6315-S (FLOMOXEF) IN UROLOGY

• Published in: CHEMOTHERAPY Vol. 35; no. Supplement1; pp. 1094 - 1101
• Main Authors: UEMA, KENZO, ODACHI, MOTOAKI, KUROKAWA, KAZUO, IMAGAWA, AKIO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 31.05.1987
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.35.Supplement1_1094

6315-S (flomoxef) was used in the treatment of urinary and genital infections to investigate its clinical efficacy and safety. The subjects were: 1 patient with acute uncomplicated pyelonephritis, 11 patients with chronic complicated pyelonephritis, 11 with chronic complicated cystitis and 3 with acute prostatitis. The drug was administered by single i. v. injection or by 1. v. drip infusion in a daily dose of 1 or 2g in two divided doses, morning and evening. 1) The results were as follows. Clinical efficacy in chronic complicated urinary tract infections, applying the Japanese UTI Committee's “Criteria for Evaluation of Drug Efficacy in UTI” was: excellent in 6 patients, good in 7 an poor in 7; an overall efficacy rate of 65%. Measured by group, the rate was 100% for Group 1, 60% for Group 2, 100% for Group 3, 100% for Group 4, 0% for Group 5 and 60% for Group 6. By type of infection, the efficacy rate was 83% for single and 38% for mixed infections. Again, the rate was 25% in cases with and 75% in cases without indwelling catheter. 2) Bacteriologically, 25 out of 31 strains (81%) were eradicated. The bacteria appearing after treatment were five strains of P. aeruginosa, P. cepacia and S. liquefaciens. 3) The results of assessment by the doctor in charge were: good in 1 patient with acute uncomplicated pyelonephritis, and excellent in 3 patients with acute prostatitis. 4) Neither subjective nor objective side-effects were found. Abnormal changes in laboratory values on which the influence of the drug could not be ruled out, were found in 3 patients (S-GPT, 1; S-GOT and S-GPT, 2) but none wereserious. The above results suggest that 6315-S is a useful drug for the treatment of urinary and genital infections.