しfree radicalsの産生を抑制するallopurinolの投与と灌流の, 小腸の阻血と血流再開後の粘膜障害に対する保護効果を, 主に, イヌの小腸絨毛のNa+-K+ATPase活性の変化から検討し, 次の結論を得た.灌流またはsuperoxide産生阻害剤を投与しなかった群と灌流またはsuperoxide産生阻害剤の投与の単独実施群では, control群より有意 (p<0.05) にNa+-K+ATPase活性は低下した.superoxide産生阻害剤を投与し, 同時に灌流を実施した群ではその低下が有意 (p<0.05) に抑制された...
Saved in:
| Published in | 日本消化器外科学会雑誌 Vol. 23; no. 9; pp. 2244 - 2250 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本消化器外科学会
1990
|
| Online Access | Get full text |
| ISSN | 0386-9768 1348-9372 |
| DOI | 10.5833/jjgs.23.2244 |
Cover
| Abstract | xanthme oxidaseを阻害しfree radicalsの産生を抑制するallopurinolの投与と灌流の, 小腸の阻血と血流再開後の粘膜障害に対する保護効果を, 主に, イヌの小腸絨毛のNa+-K+ATPase活性の変化から検討し, 次の結論を得た.灌流またはsuperoxide産生阻害剤を投与しなかった群と灌流またはsuperoxide産生阻害剤の投与の単独実施群では, control群より有意 (p<0.05) にNa+-K+ATPase活性は低下した.superoxide産生阻害剤を投与し, 同時に灌流を実施した群ではその低下が有意 (p<0.05) に抑制された.したがって, 小腸の阻血と血流再開後の粘膜障害としてNa+-K+ATPase活性が低下すること, また, その原因としてfreeradicalsが関与し, さらに, superoxide産生阻害剤としてのallopurinolの投与は阻血と血流再開後の小腸粘膜の保護に有効であることを明らかにした. |
|---|---|
| AbstractList | xanthme oxidaseを阻害しfree radicalsの産生を抑制するallopurinolの投与と灌流の, 小腸の阻血と血流再開後の粘膜障害に対する保護効果を, 主に, イヌの小腸絨毛のNa+-K+ATPase活性の変化から検討し, 次の結論を得た.灌流またはsuperoxide産生阻害剤を投与しなかった群と灌流またはsuperoxide産生阻害剤の投与の単独実施群では, control群より有意 (p<0.05) にNa+-K+ATPase活性は低下した.superoxide産生阻害剤を投与し, 同時に灌流を実施した群ではその低下が有意 (p<0.05) に抑制された.したがって, 小腸の阻血と血流再開後の粘膜障害としてNa+-K+ATPase活性が低下すること, また, その原因としてfreeradicalsが関与し, さらに, superoxide産生阻害剤としてのallopurinolの投与は阻血と血流再開後の小腸粘膜の保護に有効であることを明らかにした. |
| Author | 高森, 正人 |
| Author_xml | – sequence: 1 fullname: 高森, 正人 organization: 金沢大学第2外科学教室 |
| BookMark | eNo9kEtLw0AAhBepYKy9-TcS95lsjlLqAwte9Bw2m6Q21CpJL96MaC-teFBKLQUfp4oQRFEEwT8TYpp_YYqPyzcMA8Mwi6DUPmi7ACwjqDFOyIrvN0INEw1jSueAggjlqkkMXAIKJFxXTUPnC6AShk0bQsaNwiMFbKVPF9Oz9ySK8-HH9O44iSYFv16jtHueD3rpZ7-IsufhtDvOR-M0fkmix3xwn0TXyUkvjW_yyWU2Os1ur7KHtyUw74lW6FZ-tQx212o71Q21vr2-WV2tqz5iWKiUSw_ZnkMhlYgUE4nNuJSQMq4jiA3KOZvRLWZiIoTE3IDYsZEDocEcm5RB7afXDzui4VqHQXNfBEeWCDpN2XKt2RPI1E0LE-sPxSn_udwTgeUL8g1j-3XC |
| ContentType | Journal Article |
| Copyright | 一般社団法人 日本消化器外科学会 |
| Copyright_xml | – notice: 一般社団法人 日本消化器外科学会 |
| DOI | 10.5833/jjgs.23.2244 |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1348-9372 |
| EndPage | 2250 |
| ExternalDocumentID | article_jjgs1969_23_9_23_9_2244_article_char_ja |
| GroupedDBID | 2WC ALMA_UNASSIGNED_HOLDINGS EBS EJD JSF KQ8 OK1 RJT |
| ID | FETCH-LOGICAL-j152a-48cf1bfd404c139373b58cc04586102748852748e00523aac28702db1d0075db3 |
| ISSN | 0386-9768 |
| IngestDate | Wed Sep 03 06:29:56 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 9 |
| Language | Japanese |
