CETPと動脈硬化 CETP欠損症の抗動脈硬化性は血清HDLコレステロール値に依存する
Heterozygous CETP deficiency is found in ∼10% of the general Japanese population, and is an important genetic factor of increased HDL levels. A crosssectional epidemiologic survey in Kochi prefecture showed that subjects with very high HDL cholesterol levels≥80mg/dl exhibit a low CHD prevalence, irr...
Saved in:
| Published in | 動脈硬化 Vol. 26; no. 3; pp. 133 - 139 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本動脈硬化学会
30.11.1998
Japan Atherosclerosis Society |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-2682 2185-8284 |
| DOI | 10.5551/jat1973.26.3_133 |
Cover
| Abstract | Heterozygous CETP deficiency is found in ∼10% of the general Japanese population, and is an important genetic factor of increased HDL levels. A crosssectional epidemiologic survey in Kochi prefecture showed that subjects with very high HDL cholesterol levels≥80mg/dl exhibit a low CHD prevalence, irrespective of the CETP genotype. The cholesterol esterification rate was decreased in both homo- and heterozygous CETP deficiency. Increased levels of HDL itself, along with low non-HDL cholesterol levels, manifest anti-atherogenicity in subjects with very high HDL levels and CETP deficiency, possibly through direct effects of HDL on the arterial wall or an antioxidative mechanism. However, normolipidemic elderly men with low-to-intermediate HDL-C levels (<60mg/dl) and a D442G mutation, demonstrated ischemic ST-T change 3times more frequently. Thus, antiatherogenicity of CETP deficiency is dependent on serum HDL-C levels, and CETP genotyping/serum CETP measurement may be useful to identify a high-risk grop in subjects with serum HDL-C<60mg/dl. |
|---|---|
| AbstractList | Heterozygous CETP deficiency is found in ∼10% of the general Japanese population, and is an important genetic factor of increased HDL levels. A crosssectional epidemiologic survey in Kochi prefecture showed that subjects with very high HDL cholesterol levels≥80mg/dl exhibit a low CHD prevalence, irrespective of the CETP genotype. The cholesterol esterification rate was decreased in both homo- and heterozygous CETP deficiency. Increased levels of HDL itself, along with low non-HDL cholesterol levels, manifest anti-atherogenicity in subjects with very high HDL levels and CETP deficiency, possibly through direct effects of HDL on the arterial wall or an antioxidative mechanism. However, normolipidemic elderly men with low-to-intermediate HDL-C levels (<60mg/dl) and a D442G mutation, demonstrated ischemic ST-T change 3times more frequently. Thus, antiatherogenicity of CETP deficiency is dependent on serum HDL-C levels, and CETP genotyping/serum CETP measurement may be useful to identify a high-risk grop in subjects with serum HDL-C<60mg/dl. |
| Author | 黄, 志平 岡村, 智教 森山, ゆり 馬, 渕宏 稲津, 明広 小泉, 順二 |
| Author_FL | KOIZUMI Junji MORIYAMA Yuri OKAMURA Tomonori MABUCHI Hiroshi INAZU Akihiro HUANG Zhiping |
| Author_FL_xml | – sequence: 1 fullname: INAZU Akihiro – sequence: 2 fullname: HUANG Zhiping – sequence: 3 fullname: KOIZUMI Junji – sequence: 4 fullname: MORIYAMA Yuri – sequence: 5 fullname: OKAMURA Tomonori – sequence: 6 fullname: MABUCHI Hiroshi |
| Author_xml | – sequence: 1 fullname: 稲津, 明広 organization: 金沢大学保健学科医学検査学 – sequence: 1 fullname: 黄, 志平 organization: 金沢大学医学部第二内科 – sequence: 1 fullname: 小泉, 順二 organization: 金沢大学総合診療部 – sequence: 1 fullname: 馬, 渕宏 organization: 金沢大学医学部第二内科 – sequence: 1 fullname: 森山, ゆり organization: 高知県衛生研究所保健科学部 – sequence: 1 fullname: 岡村, 智教 organization: 大阪府立成人病センター集団検診第1部 |
