Studies on the modification of hormones in patients with renal failure and clinical evaluation with reference to carbamylated ACTH and insulin

• Published in: Nihon Jinzo Gakkai shi Vol. 27; no. 11; pp. 1605 - 1609
• Main Authors: ISHIKAWA, KAZUO, HATANAKA, HIROSHI, KAWASAKI, TOMIHIRO, KUBOTA, SHINZO, TAKAGI, KIYOSHI, TANKE, GENYO, OIMOMI, MUNETADA, BABA, SHIGEAKI
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Society of Nephrology 01.11.1985
• Subjects: ACTH; Adrenocorticotropic Hormone - biosynthesis; Carbamates; carbamylation; Chromatography, High Pressure Liquid; Humans; insulin; Insulin - biosynthesis; Kidney Failure, Chronic - metabolism; renal failure

It has been reported that hemoglobin Al (HbAl), which is increased in patients with renal failure, is formed by carbamylation of Hb by cyanic acid derived from urea. Carbamylation is a non:enzymatic and non-specific reaction and may occur at some amino groups of proteins other Hb and peptides. We pr...