Biliary excretion of tauroursodeoxycholate, ICG and BSP in bile duct-ligated rats

• Published in: Tando Vol. 19; no. 1; pp. 28 - 32
• Main Authors: SASAMOTO, Takahiro, TAKAYANAGI, Motoe, SANO, Naoyo, TAKIKAWA, Hajime, AKASHI, Masahiro, MIKAMI, Masaki, TAKAMORI, Yoriyuki, KURIHARA, Hiroko, TANAKA, Atsushi, UEGAKI, Satoko, NAGAMACHI, Yukiko
• Format: Journal Article
• Language: Japanese
• Published: Japan Biliary Association 2005
• Subjects: Bile duct-ligated rat; biliary excretion; BSP; ICG; tauroursodeoxycholate; タウロウルソデオキシコール酸; 胆汁中排泄; 胆管結紮ラット
• ISSN: 0914-0077; 1883-6879
• DOI: 10.11210/tando1987.19.1_28

Various hepatic transporters such as Mrp 2 and Bsep are considered to be down-regulated in obstructive jaundice. In the present study, the biliary transport maximum (Tm) of tauroursodeoxycholate (TUDC), a Bsep substrate, BSP, an Mrp 2 substrate, and ICG was studied in bile ductligated rats for 3 days (BDL rats). In BDL rats, the Tm of TUDC and ICG was decreased to 53%and 40% of controls. The Tm of BSP was markedly decreased in BDL rats (13% of controls), and was relieved to 44% of controls by the coadministration of TUDC. The decrease of the Tm of TUDC was not as prominent as that of taurocholate, probably due to the enhancement of the vesicular targeting of Bsep to the canalicular membrane and the phosphorylation of Bsep, which are specific to TUDC. The recovery of the Tm of BSP by TUDC in BDL rats is considered to be due to the partial recovery of the Mrp 2 function by TUDC.