Metabolism of Adrenocortical Hormone in Patients with Chronic Impaired Renal Function
Metabolism of adrenocortical hormone in patients with chronic impaired renal function was investigated in this study. Urinary 17-OHCS (total, free and fractions-com. F, comp. E, THF, THE) we(re measured by use of thin layer in these 12 patients, including 6 patients who were made to artificial dialy...
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| Published in | The Japanese Journal of Nephrology Vol. 17; no. 9; pp. 823 - 836 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Nephrology
30.09.1975
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| Online Access | Get full text |
| ISSN | 0385-2385 1884-0728 |
| DOI | 10.14842/jpnjnephrol1959.17.823 |
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| Abstract | Metabolism of adrenocortical hormone in patients with chronic impaired renal function was investigated in this study. Urinary 17-OHCS (total, free and fractions-com. F, comp. E, THF, THE) we(re measured by use of thin layer in these 12 patients, including 6 patients who were made to artificial dialysis. Three patients of them were studied on load with ACTH-Z 20 units/day for 3 days intramuscularly and 9 patients were studied on administration of cortisol (1 mg/kg of body weight) intra-venously. Moreover, blood free 11-OHCS was determined in 3 patients with treatment of artificial dialysis. Following results were obtained. 1) The excretion volume of urinary total 17-OHCS remained low coincidently with decrease in creatinine clearance on control, on load with ACTH-Z and on administration of cortisol. 2) In above mentioned patients, the rate of urinary free 17-OHCS to total 17-OHCS exhibited various values which may be influenced with glomerular and tubular lesion, being compared with certain values of normal control. 3) The fractions of urinary 17-OHCS showed small pattern similar to normal control. 4) The excretion pattern of urinary 17-OHCS fractions shifted to cortisol pathway from cortisone pathway on load with ACTH-Z as normal control. 5) In the group with non-hyper BUN, the changes of the excretion volume of urinary 17-OHCS was seemed to be similar to normal control in every 2 hours measurement on administration of cortisol, while in the group with hyper BUN, the changes was not observed. 6) In the patients with artificial dialysis free 11-OHCS remained within normal range but showed abnormal in diurnary variation. |
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| AbstractList | Metabolism of adrenocortical hormone in patients with chronic impaired renal function was investigated in this study. Urinary 17-OHCS (total, free and fractions-com. F, comp. E, THF, THE) we(re measured by use of thin layer in these 12 patients, including 6 patients who were made to artificial dialysis. Three patients of them were studied on load with ACTH-Z 20 units/day for 3 days intramuscularly and 9 patients were studied on administration of cortisol (1 mg/kg of body weight) intra-venously. Moreover, blood free 11-OHCS was determined in 3 patients with treatment of artificial dialysis. Following results were obtained. 