CLINICAL STUDIES ON SULTAMICILLIN FINE GRANULES IN THE UROLOGICAL FIELD

• Published in: Japanese journal of antibiotics Vol. 41; no. 12; pp. 2044 - 2058
• Main Authors: ARAKAWA, SOICHI, TAKAGI, SINSUKE, MAEDA, HIROSHI, KA, SHOJIN, SIA, I.C., KAMIDONO, SADAO, HIROOKA, KUHEI, SHIMATANI, NOBORI, INOUE, TAKAAKI, TANAKA, HIROKAZU, YASUMURO, CHOZO, HAMAMI, GAKU, SENGOKU, ATSUSHI, OSHIMA, HIDEO, NAGATA, HITOSHI, IWAMOTO, TAKAHIRO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.12.1988
• Subjects: Administration, Oral; Adult; Aged; Aged, 80 and over; Ampicillin - administration & dosage; Ampicillin - pharmacology; Ampicillin - therapeutic use; Ampicillin Resistance; Bacteria - drug effects; Cystitis - drug therapy; Cystitis - microbiology; Dosage Forms; Drug Evaluation; Drug Therapy, Combination - administration & dosage; Drug Therapy, Combination - pharmacology; Drug Therapy, Combination - therapeutic use; Female; Humans; Male; Middle Aged; Sulbactam - administration & dosage; Sulbactam - pharmacology; Sulbactam - therapeutic use; Urinary Tract Infections - drug therapy; Urinary Tract Infections - microbiology
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.41.2044

Clinical studies of sultamicillin (SBTPC) fine granules, an oral antibiotic with ester linked ampicillin and β-lactamase inhibitor, sulbactam, were performed in acute uncomplicated cystitis and complicated urinary tract infections. 1. SBTPC fine granules were administrated at a dose of 187.5mg 2-3 times daily for 5-7days to 6 patients with acute uncomplicated cystitis. Clinical emcacies as judged according to the criteria of the UTI Committee were excellent in 5 cases and moderate in 1 case with an effectiveness rate of 100%. All of 7 identified bacteria were eradicated by the treatment. 2. SBTPC fine granules were administrated at a dose of 187.5mg or 375mg 3 times daily for 5-7 days to 17 patients with complicated urinary tract infections. Clinical efficacies as judged according to the criteria of the UTI Committee were excellent in 8 cases, moderate in 4 cases and poor in 5 cases with an effectiveness rate of 70.6%. Out of 17 identified bacteria, 14 (82.4%) were eradicated by the treatment. 3. As adverse reactions, glossitis, diarrhea and pharyngeal redness were observed in 1 case out of 31 cases treated with the drug. These symptoms, however, were mild and transient. No abnormal laboratory test values were observed. From the above results, it appears that SBTPC fine granules are useful in the treatment of urinary tract infections.