Urinary Prostaglandin E in Patients with Hypertension Relationship to R, enin-Angiotensin-Aldosterone System
The interrelationship between Renin-Angiotensin-Aldosterone (R-A-A) system and renal prosta-glandin E (PGE) was studied in essential hypertension and primary aldosteronism. Urinary PGE, converted to PGB before extraction, was measured by radioimmunoassay using PGE antiserum. The accuracy and reprodu...
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| Published in | The Japanese Journal of Nephrology Vol. 22; no. 6; pp. 739 - 751 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Nephrology
1980
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| Online Access | Get full text |
| ISSN | 0385-2385 1884-0728 |
| DOI | 10.14842/jpnjnephrol1959.22.739 |
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| Abstract | The interrelationship between Renin-Angiotensin-Aldosterone (R-A-A) system and renal prosta-glandin E (PGE) was studied in essential hypertension and primary aldosteronism. Urinary PGE, converted to PGB before extraction, was measured by radioimmunoassay using PGE antiserum. The accuracy and reproducibility of this method was excellent enough to determine the level of urinary PGE. Urinary excretion of PGE was significantly decreased in patients with essential hypertension and primary aldosteronism compared with that of normal subjects. In essential hypertension and normal subjects, there was no significant correlation between plasma reamn activity (PRA) and urinary excretion of PGE but a significant positive correlation was found between urinary excretion of sodium and that of PGE. Urinary excretion of PGE was not decreased in low renin essential hyper-tension. No obvious relationship was observed between the changes in PRA and urinary excretion of PGE during the stimulation of renin release. After the restriction of sodium intake urinary ex-cretion of PGE was significantly decreased in spite of the marked increase in PRA and plasma aldo-sterone concentration (PAC). These data does not support that R-A-A system is the main regu-lator of renal PGE synthesis. It was suggested that renal PGE may play a role in renal sodium handling. In primary aldosteronism, aldosterone antagonist which reduced the urinary excretion of kallikreinn in our previous experiment did not decrease the urinary excretion of PGE, suggesting no direct relationship between renal kallikrein-kinin system and renal PGE synthesis in man. Thus, aldo sterone may not stimulate the renal PGE synthesis, though it activates the renal kallikrein-kinin system. In essential hypertension, R-A-A system was activated by the administration of furosemide and low sodium diet. The addition of indomethacin significantly decreased the urinary excretion of PGE and reduced the enhanced PRA and PAC to control level. It was suggested that the renal prostaa glandins play an imporsant role in renin release. |
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| AbstractList | The interrelationship between Renin-Angiotensin-Aldosterone (R-A-A) system and renal prosta-glandin E (PGE) was studied in essential hypertension and primary aldosteronism. Urinary PGE, converted to PGB before extraction, was measured by radioimmunoassay using PGE antiserum. The accuracy and reproducibility of this method was excellent enough to determine the level of urinary PGE. Urinary excretion of PGE was significantly decreased in patients with essential hypertension and primary aldosteronism compared with that of normal subjects. In essential hypertension and normal subjects, there was no significant correlation between plasma reamn activity (PRA) and urinary excretion of