A Case of Secondary Leukemia Having t (9; 11) and MLL Gene Rearrangement Possibly Due to Etoposide
We report a case of non-lymphocytic leukemia which was considered to be related to etoposide containing chemotherapy for relapsed acute lymphoblastic leukemia (ALL). A 10-year-old boy was admitted in our department in April 1988 because of bone pain and was diagnosed as having common ALL with normal...
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| Published in | The Japanese Journal of Pediatric Hematology Vol. 8; no. 6; pp. 532 - 536 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY
1994
特定非営利活動法人 日本小児血液・がん学会 |
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| Online Access | Get full text |
| ISSN | 0913-8706 1884-4723 |
| DOI | 10.11412/jjph1987.8.532 |
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| Abstract | We report a case of non-lymphocytic leukemia which was considered to be related to etoposide containing chemotherapy for relapsed acute lymphoblastic leukemia (ALL). A 10-year-old boy was admitted in our department in April 1988 because of bone pain and was diagnosed as having common ALL with normal karyotype. He was treated by our standard risk ALL protocol (UH-8201) until December 1990, but he had bone marrow and testicular relapse 2 months after off-therapy and was treated by the PVDA and BFM rez87 regimen until December 1991. Blast cells appeared in peripheral blood in July 1992. Blast cells in that time changed to monocytoid appearance with t (9; 11) (p22; q23) and the rearrangement of MLL gene. Therefore this case was considered secondary leukemia related to etoposide used in a chemotherapy regimen. The total cumulative dose of etoposide was 1, 060 mg/m2. |
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| AbstractList | We report a case of non-lymphocytic leukemia which was considered to be related to etoposide containing chemotherapy for relapsed acute lymphoblastic leukemia (ALL). A 10-year-old boy was admitted in our department in April 1988 because of bone pain and was diagnosed as having common ALL with normal karyotype. He was treated by our standard risk ALL protocol (UH-8201) until December 1990, but he had bone marrow and testicular relapse 2 months after off-therapy and was treated by the PVDA and BFM rez87 regimen until December 1991. Blast cells appeared in peripheral blood in July 1992. Blast cells in that time changed to monocytoid appearance with t (9; 11) (p22; q23) and the rearrangement of MLL gene. Therefore this case was considered secondary leukemia related to etoposide used in a chemotherapy regimen. The total cumulative dose of etoposide was 1, 060 mg/m2.
われわれは, etoposideを含むALL再発治療regimen後に発症し, MLL遺伝子の再構成を認めた急性非リンパ球性白血病の症例を経験したので報告する.症例は10歳の男県で1988年4月に骨痛を主訴に当科を受診し, 精査によりCD10, CD19陽性のALLとして入院加療となった.1990年12月に治療が終了したが, その2カ月後, 骨髄と睾丸の再発をきたし, PVDA-III regimen, BFM rez87 regimenを施行し, 寛解が維持できたためプロトコールに従い1991年12月治療を終了した.初発時および再発時の芽球に特異的染色体異常を認めなかった.1992年7月, 末梢血に芽球が出現し;そのときの芽球は単球様で, t (9;11) (p22;q23) の染色体異常があり, MLL遺伝子の再構成を認めたのでetoposideによる二次性白血病と診断した.本患児へのetoposideの総投与量は1,060mg/m2であった. We report a case of non-lymphocytic leukemia which was considered to be related to etoposide containing chemotherapy for relapsed acute lymphoblastic leukemia (ALL). A 10-year-old boy was admitted in our department in April 1988 because of bone pain and was diagnosed as having common ALL with normal karyotype. He was treated by our standard risk ALL protocol (UH-8201) until December 1990, but he had bone marrow and testicular relapse 2 months after off-therapy and was treated by the PVDA and BFM rez87 regimen until December 1991. Blast cells appeared in peripheral blood in July 1992. Blast cells in that time changed to monocytoid appearance with t (9; 11) (p22; q23) and the rearrangement of MLL gene. Therefore this case was considered secondary leukemia related to etoposide used in a chemotherapy regimen. The total cumulative dose of etoposide was 1, 060 mg/m2. |
