Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70

• Published in: bioRxiv
• Main Authors: Kemp, Steven A, Meng, Bo, Ferriera, Isabella Atm, Rawlings Datir, Harvey, William T, Papa, Guido, Lytras, Spyros, Collier, Dami A, Ahmed, Mohamed, Gallo, Giulia, Thakur, Nazia, The Covid-19 Genomics Uk (Cog-Uk) Consortium, Carabelli, Alessandro M, Kenyon, Julia C, Lever, Andrew M, De Marco, Anna, Saliba, Christian, Culap, Katja, Cameroni, Elisabetta, Piccoli, Luca, Corti, Davide, James, Leo C, Bailey, Dalan, Robertson, David L, Gupta, Ravindra K
• Format: Paper
• Language: English; Japanese
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 08.03.2021
• Subjects: Amino acids; Cell fusion; Gene deletion; Infectivity; Mutation; S gene; Severe acute respiratory syndrome coronavirus 2; Spike protein; Vaccines; Virions

Abstract SARS-CoV-2 amino acid replacements in the receptor binding domain (RBD) occur relatively frequently and some have a consequence for immune recognition. Here we report recurrent emergence and significant onward transmission of a six-nucleotide out of frame deletion in the S gene, which resul...