Changes of lymphocrte function in obstructive jaundiced states

A clinical and exprimental evaluation on lymphocyte transformation ability under jaundiced state, and the effect of serum obtained from jaundiced subjects were performed, giving the following results. 1) the lymphocyte's transformation ability was proven to be decreased at jaundiced states both...

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Published inTando Vol. 6; no. 1; pp. 45 - 53
Main Authors KATO, Fumihiko, AKAMO, Yoshimi, MURAMOTO, Masayuki, TAKAOKA, Tetsuro, FUKUI, Takuji, SHIBATA, Kiyohito
Format Journal Article
LanguageJapanese
Published Japan Biliary Association 1992
Subjects
リンパ球幼若化反応
リンパ球幼若化反応抑制因子
減黄処置
閉塞性黄疸
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ISSN0914-0077
1883-6879
DOI10.11210/tando1987.6.1_45

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Abstract A clinical and exprimental evaluation on lymphocyte transformation ability under jaundiced state, and the effect of serum obtained from jaundiced subjects were performed, giving the following results. 1) the lymphocyte's transformation ability was proven to be decreased at jaundiced states both clinically and experimentally. 2) The serum obtained from jaundiced subjects, proved to contain an inhibitory substance against lymphocyte transformation. These results indicate that the reduction of the level of hyperbilirubinemia, is of value in terms of improving the patients'immunological strength, especially the lymphocyte's power.
AbstractList A clinical and exprimental evaluation on lymphocyte transformation ability under jaundiced state, and the effect of serum obtained from jaundiced subjects were performed, giving the following results. 1) the lymphocyte's transformation ability was proven to be decreased at jaundiced states both clinically and experimentally. 2) The serum obtained from jaundiced subjects, proved to contain an inhibitory substance against lymphocyte transformation. These results indicate that the reduction of the level of hyperbilirubinemia, is of value in terms of improving the patients'immunological strength, especially the lymphocyte's power. 閉塞性黄疸時のリンパ球幼若化反応について, PTBDを施行した臨床例と総胆管結紮にて作成した閉塞性黄疸モデルにおいて検討を行なうと共に閉塞性黄疸血清のリンパ球機能に対する影響について検討した. その結果 1)閉塞性黄疸時にはリンパ球幼若化反応の低下が臨床的, 実験的に証明された. また臨床例において減黄術による T.B.の正常化に伴いリンパ球幼若化反応の改善が認められた. 2)閉塞性黄疸の血清中にリンパ球幼若化反応に対する抑制因子の存在が実験的に証明された. 以上より閉塞性黄疸時における黄疸軽減処置は患者の免疫能改善において重要な治療法であると考える.
A clinical and exprimental evaluation on lymphocyte transformation ability under jaundiced state, and the effect of serum obtained from jaundiced subjects were performed, giving the following results. 1) the lymphocyte's transformation ability was proven to be decreased at jaundiced states both clinically and experimentally. 2) The serum obtained from jaundiced subjects, proved to contain an inhibitory substance against lymphocyte transformation. These results indicate that the reduction of the level of hyperbilirubinemia, is of value in terms of improving the patients'immunological strength, especially the lymphocyte's power.
Author SHIBATA, Kiyohito
KATO, Fumihiko
AKAMO, Yoshimi
TAKAOKA, Tetsuro
FUKUI, Takuji
MURAMOTO, Masayuki
Author_FL 福井 拓治
村元 雅行
加藤 文彦
赤毛 義実
高岡 哲郎
柴田 清人
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  fullname: SHIBATA, Kiyohito
  organization: Departmnt of Surgery, Tajimi Municipal Hospittal
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DocumentTitleAlternate 臨床的, 実験的閉塞性黄疸時におけるリンパ球機能の変動
DocumentTitle_FL 臨床的, 実験的閉塞性黄疸時におけるリンパ球機能の変動
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References 8) Willems FTC, Melnik JL, Rawls WE: Viral in hibition of the phytohemag glutinin resp onse to human lymphocytes and application to viral hepatitis. Proc Soc Exo Biol 130: 652-661, 1969
10) Raphael MK, Thomas RG, Andrew MM, et al: Impairment of humann lymphocyte function by bile salts. Surgery 95: 439-443, 1984