| Author | ARAI, Koji HAYASHI, Yasuhide KASAI, Mikio YOKOYAMA, Masaru ITO, Etsuro SATO, Yuichi WATANABE, Junko ECHIZENYA, Taketora SUTO, Yoshimasa |
| Author_FL | 伊藤 悦朗 越前屋 竹寅 佐藤 雄一 横山 雄 荒井 宏治 須藤 善雅 葛西 幹雄 林 泰秀 渡辺 潤子 |
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| Publisher | THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 特定非営利活動法人 日本小児血液・がん学会 |
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| References | 2) Pui CH, Ribeiro RG, Hancock ML, et al : Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 325 : 1682-1687, 1991 16) Tkachuk DC, Kohler S, Cleary ML : Involvement of a homolog of drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71 : 691-700, 1992 18) Corral J, Forster A, Thompson S, et al : Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 90 : 8539-8542, 1993 4) Rivera GK, Buchanan G, Boyett JM, et al : Intensive retreatmant of childhood acute lymphoblastic leukemia in first bone marrow relapse. N Engl J Med 315 : 275-278, 1986 6) Yamamoto K, Seto M, Akao Y, et al : Gene rearrangement and truncated mRNA in cell lines with 11q23 translocation. Oncogene 8 : 479-485, 1993 10) 林泰秀, 稲葉俊哉, 花田良二, 他 : 乳児急性白血病の染色体所見と臨床像.日児誌95 : 2394-2400, 1991 5) Henze G, Frengler R, Hartmann R, et al : BFM results in relapsed childhood acute lymphoblastic leukemia. Haematology and blood transfusion Vol 33 Acute leukemia II, Buchner T ed Springer-Verlag Berlin 1990,619-626 8) Chak LY, Sikic BI, Tucker MA, et al : Increasedincidence of acute nonlymphocytic leukemia following therapy in patient with small cell carcinoma of the lung. J Clin Oncol 2 : 385-390, 1984 13) van der Poel S, McCabe R, Cill J, et al : Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88 : 10735-10739, 1991 7) Tucker MA, Coleman CN, Cox RS, et al : Risk of second cancer after treatment for Hodgkin's disease. N Engl J Med 318 : 76-81, 1988 17) Hunger SP, Tkachuk DC, Amylon MD, et al : HRX involvement in de novo and secondary leukemias with diverse chromosome 11 q23 abnormalities. Blood 81 : 3197-3203, 1993 20) Negrini M, Felix CA, Martin C, et al : Potential topoisomerase IIDNA-binding sites at the breakpoints of a t (9; 11) chromosome translocation in acute myeloid leukemia. Cancer Res 53 : 4489-4492, 1993 1) Michels SD, McKenna RW, Arthur DC, et al : Therapy-related acute myeloid leukemia and myelodysplastic syndrome. Blood 65 : 1364-1372, 1985 9) Balis FM, Holcenberg JS, Poplack DG : General principles of chemotherapy. Principles and practice of pediatric oncology. Pizzo PA ed 2nd ed JB Lippincott Company Philadelphia 1993,227-228 15) Coco FL, Mandelli F, Breccia M, et al : Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia. Cancer Res 53 : 3800-3803, 1993 19) Nakamura T, Alder H, Gu Y, et al : Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 90 : 4631-4635, 1993 14) Ford AM, Ridge SA, Cabrera ME, et al : In utero rearrangements in the trithorax-related oncogene in infant leukemias. Nature 363 : 358-360, 1993 11) 生嶋聡, 片岡桂子, 吉原隆夫 : llq23を有する小児白血病の臨床的検討.日小血会誌7 : 413-419, 1993 12) Gu Y, Nakayama T, Alder H, et al : The t (4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to drosophila trithorax, to the AF-4 gene. Cell 71 : 701-708, 1992 3) Whitlock JA, Greer JP, Lukens JN : Epipodophyllotoxin related leukemia. Cancer 68 : 600-604, 1991 |