| BackLink | https://cir.nii.ac.jp/crid/1570854174393653248$$DView record in CiNii |
| BookMark | eNo9kL1KA0EUhQdRMMZUNj6A7cY799752VKW-AMBLWI9zM7O6IYYZTeNpWAhaKu9nYVvJUEfw5UEm3OK83HgnB2xOb-dRyH2JQyVUvJw6hcyNzREPSQniTZED6VVmUXLm6IHZHWG2uK2GLRtXQJAbjoAe2KvGE0uvh4-ls-vP49P3--fy5e3XbGV_KyNg7X3xeXxaFKcZuPzk7PiaJxNJWubUYkmcYiWIyaA0qeQGwMRAgFCqKrSM5PUHHPEChhMKnPgKiXFVoKmvjhY9c7r2oX6T6UyYBVLw5STVoRsO6xYYdN24a-iu2vqG9_cO98s6jCLbj3eoXZr6R74T8O1bzqEfgGgg1dD |
| ContentType | Journal Article |
| Copyright | 一般社団法人 日本動脈硬化学会 |
| Copyright_xml | – notice: 一般社団法人 日本動脈硬化学会 |
| DBID | RYH |
| DOI | 10.5551/jat1973.26.3_133 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Cholesteryl Ester Transfer Protein (CETP) and Atherogenicity. Anti-atherogenicity of CETP deficiency is dependent on serum HDL cholesterol levels |
| DocumentTitle_FL | Cholesteryl Ester Transfer Protein (CETP) and Atherogenicity. Anti-atherogenicity of CETP deficiency is dependent on serum HDL cholesterol levels |
| EISSN | 2185-8284 |
| EndPage | 139 |
| ExternalDocumentID | 10005904754 article_jat1973_26_3_26_3_133_article_char_ja |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF KQ8 RJT RYH |
| ID | FETCH-LOGICAL-j1468-3b27f4ce84e2f00bafc9770e0c3020cddba443164e922d0407fb904dff5481063 |
| ISSN | 0386-2682 |
| IngestDate | Fri Jun 27 00:29:08 EDT 2025 Wed Sep 03 06:25:26 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 3 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j1468-3b27f4ce84e2f00bafc9770e0c3020cddba443164e922d0407fb904dff5481063 |
| ORCID | 0000-0001-9857-5686 0000-0003-0488-0351 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jat1973/26/3/26_3_133/_article/-char/ja |
| PageCount | 7 |
| ParticipantIDs | nii_cinii_1570854174393653248 jstage_primary_article_jat1973_26_3_26_3_133_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 1998-11-30 |
| PublicationDateYYYYMMDD | 1998-11-30 |
| PublicationDate_xml | – month: 11 year: 1998 text: 1998-11-30 day: 30 |
| PublicationDecade | 1990 |
| PublicationTitle | 動脈硬化 |
| PublicationTitleAlternate | 動脈硬化 |
| PublicationTitle_FL | The Journal of Japan Atherosclerosis Society |
| PublicationYear | 1998 |
| Publisher | 一般社団法人 日本動脈硬化学会 Japan Atherosclerosis Society |
| Publisher_xml | – name: 一般社団法人 日本動脈硬化学会 – name: Japan Atherosclerosis Society |
| References | 5) Inazu A, Jiang XC, Haraki T, Yagi K, Kamon N, Koizumi J, Mabuchi H, Takeda R, Takata K, Moriyama Y, Doi M, and Tall A: Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest, 94: 1872-1882, 1994 17) Duverger N, Rader D, Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Nagano M, Nakamura H, and Brewer HB Jr: Characterization of high-density apolipoprotein particles A-I and A-I: A-II isolated from humans with cholesteryl ester transfer protein deficiency. Eur J Biochem, 227: 123-129, 1995 14) 千葉仁志, 秋田治邦, 小谷一夫, 菅野剛史, 真鍋満久: コレステリルエステル転送蛋白欠損は酸化LDLを増加させる. 臨床病理, 45: 55-57, 1997 21) Zhong S, Sharp DS, Grove JS, Bruce C, Yano K, Curb JD, and Tall AR: Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increasd HDL levels. J Clin Invest, 97: 2917-2923, 1996 16) 三井田孝, 稲野浩一, 中村裕一, 松戸隆之, 星山真理, 金子兼三, 岡田正彦: コレステリルエステル転送蛋白 (CETP) 欠損症におけるHDL亜分画異常の検討. 臨床病理, 44: 865-870, 1996 7) 稲津明広, 小泉順二, 馬渕宏: CETP欠損と高HDLコレステロール血症. 