1) The excretion volume of urinary total 17-OHCS remained low coincidently with decrease in creatinine clearance on control, on load with ACTH-Z and on administration of cortisol. 2) In above mentioned patients, the rate of urinary free 17-OHCS to total 17-OHCS exhibited various values which may be influenced with glomerular and tubular lesion, being compared with certain values of normal control. 3) The fractions of urinary 17-OHCS showed small pattern similar to normal control. 4) The excretion pattern of urinary 17-OHCS fractions shifted to cortisol pathway from cortisone pathway on load with ACTH-Z as normal control. 5) In the group with non-hyper BUN, the changes of the excretion volume of urinary 17-OHCS was seemed to be similar to normal control in every 2 hours measurement on administration of cortisol, while in the group with hyper BUN, the changes was not observed. 6) In the patients with artificial dialysis free 11-OHCS remained within normal range but showed abnormal in diurnary variation. |
| Author | Kudou, Shigenobu Aoki, Keiji Onodera, Takao Sugawara, Shigeru Mikuni, Tsuneyasu Hirayama, Nobuaki Funyu, Tomihisa Ohno, Kazumi Hitomi, Hiroshi Suzuki, Tadashi Terayama, Yuriko Nigawara, Kazuo |
| Author_xml | – sequence: 1 fullname: Terayama, Yuriko organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Mikuni, Tsuneyasu organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Hirayama, Nobuaki organization: Ohyohkyo Kidney Research Institute, Hirosaki, Jpan – sequence: 1 fullname: Onodera, Takao organization: Ohyohkyo Kidney Research Institute, Hirosaki, Jpan – sequence: 1 fullname: Suzuki, Tadashi organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Nigawara, Kazuo organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Sugawara, Shigeru organization: Ohyohkyo Kidney Research Institute, Hirosaki, Jpan – sequence: 1 fullname: Funyu, Tomihisa organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Ohno, Kazumi organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Aoki, Keiji organization: Ohyohkyo Kidney Research Institute, Hirosaki, Jpan – sequence: 1 fullname: Kudou, Shigenobu organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan – sequence: 1 fullname: Hitomi, Hiroshi organization: Department of Urology, Faculty of Medicine, Hirosaki University, Hirosaki, Japan |
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| References | 32) Deck, K. A.: Das Verhalten der 11-Hydroxy-corticoide im plasma wahrend der extracorporalen Hamodialyse. Klin. Wshr., 45 : 1006, 1967. 8) 臼井敏明,河本裕子,島雄周平,桜井克彦:臨床検査室における血清11-Hydlxycortlccsteroids(11-OHCS)測定。ホと臨床,18:151-155,1970. 11) Reisert, P. M, Weidekkam, B., Scheler, F. and Henning, V.: Die Function der Nebemierenrinde bei Patienten mit chronischer Niereninsuffizienz, VERHOL. DTSCH. GESELLSCH. INN. MED., 74 : 454-457, 1968. 