The Hypercoagulable State in Hypercholesterolemia

• Published in: The Journal of Japan Atherosclerosis Society Vol. 19; no. 9-10; pp. 829 - 832
• Main Authors: TAMAKI, Shigehisa, SHIRAKAWA, Shigeru, MORI, Yoshitaka, MORITA, Yuji, TAKESHIRO, Akira, OHNO, Yasuo, OHIWA, Michiaki, SAKAGUCHI, Toshihiko, WADA, Hideo, KATAOKA, Yoshitaka, TANIGAWA, Motoaki, DEGUCHI, Katsumi, INOKI, Masayuki
• Format: Journal Article
• Language: Japanese
• Published: Japan Atherosclerosis Society 01.10.1991
• Subjects: fibrinopeptide A; hypercholesterolemia; lipoprotein (a); plasminogen activator inhibitor-1; thrombin-antithrombin III complex
• ISSN: 0386-2682; 2185-8284
• DOI: 10.5551/jat1973.19.9-10_829

Hypercholesterolemia is associated with the increased incidence of vascular complications. In order to assess the actual degree of activation of the coagulation and fibrinolytic systems in hypercholesterolemia, the plasma levels of fibrinopeptide A (EPA), thrombin-antithrombin III complex (TAT), plasmin α2-plasmin inhibitor complex (PIC), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAT-1) were measured in 32 patients with hypercholesterolemia. All the patients were evaluated in a mass examination and the levels of their serum cholesterol were above 300mg/dl. The mean plasma levels of FPA (mean value±SD:8.26±9.46ng/ml), TAT (8.82±12.23ng/ml), and PAI-1 (148±111ng/ml) were significantly elevated in the patients with hypercholesterolemia compared to healthy subjects. Recently, lipoprotein (a) (Lp (a)) has been reported as a risk factor of atherosclerosis and myocardial infarction. TAT was significantly higher in the group with more than 15mg/dl of Lp (a) concentration than in the group with less than 15mg/dl (p<0.05). These findings indicate a hypercoagulable state in hypercholesterolemia and the possibility that it is a risk factor of thrombosis complications in hypercholesterolemia with high levels of TAT and PAT-1.