臨床病理, 44: 322-326, 1996 6) Song GJ, Han GH, Chae ii, Namkoong Y, Lee HK, Park YB, and Lee CC: The effects of the cholesteryl ester transfer protein gene and environmental factors on the plasma high density lipoprotein cholesterol levels in the Korean population. Mol Cells, 7: 615-619, 1997 20) Hirano K-I, Yamashita S, Nakajima N, Arai T, Maruyama T, Yoshida Y, Ishigami M, Sakai N, Kameda-Takemura K, and Matsuzawa Y: Genetic cholesteryl ester transfer protein deficiency in extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol, 17: 1053-1059, 1997 8) Koizumi J, Inazu A, Yagi K, Koizumi I, Uno Y, Kajinami K, Miyamoto S, Moulin P, Tall AR, Mabuchi H, and Takeda R: Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiency. Atherosclerosis, 90: 189-196, 1991 1) Tall A: Plasma lipid transfer proteins. Annu Rev Biochem, 64: 235-257, 1995 4) Brown ML, Inazu A, Hesler CB, Agellon LB, Mann C, Whitlock ME, Marcel YL, Mime RW, Koizumi J, Mabuchi H, Takeda R, and Tall AR: Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoprotiens. Nature, 342: 448-451, 1989 2) Kiyohara T, Kiriyama R, Zamma S, Inazu A, Koizumi J, Mabuchi H, and Chichibu K: Enzyme immunoassay for cholesteryl ester transfer protein in human serum. Clin Chim Acta, 271: 109-118, 1998 10) Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer JR, Ishikawa T, Fairwell T, Zech LA, Nakamura H, Nagano M, and Brewer HB Jr: Delayed catabolism of high density lipoprotein apolipoprotein A-I and A-II in human cholesteryl ester transfer protein deficiency. J Clin Invest, 92: 1650-1658, 1993 19) Moriyama Y, Okamura T, Inazu A, Doi M, Iso H, Mouri Y, Ishikawa Y, Suzuki H, Iida M, Koizumi J, Mabuchi H, and Komachi Y: A low prevalence of coronary heart desease in subjects with increased highdensity lipoprotein cholesterol levels including those with plasma cholesteryl ester transfer protein deficiency. Prey Med, in press, 1998 12) Sugano M, Makino N, Sawada S, Otsuka S, Watanabe M, Okamoto H, Kamada M, and Mizushima A: Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J Biol Chem, 273: 5033-5036, 1998 24) Miyashita Y, Morimoto S, Fukuo K, Imanaka S, Koh E, Tamatani M, and Ogihara T: Participation of decreased serum cholesteryl ester transfer activity, independent of increased serum lipoprotein (a), in angina pectoris in normolipemic elderly subjects. Gerontology, 38: 258-267, 1992 23) Kuivenhoven JA, Jukema JW, Zwinderman AH, De Knijlf P, McPherson R, Bruschke AVG, Lie KI, and Kastelein JJP for the regression growth evaluation statin study group: The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. N Engl J Med, 338: 86-93, 1998 3) Koizumi J, Mabuchi H, Yoshimura A, Michishita I, Takeda M, Itoh H, Sakai Y, Sakai T, Ueda K, and Takeda R: Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinemia. Atherosclerosis, 58: 175-186, 1985 22) Fumeron F, Betoulle D, Luc G, Behague I, Ricard S, Poirier O, Jemma R, Evans A, Arveiler D, Marques-Vidal P, Bard J-M, Fruchart J-C, Ducimetiere P, Apfelbaum M, and Cambien F: Alcohol intake modulates the effect of a polymorphism of the CETP gene on plasma HDL and the risk of myocardial infarction. J Clin Invest, 96: 1664-1671, 1995 25) Hibino T, Sakuma N, and Sato T: Higher level of plasma cholesteryl ester transfer activity from highdensity lipoprotein to apo-B containing lipoproteins in subjects with angiographically