Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

• Published in: The Journal of nuclear medicine (1978) Vol. 58; no. 7; p. 1124
• Main Authors: Barret, Olivier, Alagille, David, Sanabria, Sandra, Comley, Robert A, Weimer, Robby M, Borroni, Edilio, Mintun, Mark, Seneca, Nicholas, Papin, Caroline, Morley, Thomas, Marek, Ken, Seibyl, John P, Tamagnan, Gilles D, Jennings, Danna
• Format: Journal Article
• Language: English; Japanese
• Published: 01.07.2017

18F-AV-1451 is currently the most widely used of several experimental tau PET tracers. The objective of this study was to evaluate 18F-AV-1451 binding with full kinetic analysis using a metabolite-corrected arterial input function and to compare parameters derived from kinetic analysis with SUV rati...