PGE but a significant positive correlation was found between urinary excretion of sodium and that of PGE. Urinary excretion of PGE was not decreased in low renin essential hyper-tension. No obvious relationship was observed between the changes in PRA and urinary excretion of PGE during the stimulation of renin release. After the restriction of sodium intake urinary ex-cretion of PGE was significantly decreased in spite of the marked increase in PRA and plasma aldo-sterone concentration (PAC). These data does not support that R-A-A system is the main regu-lator of renal PGE synthesis. It was suggested that renal PGE may play a role in renal sodium handling. In primary aldosteronism, aldosterone antagonist which reduced the urinary excretion of kallikreinn in our previous experiment did not decrease the urinary excretion of PGE, suggesting no direct relationship between renal kallikrein-kinin system and renal PGE synthesis in man. Thus, aldo sterone may not stimulate the renal PGE synthesis, though it activates the renal kallikrein-kinin system. In essential hypertension, R-A-A system was activated by the administration of furosemide and low sodium diet. The addition of indomethacin significantly decreased the urinary excretion of PGE and reduced the enhanced PRA and PAC to control level. It was suggested that the renal prostaa glandins play an imporsant role in renin release. |
| Author | Yoshinaga, K. Yasujima, M. Sate, M. Irokawa, N. Abe, K. Otsuka, Y. Haruyama, T. Chiba, Satoru Ito, T. Sakurai, Y. |
| Author_xml | – sequence: 1 fullname: Yasujima, M. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Yoshinaga, K. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Sate, M. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Abe, K. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Sakurai, Y. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Irokawa, N. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Chiba, Satoru organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Ito, T. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Otsuka, Y. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine – sequence: 1 fullname: Haruyama, T. organization: The Second Department of Internal Medicine , Tohoku University School of Medicine |
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| References | 20) Seino, M., Abe, K., Sakurai, Y., Irokawa, N., Yasujima, M., Chiba, S., Otsuka, Y. and Yoshi-naga, K.: Effect of spironolactone on urinary kallikrein excretion in patients with essential hypertension and in primary aldosteronism. Tohoku J. exp. Med., 121: 111-119, 1977. 9) 阿部圭志,大塚庸一,斉藤鉄男,陳文軒,青柳春樹,宮崎青爾,色川伸夫,清野正英,三浦幸雄,小野磐夫,薬袋興児,小林清,関敏克,佐藤辰男,吉永馨:AngiotensinIのRadioimmunoassayによる血漿Renin活性の測定法-aHaber法の改良法,Jap.Circ.J.,36:741-749,1972 19) Kaizu, T. and Margolius, H. S.: Studies on rat renal cortical cell kallikrein I. Separation and measurement. Biochem. Biophys. Acta, 411: 305-315, 1975. 30) Gerber, J. G., Branch, R. A., Nies, A. S., Gerkens, J. F., Shand, D. G., Hollifield, V. and Oates, J. A.: Prostaglandins and renin release : II. Assessment of renin secretion following infusion of PGI2, E2, and D2 into the renal artery of anesthetized dogs Prostaglandins, 15: 81 88, 1978. 21) McGiff, J. C., Itskovitz, H. D., Terragno, A. and Wong, P. Y-K.: Modulation and mediation of the action of the renal kallikrein-kinin system by prostaglandins. Fed. Proc., 35: 175-180, 1976. 12) Frolich, J. C., Williams, W. M., Sweetman, B. J., Smigel, M., Carr, K., Hollifleld, J. W., Fleisher, S., Nies, A. S., Frisk-Holmberg, M. and Oates, J. A.: Analysis of renal prosta-glandin synthesis by competitive protein bind-ing assay and Gas Chromatography-Mass Spec-trometry, In Samuelsson, B. and Paoletti, R (Eds.), Advance in prostaglandin and throm-boxane research Vol. 1. New York: Raven Press, 1976. p. 65-80. 