detectable coronary artery disease. Clin Cardiol, 19: 483-486, 1996 15) Oliveira HCF, Ma L, Mime R, Marcovina SM, Inazu A, Mabuchi H, and Tall AR: Cholesteryl ester transfer protein (CETP) activity enhances plasma cholesteryl ester formation: studies in CETP transgenic mice and human genetic CETP deficiency. Arterioscler Thromb Vasc Biol, 17: 1045-1052, 1997 11) Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech LA, Nagano M, Nakamura H, Brewer HB Jr, and Rader DJ: Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency. J Clin Invest, 96: 1573-1581, 1995 18) Hirano K-I, Yamashita S, Kuga Y, Sakai N, Nozaki S, Kihara S, Arai T, Yanagi K, Takami S, Menju M, Ishigami M, Yoshida Y, Kameda-Takemura K, Hayashi K, and Matsuzawa Y: Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler Thromb Vasc Biol, 15: 1849-1856, 1995 13) Ohta T, Nakamura R, Takata K, Saito Y, Yamashita S, Horiuchi S, and Matsuda I: Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency. J Lipid Res, 36: 696-704, 1995 9) Bisgaier CL, Siebenkas MV, Brown ML, Inazu A, Koizumi J, Mabuchi H, and Tall AR: Familial cholesteryl ester transfer protein deficiency is associated with triglyceride-rich low denstty lipoproteins containing cholesteryl ester of probable intracellular origin. J Lipid Res, 32: 21-30, 1991 |
| References_xml | – reference: 21) Zhong S, Sharp DS, Grove JS, Bruce C, Yano K, Curb JD, and Tall AR: Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increasd HDL levels. J Clin Invest, 97: 2917-2923, 1996 – reference: 5) Inazu A, Jiang XC, Haraki T, Yagi K, Kamon N, Koizumi J, Mabuchi H, Takeda R, Takata K, Moriyama Y, Doi M, and Tall A: Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest, 94: 1872-1882, 1994 – reference: 12) Sugano M, Makino N, Sawada S, Otsuka S, Watanabe M, Okamoto H, Kamada M, and Mizushima A: Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J Biol Chem, 273: 5033-5036, 1998 – reference: 14) 千葉仁志, 秋田治邦, 小谷一夫, 菅野剛史, 真鍋満久: コレステリルエステル転送蛋白欠損は酸化LDLを増加させる. 臨床病理, 45: 55-57, 1997 – reference: 10) Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer JR, Ishikawa T, Fairwell T, Zech LA, Nakamura H, Nagano M, and Brewer HB Jr: Delayed catabolism of high density lipoprotein apolipoprotein A-I and A-II in human cholesteryl ester transfer protein deficiency. J Clin Invest, 92: 1650-1658, 1993 – reference: 2) Kiyohara T, Kiriyama R, Zamma S, Inazu A, Koizumi J, Mabuchi H, and Chichibu K: Enzyme immunoassay for cholesteryl ester transfer protein in human serum. Clin Chim Acta, 271: 109-118, 1998 – reference: 6) Song GJ, Han GH, Chae ii, Namkoong Y, Lee HK, Park YB, and Lee CC: The effects of the cholesteryl ester transfer protein gene and environmental factors on the plasma high density lipoprotein cholesterol levels in the Korean population. Mol Cells, 7: 615-619, 1997 – reference: 24) Miyashita Y, Morimoto S, Fukuo K, Imanaka S, Koh E, Tamatani M, and Ogihara T: Participation of decreased serum cholesteryl ester transfer activity, independent of increased serum lipoprotein (a), in angina pectoris in normolipemic elderly subjects. Gerontology, 38: 258-267, 1992 – reference: 18) Hirano K-I, Yamashita S, Kuga Y, Sakai N, Nozaki S, Kihara S, Arai T, Yanagi K, Takami S, Menju M, Ishigami M, Yoshida Y, Kameda-Takemura K, Hayashi K, and Matsuzawa Y: Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler Thromb Vasc Biol, 15: 1849-1856, 