11) Gianni LF, Dipadova FM, Podda M: Bile Acid-Induced Inhibition of the Lymphoproliferative Response to Phytohemagglutin in and Pokeweed Mitogen: An In Vitro Study. Gastroenterology 78: 231-235, 1980
1) Macsween RNM Thomas MA: Lymphocyte transformation by phytohemagglutini n (PHA)and purified protein derivative (PPD) in primary biliary cirrhosis. Evidence of serum inhibitory factors. Clin Exp Immunol 15: 52 3533, 1973
2) Fox RA, Dudley FJ, Samuels M, et al.: Lymphocyte transformation in reaponse to phy t ohemagglutinin in primary biliary cirrhos is. The search for a plasma inhibitory factor. Gut 14: 89-93, 1973
3) Hsu CCS, Leevy CM: Inhibition of PHA stimulated lymphocyte transformation by plasm a from patients with advanced alcoholic cir rhosis. Clin Exp Immunol 8: 749-760, 1971
6) Brattig N, Berg, PA: Serum inhibitory factors (SIF) in patients with acute and chronic hepatitis and their clinical significance. Clin Exp Im munol 25: 40-49, 1976
9) Agarwal SS, Blumberg BS, Gerstley B JS, et al: Lymphocyte transformation and heptitis. I. Impairment of thymidine incorporation and DNA polymerase activity. Proc Soc Exp Biol Med 137: 1,498-1,502, 1971
5) Wands JR, Perrotto. JL, Alpert E Issebacher, K. J.: Cell-mediated immunity in acute and chronic hepatitis. J Clin Investigation 55: 929, 1975
4) Young GF, Dudley FL von der Weyden MB: Suppressive effect of alcoholic liver disease sera on lymphocyte transformation. Gut 20: 833-839, 1979
7) Newble DI, Hormes KT, Wangel AG, et al: Immune reactions in acute viral hepatits. Clin Exp Immunol 20: 17-28, 1975
References_xml – reference: 9) Agarwal SS, Blumberg BS, Gerstley B JS, et al: Lymphocyte transformation and heptitis. I. Impairment of thymidine incorporation and DNA polymerase activity. Proc Soc Exp Biol Med 137: 1,498-1,502, 1971
– reference: 8) Willems FTC, Melnik JL, Rawls WE: Viral in hibition of the phytohemag glutinin resp onse to human lymphocytes and application to viral hepatitis. Proc Soc Exo Biol 130: 652-661, 1969
– reference: 10) Raphael MK, Thomas RG, Andrew MM, et al: Impairment of humann lymphocyte function by bile salts. Surgery 95: 439-443, 1984
– reference: 11) Gianni LF, Dipadova FM, Podda M: Bile Acid-Induced Inhibition of the Lymphoproliferative Response to Phytohemagglutin in and Pokeweed Mitogen: An In Vitro Study. Gastroenterology 78: 231-235, 1980
– reference: 4) Young GF, Dudley FL von der Weyden MB: Suppressive effect of alcoholic liver disease sera on lymphocyte transformation. Gut 20: 833-839, 1979
– reference: 3) Hsu CCS, Leevy CM: Inhibition of PHA stimulated lymphocyte transformation by plasm a from patients with advanced alcoholic cir rhosis. Clin Exp Immunol 8: 749-760, 1971
– reference: 2) Fox RA, Dudley FJ, Samuels M, et al.: Lymphocyte transformation in reaponse to phy t ohemagglutinin in primary biliary cirrhos is. The search for a plasma inhibitory factor. Gut 14: 89-93, 1973
– reference: 7) Newble DI, Hormes KT, Wangel AG, et al: Immune reactions in acute viral hepatits. Clin Exp Immunol 20: 17-28, 1975
– reference: 6) Brattig N, Berg, PA: Serum inhibitory factors (SIF) in patients with acute and chronic hepatitis and their clinical significance. Clin Exp Im munol 25: 40-49, 1976
– reference: 1) Macsween RNM Thomas MA: Lymphocyte transformation by phytohemagglutini n (PHA)and purified protein derivative (PPD) in primary biliary cirrhosis. Evidence of serum inhibitory factors. Clin Exp Immunol 15: 52 3533, 1973
– reference: 5) Wands JR, Perrotto. JL, Alpert E Issebacher, K. J.: Cell-mediated immunity in acute and chronic hepatitis. J Clin Investigation 55: 929, 1975
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SubjectTerms リンパ球幼若化反応
リンパ球幼若化反応抑制因子
減黄処置
閉塞性黄疸
Title Changes of lymphocrte function in obstructive jaundiced states
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