A Case of CD2, CD19 Positive Acute Lymphoblastic Leukemia

A case of biphenotypic acute lymphoblastic leukemia coexpressing CD2 and CD19 antigens is reported. The patient, a 12-year-old boy, had generalized, remarkable, lymphadenopathy, especially at cervical, axillar, paraaortic, and inguinal regions. The peripheral leukocyte counts were 5, 000/μl with 58....

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Published inThe Japanese Journal of Pediatric Hematology Vol. 6; no. 3; pp. 275 - 279
Main Authors NAYA, Mayumi, IMASHUKU, Shinsaku, KATAOKA, Yoshiko, HIBI, Shigeyoshi, TAKAYA, Kazushi, MORIMOTO, Masahumi
Format Journal Article
LanguageJapanese
Published THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 1992
特定非営利活動法人　日本小児血液・がん学会
Subjects
biphenotypic leukemia
CD19
CD2
急性リンパ性白血病
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ISSN0913-8706
1884-4723
DOI10.11412/jjph1987.6.275

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Summary:A case of biphenotypic acute lymphoblastic leukemia coexpressing CD2 and CD19 antigens is reported. The patient, a 12-year-old boy, had generalized, remarkable, lymphadenopathy, especially at cervical, axillar, paraaortic, and inguinal regions. The peripheral leukocyte counts were 5, 000/μl with 58.0% blasts. Bone marrow was occupied with 97.5% large or small blasts with lymphoid appearance. The surface marker analysis by two-color flowcytometry revealed that the blasts were positive for both CD2 and CD 19 at single cell level. The rearrangement of IgH and TCR-β genes were both detected. After responding to our protocol for high risk group ALL, he has achieved a complete remission and remains free of disease for eighteen months.
ISSN:0913-8706
1884-4723
DOI:10.11412/jjph1987.6.275