15) 工藤茂宣,寺山百合子,田村瑞穂,二川原和男,白岩康夫,舟生富寿:手術侵襲前後の尿中17-OHCS分画の変動,ホと臨床,20:149-156,1972. 14) 工藤茂宣:手術侵襲時における副腎皮質ホルモンの代謝。日内分泌会誌,47:532-548,1971 25) Karl, H. J.: Die 17-Hydroxycorticcsteroide bei Patienten mit Nierenerkrankungen. Klin. Wschr. 38 : 110-117, 1960. 16) Kudoh, S., Funyu, T., Shiraiwa, Y., Tamura, M., Terayama, Y., and Nigawara, K.: Metabolism of Adrerocortical Hormone in Surgical Stress. Tohoku J. exp. Med., 110: 139-148, 1972. 27) 舟生富寿,工藤茂宣,白岩康夫,田村瑞穂,寺山百合子,二川原和男:非ストレス時および手術侵襲時における外因性コルチゾール,コルチゾンの代謝。ホと臨床,20:731-737,1972 21) Kornel, L.: Renal clearance of free and con-jugated 17-hy droxyc : rticostereids in normoten sive and hygertensive subjects. Lancet, Oct. 19, 775-776, 1957. 23) Marks, L. J. & Leaf, A.: The relationship of the renal excretion of adrenal corticoseroids to variations in renal hemodynamics. J. Clin. Invest., 32 : 813-817, 1953. 26) 舟生富寿,工藤茂宣,白岩康夫,田村瑞穂,寺山百合子,二川原和男:外因性副腎皮質ホルモンの手術侵襲時における代謝,手術,26:1227-1234,1972 9) Karl, H. J.: Untersuchungen uber den Plasm-agehalt and die Ausscheidung von 1-Dehydro-17-Hydroxycticosteroiden nach Belastung mit Predonisolon beim Menschen. Kim. Wschr., 37 : 495-500, 1959. 3) 白岩康夫,田村瑞穂,寺田祐子:腎機能障害時の副腎機能。日泌尿会誌,57;497-499,1966 2) Ganis, F, M., Axelrod, L. R. and Miller, L. L. The metabolism of hydrocortisone by kidney tissue in vitro. J. Biol. Chem., 218: 841-848, 1956. 13) Funyu, T., Kudoh, S., Shiraiwa, Y., Terayama, Y., Nigawara, K. and Hitomi, H. Changes in Fractions of Urinary Free 17-Hydroxycorticosteroids before and after Operation. Tohcku J. exp. Med., 111 : 61-69, 1973. 24) Scurry, M. T. & Shear, L.: Stop-flow analysis cf the reabsorption of cortisol. Endocrinology, 84 : 681-682, 1969. 17) Copinschi, G., Leclercq, P., Cornil, A. and Franckson, J. R. M.: Absence of relationship between induced changes in urine volume and cortisol secretion rate. Acta Endorrinol., 56 93-98, 1967. 29) Brown, H. & Englert, E.: Metabolisn of the conjugated 17-Hydroxycorticosteroids. J. Clin. Invest., 34 : 924, 1955. 20) Bongiovanni, A, M & Eberlein, W. R.: Determination, recovery, identification and renal clearance of conjugated adrenal corticoids in human peripheral blood. Proc. Soc. exp. Biol. (N. Y.) 89 : 281-285, 1955. 22) Kornel, L.: Renal clearance of endogenous 17-hydroxycorticcsteroids in hypertension. J. Clin. Endocr., 20 : 1445-1456, 1960. 30) Samuels, L. T., Brown, H., Eik-Nes, K., Tyler, F.H. and Dominguez, O.V.: Extraadrenal factors affecting the levels of 17-hydroxycorti-costeroids in plasma. Ciba Foundation Colloqurion Endocrinology, 11: 208-232, 1957. 10) 田村瑞穂:泌尿器科患者における副腎機能の研究。日内分泌会誌,47:246-262,1971 33) 笹野伸昭,佐藤義雄,金功,斎藤康男:尿毒症性肺炎と副腎皮質変化をめぐって。日本臨床,17:2051-2061,1959. 34) 木村正方:副腎の組織的研究,特に腎疾患との関係について。弘前医学,17:759-765,1666. 18) Schedl, H. P., Chen, P, S., Greene, G. and Redd, D.: The renal clearance of plas eaa cort-isol. J. Clin. Endocr., 19 : 1223-1229, 1959. 31) Englert, E., Brown, H., Willardson, D. G., Wallach, S. and Simons, E. L.: Metabolism of free and conjugated 17-hydroxyccrticosteroids in subjects with uremia. J. Clin. Endocr., 18 : 36-48, 1958. 