Fibrinolytis activity in the patients with renal diseases

• Published in: The Japanese Journal of Nephrology Vol. 18; no. 12; pp. 793 - 801
• Main Authors: Taura, Koichi, Shinzato, Ken, Harada, Takashi, Ogata, Hirofumi, Fujimatsu, Shinichiro, Kinoshita, Masaru, Horita, Satoru, Fujiwara, Tsuneo, Hara, Kohei, Fujita, Senji, Itoga, Takashi, Shindo, Kazuhiko, Kondo, Atsushi, Tadaharu, Sho, Matsukuma, Genichiro, Funakoshi, Eiichi
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Nephrology 31.12.1976
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.18.793

The blood fibrinolytic activity was examined in 51 patients with renal diseases by means of lysine-sepharose-affinity chromatography and fibrin-agar-plate. The subjects consisted of 11 cases of chronic glomerulonephritis, 11 cases of chronic renal failure, 16 cases of nephrotic syndrome and 13 cases in maintenance haemodialysis. The results were as follows.1. Mean plasma fibrinogen level was 412mg/dl in the patients with chronic renal failure being significantly higher than 267mg/dl in the patients with chronic glomerulonephritis. In the patients with nephrotic syndrome, a high level (443mg/dl) was revealed jn the group before treatment, but a low level (304mg/dl) after treatment. In these cases, a significant correlation was recognized between serum total protein and plasma fibrinogen levels. Most patients in haemodialysis were within normal range.2. The level of serum fibrin or fibrinogen degradation products (FDP) was mostly in normal range, but slightly elevated in one case each of chronic renal failure and nephrotic syndrome and two cases of haemodialysis, totalling four cases.3. Euglobulin clot lysis time (FLT) was normal in patients with nephrotic syndrome, but ranged from 3 to 13 hours in the group of haemodialysis. It was more prolonged in chronic renal failure than in chronic glomerulonephritis.4. Plasma plasminogen showed a low level in 6 of 13 patients in maintenance hsemodialysis, but was within normal limit in other groups.5. Antiplasmin activity increased in 5 of 11 patients with chronic glomerulonephritis, 5 of 11 patients with chronic renal failure and 5 of 16 paticnts with neprotic syndrome, but decreased in 5 of 13 patients in haemodialysis.6. Serum a2-macroglobulin showed a nigh level in approximately one third of cases with chronic glomerulonephritis and nephrotic syndrome. On the contrary it indicated a low level in about half of chronic renal failure and haemodialysis. However, serum a1-antitrypsin increased in two-thirds of cases with chronic glomerulonephritis and chronic renal failure. In nephrotic syndrome, the value decreased remarkably after treatment.