| License | https://creativecommons.org/licenses/by-nc/4.0/deed.ja |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j152a-48cf1bfd404c139373b58cc04586102748852748e00523aac28702db1d0075db3 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jjgs1969/23/9/23_9_2244/_article/-char/ja |
| PageCount | 7 |
| ParticipantIDs | jstage_primary_article_jjgs1969_23_9_23_9_2244_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 1990 |
| PublicationDateYYYYMMDD | 1990-01-01 |
| PublicationDate_xml | – year: 1990 text: 1990 |
| PublicationDecade | 1990 |
| PublicationTitle | 日本消化器外科学会雑誌 |
| PublicationTitleAlternate | 日消外会誌 |
| PublicationYear | 1990 |
| Publisher | 一般社団法人 日本消化器外科学会 |
| Publisher_xml | – name: 一般社団法人 日本消化器外科学会 |
| References | 2) Kawakami K, Noguchi S, Noda M et al: Primary structure of the alphasubunit of Torpedo kalifornica (Na+-K+) ATPase deduced from cDNA sequence. Nature 316: 733-736, 1985 5) Kato K, Yoshida K, Tsukamoto H et al: Synthesis of p-Nitorophenyl β-D-Glucopyranosiduronic acid and its utilization as a substrate for the assay of β-glucuronidase activity. Chem Pharm Bull 8: 239-242, 1960 12) Parks DA, Bulkley GB, Granger DN et al: Ischemic injury in the cat small intestine: Role of superoxide radicals. Gastroenterology 82: 9-15, 1982 8) Flick MR, Hoeffel J, Stanb NC: Superoxide dismutase prevents increased lung vascular permeability after air emboli in unanesthetized sheep. Fed Proc 40: 405, 1981 6) 大柳善彦: Establishment of Nitritekit for SOD activity determination. 炎症 4: 63-73, 1984 13) Johnson KJ, Fantone JC III, Kaplan J et al: In vivo damage of rat lungs by oxygen metabolites. J Clin Invest 67: 983-993, 1981 10) Flamm ES, Demopoulos HB, Seligman ML et al: Free radicals in cerebral ischemia. Stroke 9: 445-447, 1978 15) Noguchi S, Noda M, Takahashi H et al: Primary structure of the β-subunit of Torpedo california (Na+-K+)-ATPase deduced from the DNA sequence. Fed Eur Biochem Soc 196: 315-320, 1986 1) Granger DN, Rutili G, McCord JM: Superoxide radicals in feline intestinal ischemia. Gastroenterology 81: 22-29, 1981 9) Vasko KA, Dewall RA, Riley AM: Effect of allopurinol in renal ischemia. Surgery 71: 787-790, 1972 3) Charney AN, Donowitz M: Functional significance of intestinal Na+-K+ ATPase in vivo ouabain inhubition. Am J Physiol 234: 629-636, 1978 11) Willson R, Qualheim QE: A from of acate hemorrhagic enterocolitis afflicting cheonically ill individuals. A description of twenty cases. Gastroenterology 27: 431-444, 1954 16) Oberley LW, Buetner GR: Role of superoxide dismutase in cancer: A review. Cancer Res 39: 1141-1149. 1979 4) Oliver H, Lowry NJ, Rosebrough A et al: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951 7) Dewll RA, Vasko KA, Stanley EL et al: Responses of the ischemic myocardium to allopurinol. Am Heart J 82: 362-370, 1971 14) Post RL: A prespective on sodium and potassium ion transport adenosine triphosphatase. Cation Flux Across Biomembranes 19: 3-19, 1979 |