1995 – reference: 8) Koizumi J, Inazu A, Yagi K, Koizumi I, Uno Y, Kajinami K, Miyamoto S, Moulin P, Tall AR, Mabuchi H, and Takeda R: Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiency. Atherosclerosis, 90: 189-196, 1991 – reference: 3) Koizumi J, Mabuchi H, Yoshimura A, Michishita I, Takeda M, Itoh H, Sakai Y, Sakai T, Ueda K, and Takeda R: Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinemia. Atherosclerosis, 58: 175-186, 1985 – reference: 13) Ohta T, Nakamura R, Takata K, Saito Y, Yamashita S, Horiuchi S, and Matsuda I: Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency. J Lipid Res, 36: 696-704, 1995 – reference: 25) Hibino T, Sakuma N, and Sato T: Higher level of plasma cholesteryl ester transfer activity from highdensity lipoprotein to apo-B containing lipoproteins in subjects with angiographically detectable coronary artery disease. Clin Cardiol, 19: 483-486, 1996 – reference: 22) Fumeron F, Betoulle D, Luc G, Behague I, Ricard S, Poirier O, Jemma R, Evans A, Arveiler D, Marques-Vidal P, Bard J-M, Fruchart J-C, Ducimetiere P, Apfelbaum M, and Cambien F: Alcohol intake modulates the effect of a polymorphism of the CETP gene on plasma HDL and the risk of myocardial infarction. J Clin Invest, 96: 1664-1671, 1995 – reference: 23) Kuivenhoven JA, Jukema JW, Zwinderman AH, De Knijlf P, McPherson R, Bruschke AVG, Lie KI, and Kastelein JJP for the regression growth evaluation statin study group: The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. N Engl J Med, 338: 86-93, 1998 – reference: 9) Bisgaier CL, Siebenkas MV, Brown ML, Inazu A, Koizumi J, Mabuchi H, and Tall AR: Familial cholesteryl ester transfer protein deficiency is associated with triglyceride-rich low denstty lipoproteins containing cholesteryl ester of probable intracellular origin. J Lipid Res, 32: 21-30, 1991 – reference: 17) Duverger N, Rader D, Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Nagano M, Nakamura H, and Brewer HB Jr: Characterization of high-density apolipoprotein particles A-I and A-I: A-II isolated from humans with cholesteryl ester transfer protein deficiency. Eur J Biochem, 227: 123-129, 1995 – reference: 20) Hirano K-I, Yamashita S, Nakajima N, Arai T, Maruyama T, Yoshida Y, Ishigami M, Sakai N, Kameda-Takemura K, and Matsuzawa Y: Genetic cholesteryl ester transfer protein deficiency in extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol, 17: 1053-1059, 1997 – reference: 16) 三井田孝, 稲野浩一, 中村裕一, 松戸隆之, 星山真理, 金子兼三, 岡田正彦: コレステリルエステル転送蛋白 (CETP) 欠損症におけるHDL亜分画異常の検討. 臨床病理, 44: 865-870, 1996 – reference: 15) Oliveira HCF, Ma L, Mime R, Marcovina SM, Inazu A, Mabuchi H, and Tall AR: Cholesteryl ester transfer protein (CETP) activity enhances plasma cholesteryl ester formation: studies in CETP transgenic mice and human genetic CETP deficiency. Arterioscler Thromb Vasc Biol, 17: 1045-1052, 1997 – reference: 7) 稲津明広, 小泉順二, 馬渕宏: CETP欠損と高HDLコレステロール血症. 臨床病理, 44: 322-326, 1996 – reference: 11) Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech LA, Nagano M, Nakamura H, Brewer HB Jr, and Rader DJ: Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency. J Clin Invest, 96: 1573-1581, 1995 – reference: 4) Brown ML, Inazu A, Hesler CB, Agellon LB, Mann C, Whitlock ME, Marcel YL, Mime RW, Koizumi J, Mabuchi H, Takeda R, and Tall AR: Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoprotiens. Nature, 342: 448-451, 1989 – reference: 19) Moriyama Y, Okamura T, Inazu A, Doi M, Iso H, Mouri Y, Ishikawa Y, Suzuki H, Iida M, Koizumi J, Mabuchi H, and Komachi Y: A low prevalence of coronary heart desease in subjects with increased highdensity lipoprotein cholesterol levels including those with plasma cholesteryl ester transfer protein deficiency. Prey Med, in press, 1998 – reference: 1) Tall A: Plasma lipid transfer proteins. Annu Rev Biochem, 64: 235-257, 1995 |
