In vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer

• Published in: NMR in biomedicine Vol. 32; no. 10
• Main Authors: Rothman, Douglas L., Graaf, Robin A., Hyder, Fahmeed, Mason, Graeme F., Behar, Kevin L., De Feyter, Henk M.
• Format: Journal Article
• Language: English; Japanese
• Published: Oxford Wiley Subscription Services, Inc 01.10.2019
• Subjects: Biological products; Brain; Brain cancer; Cancer; Cycles; Energy costs; In vivo methods and tests; Mental disorders; Neurotransmission; Neurotransmitters; Spatial resolution

In the last 25 years 13C MRS has been established as the only noninvasive method for measuring glutamate neurotransmission and cell specific neuroenergetics. Although technically and experimentally challenging 13C MRS has already provided important new information on the relationship between neuroen...