2) McGiff, J. C., Crowshaw, K. and Itskovits, H. D.: Prostaglandins and renal function. Fed. Proc., 33: 39-47, 1974. 25) Terashima, R., Anderson, F. L. and Jubiz, W.: Prostaglandin E release in the dog ; Effect of sodium. Am. J. Physiol. 231: 1429-1432, 1976. 13) Bowden, R. E., Ware, J. H., DeMets, D. L. and Keiser, H. R.: Urinary excretion of immuno-reactive prostaglandin E; A circadian rhythm and the effect of posture. Prostaglandins, 14; 151-161, 1977. 7) Zusman, R. M.: Quantitative conversion of PGA or PGE to PGB. Prostaglandins, 1: 167-168, 1972. 26) Norby, L. H., Weidig, J., Ramwell, P., Slot-koff, L, and Flamenbaum, W.: Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninemic hypoaldostero-nism. Lancet, II, 1118-1121, 1978. 1) Vane, J. R, and McGiff, J. C.: Possible con-tributions of endogenous prostaglandins to the control of blood pressure. Circ. Res., 36-37 suppl. I: I-68-I-75, 1975. 11) Williams, W. M., Frolich, J. C., Nies, A. S. and Oates, J. A.: Urinary prostaglandins : Site of entry into renal tubular fluid. Kidney Int. 11: 256-260, 1977. 4) Weber, P. C., Larsson, C., Anggard, E., Hamberg. M., Corey, E. J., Nicolau, K. C. and Samuelsson, B.: Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circ. Res., 39: 868-874, 1976. 23) Satoh, S. and Zimmerman, B. G.: Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. Circ. Res., 36 -32 suppl. I : I-89---J 96, 1975. 27) Vinci, J. M., Gill, J. R. Jr., Bowden, R. E., Pisano, J. J., Izzo, J. L. Jr., Radfar, N., Taylor` A. A., Zusman, R. M., Bartter, F. C. and Keiser,H. R.: The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition. J. Clin. Invest., 61: 1671-1682, 1978. 14) Tan, S. Y., Sweet, P. and Mulrow, P, J,: Impaired renal production of prostaglandin E2; A mewly identified lesion in human essential hypertension. Prostaglandins, 15: 139 -150,1978. 3) Margolius, H. S., Horwitz, D., Pisano, J. J. and Keiser, H. R.: Relationships among urinary kallikrein, mineralocorticoids and human hyper-tensive disease. Fed. Proc., 35: 203-206, 1976. 15) Papanicolaou, N., Mountkalakis, Th., Safar,M., Bariety, J. and Milliez, P.: Defficiency inrenomedullary prostaglandin synthesis relatedto the evolution of essential hypertension. Ex-perientia, 32: 1015-1017, 1976. 16) McGiff, J.C., Crowshaw, K., Terragno, N . A. and Lonigro, A. J.: Release of a prostaglandin-like substance into renal venous blood in res-ponse to angiotensin II. Circ. Res., 26-27 suppl. I: I-121-I-130, 1970. 6) 色川伸夫,阿部圭志,青柳春樹,保嶋実,目々沢秀俊,宮崎青爾,清野正英,日下隆,伊藤徹9佐藤幸子,小野磐夫,斉藤鉄男,大塚庸一,吉永馨本態性高血圧症の血漿Renin活性についてs日本腎臓学会誌,15:949-960,1973 17) McGiff, J.C., Terragno, N.A., Malik, K.U. and Lonigro, A. J.: Release of a prostaglandin E-like substance from canine kidney by brandy-kinin; Comparison with eledoisin. Circ. Res., 31: 36-43. 1972. 22) Nasjletti, A., McGiff, J. C. and Colina-Chourio, J.: Interrelations of the renal kallikrein-kinin system and renal prostaglandins in the cons-cious rat ; Influence of mineralocorticoids. Circ. Res., 43: 799-807, 1978. 10) Lee, J. B., Covino, B. G., Takman, B. H. and Smith, E. R.: Renomedullary vasodepressor substance, Medullin : Isolation, chemical cha-racterization and physiological properties. Circ. Res., 17: 57-77, 1965. 28) McGiff, J. C. and Wong, P. Y-K.: Compart-mentalization of prostaglandins and prostacy-clin within the kidney; Implications for renal function. Fed. Proc., 38: 89-93, 1979. 29) Whorton, A. R., Smigel, M., Oates, J. A. and. Frölich, J. C.: Regional differences in prosta-cyclin formation by the kidney; Prostacyclin is a major prostaglandin of renal cortex. Bio-chem. Biophys. Acta, 529: 176-180, 1978. 