An Infant of Acute Megakaryoblastic Leukemia with Hypercalcemia and Infiltration to the Lung, Heart and Brain

• Published in: The Japanese Journal of Pediatric Hematology Vol. 8; no. 3; pp. 245 - 249
• Main Authors: KIGASAWA, Hisato, HONDA, Kohjiro, NISHIHIRA, Hirokazu, NAGAO, Takeshi, OGAWA, Shoko, TOYODA, Yasunori, ODA, Takanori
• Format: Journal Article
• Language: Japanese
• Published: THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 1994; 特定非営利活動法人 日本小児血液・がん学会
• Subjects: acute megakaryoblastic leukemia; hypercalcemia; organ involvement
• ISSN: 0913-8706; 1884-4723
• DOI: 10.11412/jjph1987.8.245

We report herein a 4-month-old girl with acute megakaryoblastic leukemia, who presented with hypercalcemia at diagnosis and showed infiltration to the lung, heart and brain. Her serum calcium level was elevated at 16.8 mg/di on admission. Bone X-ray revealed marked osteolytic change of the whole skeleton. Chest roentgenogram and computed tomography revealed diffuse infiltration in the bilateral lung fields, and a mass lesion in the left atrium was shown by echocardiogram. After chemotherapy, serum calcium level normalized quickly. Although brain involvement appeared during the course of treatment, the lesions of organ involvements were improved by more intensive chemotherapy. She is alive 36 months after the onset, and has remained disease-free 16 months after cessation of chemotherapy. Only two cases who were acute megakaryoblastic leukemia with hypercalcemia were reported, while no case with hypercalcemia at the onset was reported. This is the first report of a pediatric case of affected megakaryoblastic leukemia with hypercalcemia. Since her organ involvements were observed with roentgenogram, computed tomography and echocardiogram, without pathological examinations, this case may provide useful information.