| References_xml | – reference: 2) Kawakami K, Noguchi S, Noda M et al: Primary structure of the alphasubunit of Torpedo kalifornica (Na+-K+) ATPase deduced from cDNA sequence. Nature 316: 733-736, 1985 – reference: 15) Noguchi S, Noda M, Takahashi H et al: Primary structure of the β-subunit of Torpedo california (Na+-K+)-ATPase deduced from the DNA sequence. Fed Eur Biochem Soc 196: 315-320, 1986 – reference: 16) Oberley LW, Buetner GR: Role of superoxide dismutase in cancer: A review. Cancer Res 39: 1141-1149. 1979 – reference: 3) Charney AN, Donowitz M: Functional significance of intestinal Na+-K+ ATPase in vivo ouabain inhubition. Am J Physiol 234: 629-636, 1978 – reference: 11) Willson R, Qualheim QE: A from of acate hemorrhagic enterocolitis afflicting cheonically ill individuals. A description of twenty cases. Gastroenterology 27: 431-444, 1954 – reference: 12) Parks DA, Bulkley GB, Granger DN et al: Ischemic injury in the cat small intestine: Role of superoxide radicals. Gastroenterology 82: 9-15, 1982 – reference: 7) Dewll RA, Vasko KA, Stanley EL et al: Responses of the ischemic myocardium to allopurinol. Am Heart J 82: 362-370, 1971 – reference: 4) Oliver H, Lowry NJ, Rosebrough A et al: Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951 – reference: 9) Vasko KA, Dewall RA, Riley AM: Effect of allopurinol in renal ischemia. Surgery 71: 787-790, 1972 – reference: 8) Flick MR, Hoeffel J, Stanb NC: Superoxide dismutase prevents increased lung vascular permeability after air emboli in unanesthetized sheep. Fed Proc 40: 405, 1981 – reference: 14) Post RL: A prespective on sodium and potassium ion transport adenosine triphosphatase. Cation Flux Across Biomembranes 19: 3-19, 1979 – reference: 1) Granger DN, Rutili G, McCord JM: Superoxide radicals in feline intestinal ischemia. Gastroenterology 81: 22-29, 1981 – reference: 5) Kato K, Yoshida K, Tsukamoto H et al: Synthesis of p-Nitorophenyl β-D-Glucopyranosiduronic acid and its utilization as a substrate for the assay of β-glucuronidase activity. Chem Pharm Bull 8: 239-242, 1960 – reference: 6) 大柳善彦: Establishment of Nitritekit for SOD activity determination. 炎症 4: 63-73, 1984 – reference: 10) Flamm ES, Demopoulos HB, Seligman ML et al: Free radicals in cerebral ischemia. Stroke 9: 445-447, 1978 – reference: 13) Johnson KJ, Fantone JC III, Kaplan J et al: In vivo damage of rat lungs by oxygen metabolites. J Clin Invest 67: 983-993, 1981 |