5) Frolich, J, C., Wilson, T. W., Sweetman, B. J., Smigel, M., Nies, A.S., Carr, K., Watson, J.T. and Oates, J. A.: Urinary prostaglandins. Identification and origin. J. Clin. Invest., 55: 763-770, 1975. 24) Stokes, J. and Kokko, J. P.: Inhibition of sodium transport by prostglandin E2 across the isolated, perfused rabbit collecting tubule. J. Clin. Invest., 59: 1099-1104, 1977. 18) Zusman, R. M. and Kelser, ri. x.: rrosta-glandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture ; Stimulation by angiotensin II, bradykinin, and arginine vasopressin. J. Clin. Invest., 60: 215-223, 1977. 8) Auletta, F. J., Zusman, R. M. and Caldwell,B. V.: Development and standardization of radioimmunoassays for prostaglandins E, F and A. Olin. Chem., 20: 1580-1587, 1974. |
| References_xml | – reference: 14) Tan, S. Y., Sweet, P. and Mulrow, P, J,: Impaired renal production of prostaglandin E2; A mewly identified lesion in human essential hypertension. Prostaglandins, 15: 139 -150,1978. – reference: 11) Williams, W. M., Frolich, J. C., Nies, A. S. and Oates, J. A.: Urinary prostaglandins : Site of entry into renal tubular fluid. Kidney Int. 11: 256-260, 1977. – reference: 19) Kaizu, T. and Margolius, H. S.: Studies on rat renal cortical cell kallikrein I. Separation and measurement. Biochem. Biophys. Acta, 411: 305-315, 1975. – reference: 17) McGiff, J.C., Terragno, N.A., Malik, K.U. and Lonigro, A. J.: Release of a prostaglandin E-like substance from canine kidney by brandy-kinin; Comparison with eledoisin. Circ. Res., 31: 36-43. 1972. – reference: 21) McGiff, J. C., Itskovitz, H. D., Terragno, A. and Wong, P. Y-K.: Modulation and mediation of the action of the renal kallikrein-kinin system by prostaglandins. Fed. Proc., 35: 175-180, 1976. – reference: 6) 色川伸夫,阿部圭志,青柳春樹,保嶋実,目々沢秀俊,宮崎青爾,清野正英,日下隆,伊藤徹9佐藤幸子,小野磐夫,斉藤鉄男,大塚庸一,吉永馨本態性高血圧症の血漿Renin活性についてs日本腎臓学会誌,15:949-960,1973。 – reference: 24) Stokes, J. and Kokko, J. P.: Inhibition of sodium transport by prostglandin E2 across the isolated, perfused rabbit collecting tubule. J. Clin. Invest., 59: 1099-1104, 1977. – reference: 10) Lee, J. B., Covino, B. G., Takman, B. H. and Smith, E. R.: Renomedullary vasodepressor substance, Medullin : Isolation, chemical cha-racterization and physiological properties. Circ. Res., 17: 57-77, 1965. – reference: 28) McGiff, J. C. and Wong, P. Y-K.: Compart-mentalization of prostaglandins and prostacy-clin within the kidney; Implications for renal function. Fed. Proc., 38: 89-93, 1979. – reference: 8) Auletta, F. J., Zusman, R. M. and Caldwell,B. V.: Development and standardization of radioimmunoassays for prostaglandins E, F and A. Olin. Chem., 20: 1580-1587, 1974. – reference: 12) Frolich, J. C., Williams, W. M., Sweetman, B. J., Smigel, M., Carr, K., Hollifleld, J. W., Fleisher, S., Nies, A. S., Frisk-Holmberg, M. and Oates, J. A.: Analysis of renal prosta-glandin synthesis by competitive protein bind-ing assay and Gas Chromatography-Mass Spec-trometry, In Samuelsson, B. and Paoletti, R (Eds.), Advance in prostaglandin and throm-boxane research Vol. 1. New York: Raven Press, 1976. p. 65-80. – reference: 30) Gerber, J. G., Branch, R. A., Nies, A. S., Gerkens, J. F., Shand, D. G., Hollifield, V. and Oates, J. A.: Prostaglandins and renin release : II. Assessment of renin secretion following infusion of PGI2, E2, and D2 into the renal artery of anesthetized dogs Prostaglandins, 15: 81 88, 1978. – reference: 2) McGiff, J. C., Crowshaw, K. and Itskovits, H. D.: Prostaglandins and renal function. Fed. Proc., 33: 39-47, 1974. – reference: 