| References_xml | – reference: 6) Yamamoto K, Seto M, Akao Y, et al : Gene rearrangement and truncated mRNA in cell lines with 11q23 translocation. Oncogene 8 : 479-485, 1993 – reference: 9) Balis FM, Holcenberg JS, Poplack DG : General principles of chemotherapy. Principles and practice of pediatric oncology. Pizzo PA ed 2nd ed JB Lippincott Company Philadelphia 1993,227-228 – reference: 13) van der Poel S, McCabe R, Cill J, et al : Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88 : 10735-10739, 1991 – reference: 15) Coco FL, Mandelli F, Breccia M, et al : Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia. Cancer Res 53 : 3800-3803, 1993 – reference: 5) Henze G, Frengler R, Hartmann R, et al : BFM results in relapsed childhood acute lymphoblastic leukemia. Haematology and blood transfusion Vol 33 Acute leukemia II, Buchner T ed Springer-Verlag Berlin 1990,619-626 – reference: 8) Chak LY, Sikic BI, Tucker MA, et al : Increasedincidence of acute nonlymphocytic leukemia following therapy in patient with small cell carcinoma of the lung. J Clin Oncol 2 : 385-390, 1984 – reference: 1) Michels SD, McKenna RW, Arthur DC, et al : Therapy-related acute myeloid leukemia and myelodysplastic syndrome. Blood 65 : 1364-1372, 1985 – reference: 7) Tucker MA, Coleman CN, Cox RS, et al : Risk of second cancer after treatment for Hodgkin's disease. N Engl J Med 318 : 76-81, 1988 – reference: 19) Nakamura T, Alder H, Gu Y, et al : Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 90 : 4631-4635, 1993 – reference: 17) Hunger SP, Tkachuk DC, Amylon MD, et al : HRX involvement in de novo and secondary leukemias with diverse chromosome 11 q23 abnormalities. Blood 81 : 3197-3203, 1993 – reference: 10) 林泰秀, 稲葉俊哉, 花田良二, 他 : 乳児急性白血病の染色体所見と臨床像.日児誌95 : 2394-2400, 1991 – reference: 18) Corral J, Forster A, Thompson S, et al : Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc Natl Acad Sci USA 90 : 8539-8542, 1993 – reference: 3) Whitlock JA, Greer JP, Lukens JN : Epipodophyllotoxin related leukemia. Cancer 68 : 600-604, 1991 – reference: 20) Negrini M, Felix CA, Martin C, et al : Potential topoisomerase IIDNA-binding sites at the breakpoints of a t (9; 11) chromosome translocation in acute myeloid leukemia. Cancer Res 53 : 4489-4492, 1993 – reference: 2) Pui CH, Ribeiro RG, Hancock ML, et al : Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N Engl J Med 325 : 1682-1687, 1991 – reference: 4) Rivera GK, Buchanan G, Boyett JM, et al : Intensive retreatmant of childhood acute lymphoblastic leukemia in first bone marrow relapse. N Engl J Med 315 : 275-278, 1986 – reference: 11) 生嶋聡, 片岡桂子, 吉原隆夫 : llq23を有する小児白血病の臨床的検討.日小血会誌7 : 413-419, 1993 – reference: 12) Gu Y, Nakayama T, Alder H, et al : The t (4; 11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to drosophila trithorax, to the AF-4 gene. Cell 71 : 701-708, 1992 – reference: 14) Ford AM, Ridge SA, Cabrera ME, et al : In utero rearrangements in the trithorax-related oncogene in infant leukemias. Nature 363 : 358-360, 1993 – reference: 16) Tkachuk DC, Kohler S, Cleary ML : Involvement of a homolog of drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71 : 691-700, 1992 |
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| Title | A Case of Secondary Leukemia Having t (9; 11) and MLL Gene Rearrangement Possibly Due to Etoposide |
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