| SSID | ssib000972182 ssj0003239275 ssib002821934 |
| Score | 1.480289 |
| Snippet | Heterozygous CETP deficiency is found in ∼10% of the general Japanese population, and is an important genetic factor of increased HDL levels. A crosssectional... |
| SourceID | nii jstage |
| SourceType | Publisher |
| StartPage | 133 |
| SubjectTerms | Cholesteryl ester transfer protein Coronary heart disease Genetic epidemiology High density liprotein Reverse cholesterol transport Risk factor |
| Subtitle | CETP欠損症の抗動脈硬化性は血清HDLコレステロール値に依存する |
| Title | CETPと動脈硬化 |
| URI | https://www.jstage.jst.go.jp/article/jat1973/26/3/26_3_133/_article/-char/ja https://cir.nii.ac.jp/crid/1570854174393653248 |
| Volume | 26 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 動脈硬化, 1998/11/30, Vol.26(3), pp.133-139 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RAdGjrxYsoKlat9OCcltQkk48Z8JLsZin1A4UWegtJNoHtYSt2e_G0H35hFbxo9SBYEBTa6sGLgvgD_BvjbvszfDOZ7KZFaBXCMLyvybyXybw3mXlB6CpNs1ikctIMs8E0K0kdLQKvWgNbZ66IR1hDrHfcuu3ML1kLy_byxOSv0q6l9XY8lzz467mS_7EqwMCu4pTsP1h2JBQAUAf7QgkWhvJYNq4Gi3dwQMAbxB7FgY2pj5mNA4opuIgAcbEHqKpEVTFztJzDETBPFxWmY1oThMzF1C2EBQJFPQE8hlRJrGNvxF4XxEBDZRM-MNrztZsSa2KfyAqREnIIUxDqFKiaqvjVAuLL5qAVq2gFIBb2A8xqAgUsjCoUY0oy9cvO93H6UsGkJrehlFJqLIBD0ap4wlVeXQMTQNlcK_a7Fk-sFEWxb8ouW9izK1K_0FIgpPsepmRMzLDvwz1UJKquFA2K8Es0AADr1KVA6A6rCDYwm1CTJQVWx8RgUyINB1wGXJVCBU5R8cYrPPLIo8osWcy-R3ZSnX-jjmY69MDclmcjUGOYlCYqI08_onweI08odXg6tcGdlr9xaBvMJXOmM0fCEeOBJOVGngjIguE9iU6Yriu3TNy4W3L1RZooeuALPsQO1mg9lJjgqcu82KOO5LsKxE1cO3wL4C-uQPQk0mJMtprNkku4eBqdUrHcrJcPzDNoYiU6i5piiPHup8HGq_2HT_e2dgbPX8thN9x5P3z5Ym_zCe9-Hj7bLOOHnY-8-2V_qzP89ggGCu995f0d3vvO-495f5f3f_D-9qDzgXe3f_98N9h9w7tveW_jHFqqB4vVeU39z0RbkQccSWy6GbwOqZWama7HUZZA9KWnekIgaEsajTiyRGYKK2Wm2YDZ1c1i0Gkjy2yLGvBGPY-mWqut9AKatZ04i6htxoRCCJSlLHFhcmbig0ZkZGk0ja7n-gnv5UlrQvWSCpUmQ9MJVQHqHGHFUU8gmUYzoNUwaYrSsF2Iyyy5dEEcGyIwevEI_CV0cvwgX0ZT7fvr6Qw47-34inwq_gDyT8g3 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CETP%E3%81%A8%E5%8B%95%E8%84%88%E7%A1%AC%E5%8C%96-CETP%E6%AC%A0%E6%90%8D%E7%97%87%E3%81%AE%E6%8A%97%E5%8B%95%E8%84%88%E7%A1%AC%E5%8C%96%E6%80%A7%E3%81%AF%E8%A1%80%E6%B8%85HDL%E3%82%B3%E3%83%AC%E3%82%B9%E3%83%86%E3%83%AD%E3%83%BC%E3%83%AB%E5%80%A4%E3%81%AB%E4%BE%9D%E5%AD%98%E3%81%99%E3%82%8B&rft.jtitle=%E5%8B%95%E8%84%88%E7%A1%AC%E5%8C%96+%3D+The+journal+of+Japan+Atherosclerosis+Society&rft.au=%E7%A8%B2%E6%B4%A5+%E6%98%8E%E5%BA%83&rft.au=%E9%BB%84+%E5%BF%97%E5%B9%B3&rft.au=%E5%B0%8F%E6%B3%89+%E9%A0%86%E4%BA%8C&rft.au=%E6%A3%AE%E5%B1%B1+%E3%82%86%E3%82%8A&rft.date=1998-11-30&rft.pub=Japan+Atherosclerosis+Society&rft.issn=0386-2682&rft.volume=26&rft.issue=3&rft.spage=133&rft.epage=139&rft_id=info:doi/10.5551%2Fjat1973.26.3_133&rft.externalDocID=10005904754 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0386-2682&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0386-2682&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0386-2682&client=summon |