20) Seino, M., Abe, K., Sakurai, Y., Irokawa, N., Yasujima, M., Chiba, S., Otsuka, Y. and Yoshi-naga, K.: Effect of spironolactone on urinary kallikrein excretion in patients with essential hypertension and in primary aldosteronism. Tohoku J. exp. Med., 121: 111-119, 1977. – reference: 3) Margolius, H. S., Horwitz, D., Pisano, J. J. and Keiser, H. R.: Relationships among urinary kallikrein, mineralocorticoids and human hyper-tensive disease. Fed. Proc., 35: 203-206, 1976. – reference: 29) Whorton, A. R., Smigel, M., Oates, J. A. and. Frölich, J. C.: Regional differences in prosta-cyclin formation by the kidney; Prostacyclin is a major prostaglandin of renal cortex. Bio-chem. Biophys. Acta, 529: 176-180, 1978. – reference: 7) Zusman, R. M.: Quantitative conversion of PGA or PGE to PGB. Prostaglandins, 1: 167-168, 1972. – reference: 18) Zusman, R. M. and Kelser, ri. x.: rrosta-glandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture ; Stimulation by angiotensin II, bradykinin, and arginine vasopressin. J. Clin. Invest., 60: 215-223, 1977. – reference: 26) Norby, L. H., Weidig, J., Ramwell, P., Slot-koff, L, and Flamenbaum, W.: Possible role for impaired renal prostaglandin production in pathogenesis of hyporeninemic hypoaldostero-nism. Lancet, II, 1118-1121, 1978. – reference: 23) Satoh, S. and Zimmerman, B. G.: Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature. Circ. Res., 36 -32 suppl. I : I-89---J 96, 1975. – reference: 13) Bowden, R. E., Ware, J. H., DeMets, D. L. and Keiser, H. R.: Urinary excretion of immuno-reactive prostaglandin E; A circadian rhythm and the effect of posture. Prostaglandins, 14; 151-161, 1977. – reference: 1) Vane, J. R, and McGiff, J. C.: Possible con-tributions of endogenous prostaglandins to the control of blood pressure. Circ. Res., 36-37 suppl. I: I-68-I-75, 1975. – reference: 16) McGiff, J.C., Crowshaw, K., Terragno, N . A. and Lonigro, A. J.: Release of a prostaglandin-like substance into renal venous blood in res-ponse to angiotensin II. Circ. Res., 26-27 suppl. I: I-121-I-130, 1970. – reference: 5) Frolich, J, C., Wilson, T. W., Sweetman, B. J., Smigel, M., Nies, A.S., Carr, K., Watson, J.T. and Oates, J. A.: Urinary prostaglandins. Identification and origin. J. Clin. Invest., 55: 763-770, 1975. – reference: 15) Papanicolaou, N., Mountkalakis, Th., Safar,M., Bariety, J. and Milliez, P.: Defficiency inrenomedullary prostaglandin synthesis relatedto the evolution of essential hypertension. Ex-perientia, 32: 1015-1017, 1976. – reference: 22) Nasjletti, A., McGiff, J. C. and Colina-Chourio, J.: Interrelations of the renal kallikrein-kinin system and renal prostaglandins in the cons-cious rat ; Influence of mineralocorticoids. Circ. Res., 43: 799-807, 1978. – reference: 9) 阿部圭志,大塚庸一,斉藤鉄男,陳文軒,青柳春樹,宮崎青爾,色川伸夫,清野正英,三浦幸雄,小野磐夫,薬袋興児,小林清,関敏克,佐藤辰男,吉永馨:AngiotensinIのRadioimmunoassayによる血漿Renin活性の測定法-aHaber法の改良法,Jap.Circ.J.,36:741-749,1972 – reference: 25) Terashima, R., Anderson, F. L. and Jubiz, W.: Prostaglandin E release in the dog ; Effect of sodium. Am. J. Physiol. 231: 1429-1432, 1976. – reference: 4) Weber, P. C., Larsson, C., Anggard, E., Hamberg. M., Corey, E. J., Nicolau, K. C. and Samuelsson, B.: Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circ. Res., 39: 868-874, 1976. – reference: 27) Vinci, J. M., Gill, J. R. Jr., Bowden, R. E., Pisano, J. J., Izzo, J. L. Jr., Radfar, N., Taylor` A. A., Zusman, R. M., Bartter, F. C. and Keiser,H. R.: The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition. J. Clin. Invest., 61: 1671-1682, 1978. |
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| Title | Urinary Prostaglandin E in Patients with Hypertension |
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