| SSID | ssib005879761 ssib000936942 ssib023160767 ssib058493923 ssj0000491391 ssib002223853 |
| Score | 1.3501755 |
| Snippet | xanthme oxidaseを阻害しfree radicalsの産生を抑制するallopurinolの投与と灌流の, 小腸の阻血と血流再開後の粘膜障害に対する保護効果を, 主に, イヌの小腸絨毛のNa+-K+ATPase活性の変化から検討し,... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 2244 |
| Title | 小腸の阻血と血流再開後の粘膜障害に関する実験的研究 |
| URI | https://www.jstage.jst.go.jp/article/jjgs1969/23/9/23_9_2244/_article/-char/ja |
| Volume | 23 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本消化器外科学会雑誌, 1990, Vol.23(9), pp.2244-2250 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Na9RAFA-1XryIouI3PTgnyZrMTJKZi5DJZikWBaGF3kI-NsIeatHtxZMr2ksVD0qppeDHqSIsolgEwX9mWXf3v_C9SbJNoQerXoaXN5PfvDczyXsvmQ_DuJalXh5nXJqUppbJ3XZqJsLiZoa_cu08d6Q-ReH2HXd-id9adpZnju3VZi2tdZNG-ujQdSV_06vAg37FVbJH6NkpKDCAhv6FFHoY0j_qYxI6RFlEtEgoiABakJCBb0j8kISSSEGUwizfxgkNZZaocVyiHGQCjnCJaOq7gFAaOSQiqAF6RFHExLpcIgNd2NeEgwUUqwqrEsenJUdKTdASGQrLFpYBYSRDZMARHAnfIrIgJFFu3XVGaSXwHU0ExA-0_CCt0PIHWCMQUsNiLVxz4BbA1zr6TeIDhxMVYI0opNJZ0CAgwPSDsRZNaV1BCYbywkjUF028RgSflJ84snINoTUd3jpf6AYWKB1K6qE40KIooNIYLjaYdKZg1_-7grWXPBOuCS5hYYPahRFiHIwQ8w5YqWJVdvk0yrrJocUGmqX7Au9n6zDTiKvr0DR27j1sUNbYv-vAZuPlUI6wGG6cFFEWVQncEVX5uCQw6kBccpx6no1TaRfu1tx6PCWS1_7Wgw9adwsd4YHKU7sCIYZreftuMPjEklVhfaeIYiFQ0YdfVs1VrGFBpW7UVQI_sgNRVTUjUzuJi6eMk2V0N-cX8p82ZjrxGWNh-Pnl-Nn3Qa8_2foxfv940NuF9Ne33nD9xWRzY_jzOWSNvmyN13cm2zvD_tdB79Nk88Og92bwZGPYfzvZfTXafjp693r0ce-ssdQKF4N5szzDxOyAZxybXKS5neQZt3hq4-aTLHFEmuL0BAhcqAf208G0rf_PxHGKEw9oltgZOvNZws4Zsyv3V9rnjTmZS2F5iSVFmnAXD51LMorHLdgspyKWF4ybhe7RarFRTXTE3rz4rwCXjBP4uBVfKC8bs90Ha-0r4LN3k6t6gPwGIY675g |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E5%B0%8F%E8%85%B8%E3%81%AE%E9%98%BB%E8%A1%80%E3%81%A8%E8%A1%80%E6%B5%81%E5%86%8D%E9%96%8B%E5%BE%8C%E3%81%AE%E7%B2%98%E8%86%9C%E9%9A%9C%E5%AE%B3%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E5%AE%9F%E9%A8%93%E7%9A%84%E7%A0%94%E7%A9%B6&rft.jtitle=%E6%97%A5%E6%9C%AC%E6%B6%88%E5%8C%96%E5%99%A8%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A%E9%9B%91%E8%AA%8C&rft.au=%E9%AB%98%E6%A3%AE%2C+%E6%AD%A3%E4%BA%BA&rft.date=1990&rft.pub=%E4%B8%80%E8%88%AC%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E6%B6%88%E5%8C%96%E5%99%A8%E5%A4%96%E7%A7%91%E5%AD%A6%E4%BC%9A&rft.issn=0386-9768&rft.eissn=1348-9372&rft.volume=23&rft.issue=9&rft.spage=2244&rft.epage=2250&rft_id=info:doi/10.5833%2Fjjgs.23.2244&rft.externalDocID=article_jjgs1969_23_9_23_9_2244_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0386-9768&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0386-9768&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0386-9768&client=summon |