1) Schenider, J. J, and Horstmann, P.M. : Effects of incubating compound E and related steroids with various surviving rat tissues. J. Biol. Chem., 196 : 629-638, 1952. 12) 舟生富寿,工藤茂宣,白岩康夫,寺山百合子,二川原和男:手術侵襲時における尿中遊離型17-OHCS分画の変動。日内分泌会誌,48:432-442,1972. 28) Pekkarinen, A. & Kasanen, A.: Plasmalevel, urinary excretion and clearance of 17-OHCS in renal patients after intravenous cortisol injection Acta Endccrinol., 38 : 13-21, 1961. 7) 臼井敏明,河本裕子:血中11-OHCS測定について。臨床病理,19:337-340,1971. 4) Funyu, T., Shiraiwa, Y., Tamura, M., Nigawara, K. and Terada, Y.: Fractions of urinary 17-OHCS in patients with impaired renal function and hypertension. Tohoku J. exp. Med., 94 : 377-384, 1968. 5) 舟生富寿,田村瑞穂,寺田祐子:薄層,クロマトグラフィーによる尿中17-OHCSの測定。ホと臨床,14:981-988,1966. 6) 寺山百合子,白岩康夫,田村瑞穂,工藤茂宣,新谷洋三,二川原和男,舟生富寿:薄層クロマトグラフィーによる17-OHCS分画測定法(第2報)。ホと臨床,19:489-495,1971. 19) Weichselbaum, T.E., Mendeloff, A. I. Margraf H. W. and Sheppard, M.: Hepatic conjugation and renal clearance of 17-hydroxycorticcsteoids in man. Fed. Proc. 14 : 301-302, 1955. |
| References_xml | – reference: 12) 舟生富寿,工藤茂宣,白岩康夫,寺山百合子,二川原和男:手術侵襲時における尿中遊離型17-OHCS分画の変動。日内分泌会誌,48:432-442,1972. – reference: 15) 工藤茂宣,寺山百合子,田村瑞穂,二川原和男,白岩康夫,舟生富寿:手術侵襲前後の尿中17-OHCS分画の変動,ホと臨床,20:149-156,1972. – reference: 18) Schedl, H. P., Chen, P, S., Greene, G. and Redd, D.: The renal clearance of plas eaa cort-isol. J. Clin. Endocr., 19 : 1223-1229, 1959. – reference: 22) Kornel, L.: Renal clearance of endogenous 17-hydroxycorticcsteroids in hypertension. J. Clin. Endocr., 20 : 1445-1456, 1960. – reference: 27) 舟生富寿,工藤茂宣,白岩康夫,田村瑞穂,寺山百合子,二川原和男:非ストレス時および手術侵襲時における外因性コルチゾール,コルチゾンの代謝。ホと臨床,20:731-737,1972 – reference: 26) 舟生富寿,工藤茂宣,白岩康夫,田村瑞穂,寺山百合子,二川原和男:外因性副腎皮質ホルモンの手術侵襲時における代謝,手術,26:1227-1234,1972 – reference: 2) Ganis, F, M., Axelrod, L. R. and Miller, L. L. The metabolism of hydrocortisone by kidney tissue in vitro. J. Biol. Chem., 218: 841-848, 1956. – reference: 21) Kornel, L.: Renal clearance of free and con-jugated 17-hy droxyc : rticostereids in normoten sive and hygertensive subjects. Lancet, Oct. 19, 775-776, 1957. – reference: 4) Funyu, T., Shiraiwa, Y., Tamura, M., Nigawara, K. and Terada, Y.: Fractions of urinary 17-OHCS in patients with impaired renal function and hypertension. Tohoku J. exp. Med., 94 : 377-384, 1968. – reference: 32) Deck, K. A.: Das Verhalten der 11-Hydroxy-corticoide im plasma wahrend der extracorporalen Hamodialyse. Klin. Wshr., 45 : 1006, 1967. – reference: 33) 笹野伸昭,佐藤義雄,金功,斎藤康男:尿毒症性肺炎と副腎皮質変化をめぐって。日本臨床,17:2051-2061,1959. – reference: 17) Copinschi, G., Leclercq, P., Cornil, A. and Franckson, J. R. M.: Absence of relationship between induced changes in urine volume and cortisol secretion rate. Acta Endorrinol., 56 93-98, 1967. – reference: 11) Reisert, P. M, Weidekkam, B., Scheler, F. and Henning, V.: Die Function der Nebemierenrinde bei Patienten mit chronischer Niereninsuffizienz, VERHOL. DTSCH. GESELLSCH. INN. MED., 74 : 454-457, 1968. – reference: 3) 白岩康夫,田村瑞穂,寺田祐子:腎機能障害時の副腎機能。