Upregulation of PD-L1 Expression by Prostaglandin E 2 and the Enhancement of IFN-γ by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection

• Published in: Frontiers in veterinary science Vol. 7; p. 12
• Main Authors: Goto, Shinya, Konnai, Satoru, Hirano, Yuki, Kohara, Junko, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Minato, Erina, Kobayashi, Atsuhi, Gondaira, Satoshi, Higuchi, Hidetoshi, Koiwa, Masateru, Tajima, Motoshi, Taguchi, Eiji, Uemura, Ryoko, Yamada, Shinji, Kaneko, Mika K, Kato, Yukinari, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Switzerland 01.02.2020
• Subjects: immunoinhibitory molecules; immune dysfunction; T-cell exhaustion; prostaglandin E2; PD-L1; cattle; Mycoplasma bovis; PD-1

Bovine mycoplasmosis caused by results in pneumonia and mastitis in cattle. We previously demonstrated that the programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) pathway is involved in immune dysfunction during infection and that prostaglandin E (PGE ) suppressed immune responses and upregulated PD-L1 e...