日泌尿会誌,57;497-499,1966 – reference: 9) Karl, H. J.: Untersuchungen uber den Plasm-agehalt and die Ausscheidung von 1-Dehydro-17-Hydroxycticosteroiden nach Belastung mit Predonisolon beim Menschen. Kim. Wschr., 37 : 495-500, 1959. – reference: 25) Karl, H. J.: Die 17-Hydroxycorticcsteroide bei Patienten mit Nierenerkrankungen. Klin. Wschr. 38 : 110-117, 1960. – reference: 19) Weichselbaum, T.E., Mendeloff, A. I. Margraf H. W. and Sheppard, M.: Hepatic conjugation and renal clearance of 17-hydroxycorticcsteoids in man. Fed. Proc. 14 : 301-302, 1955. – reference: 10) 田村瑞穂:泌尿器科患者における副腎機能の研究。日内分泌会誌,47:246-262,1971 – reference: 6) 寺山百合子,白岩康夫,田村瑞穂,工藤茂宣,新谷洋三,二川原和男,舟生富寿:薄層クロマトグラフィーによる17-OHCS分画測定法(第2報)。ホと臨床,19:489-495,1971. – reference: 30) Samuels, L. T., Brown, H., Eik-Nes, K., Tyler, F.H. and Dominguez, O.V.: Extraadrenal factors affecting the levels of 17-hydroxycorti-costeroids in plasma. Ciba Foundation Colloqurion Endocrinology, 11: 208-232, 1957. – reference: 16) Kudoh, S., Funyu, T., Shiraiwa, Y., Tamura, M., Terayama, Y., and Nigawara, K.: Metabolism of Adrerocortical Hormone in Surgical Stress. Tohoku J. exp. Med., 110: 139-148, 1972. – reference: 23) Marks, L. J. & Leaf, A.: The relationship of the renal excretion of adrenal corticoseroids to variations in renal hemodynamics. J. Clin. Invest., 32 : 813-817, 1953. – reference: 13) Funyu, T., Kudoh, S., Shiraiwa, Y., Terayama, Y., Nigawara, K. and Hitomi, H. Changes in Fractions of Urinary Free 17-Hydroxycorticosteroids before and after Operation. Tohcku J. exp. Med., 111 : 61-69, 1973. – reference: 1) Schenider, J. J, and Horstmann, P.M. : Effects of incubating compound E and related steroids with various surviving rat tissues. J. Biol. Chem., 196 : 629-638, 1952. – reference: 8) 臼井敏明,河本裕子,島雄周平,桜井克彦:臨床検査室における血清11-Hydlxycortlccsteroids(11-OHCS)測定。ホと臨床,18:151-155,1970. – reference: 29) Brown, H. & Englert, E.: Metabolisn of the conjugated 17-Hydroxycorticosteroids. J. Clin. Invest., 34 : 924, 1955. – reference: 7) 臼井敏明,河本裕子:血中11-OHCS測定について。臨床病理,19:337-340,1971. – reference: 31) Englert, E., Brown, H., Willardson, D. G., Wallach, S. and Simons, E. L.: Metabolism of free and conjugated 17-hydroxyccrticosteroids in subjects with uremia. J. Clin. Endocr., 18 : 36-48, 1958. – reference: 5) 舟生富寿,田村瑞穂,寺田祐子:薄層,クロマトグラフィーによる尿中17-OHCSの測定。ホと臨床,14:981-988,1966. – reference: 24) Scurry, M. T. & Shear, L.: Stop-flow analysis cf the reabsorption of cortisol. Endocrinology, 84 : 681-682, 1969. – reference: 34) 木村正方:副腎の組織的研究,特に腎疾患との関係について。弘前医学,17:759-765,1666. – reference: 14) 工藤茂宣:手術侵襲時における副腎皮質ホルモンの代謝。日内分泌会誌,47:532-548,1971 – reference: 28) Pekkarinen, A. & Kasanen, A.: Plasmalevel, urinary excretion and clearance of 17-OHCS in renal patients after intravenous cortisol injection Acta Endccrinol., 38 : 13-21, 1961. – reference: 20) Bongiovanni, A, M & Eberlein, W. R.: Determination, recovery, identification and renal clearance of conjugated adrenal corticoids in human peripheral blood. Proc. Soc. exp. Biol. (N. Y.) 89 : 281-285, 1955. |
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