The Relationship Between Glucose Tolerance and Pancreatic Exocrine or Endocrine Function in Chronic Liver Diseases
Pancreozymin-secretin test and glucose tolerance test were performed in 101 patients with chronic liver diseases. Responses of serum insulin and plasma glucagon to glucose or arginine load were also studied in some cases of them. Mild pancreatic exocrine insufficiency was found in 35% of all subject...
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| Published in | Kanzo Vol. 19; no. 3; pp. 270 - 278 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
25.03.1978
|
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.19.270 |
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| Abstract | Pancreozymin-secretin test and glucose tolerance test were performed in 101 patients with chronic liver diseases. Responses of serum insulin and plasma glucagon to glucose or arginine load were also studied in some cases of them. Mild pancreatic exocrine insufficiency was found in 35% of all subjects, but these cases showed no different glucose tolerance and pancreatic endocrine function from those which healthy controls did. Moderate to severe insufficiency was observed in 11% of non-cirrhotic cases and in 6% of cirrhotic cases, and most of them were alcoholics. In these cases glucose intolerance or pancreatic endocrine insufficiency were more often found than mild exocrine insufficient cases. These results suggest that pancreatic disorder dose not influence on glucose tolerance in all cases with chronic liver diseases, but in non-cirrhotic alcoholics it has important roles. So, in such cases pancreatic exocrine and endocrine function must be studied to determine whether concomitant pancreatic disorder results in glucose intolerance. |
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| AbstractList | Pancreozymin-secretin test and glucose tolerance test were performed in 101 patients with chronic liver diseases. Responses of serum insulin and plasma glucagon to glucose or arginine load were also studied in some cases of them. Mild pancreatic exocrine insufficiency was found in 35% of all subjects, but these cases showed no different glucose tolerance and pancreatic endocrine function from those which healthy controls did. Moderate to severe insufficiency was observed in 11% of non-cirrhotic cases and in 6% of cirrhotic cases, and most of them were alcoholics. In these cases glucose intolerance or pancreatic endocrine insufficiency were more often found than mild exocrine insufficient cases. These results suggest that pancreatic disorder dose not influence on glucose tolerance in all cases with chronic liver diseases, but in non-cirrhotic alcoholics it has important roles. So, in such cases pancreatic exocrine and endocrine function must be studied to determine whether concomitant pancreatic disorder results in glucose intolerance. |
| Author | KATO, Katsumoto TAKEICHI, Masayuki SUZUKI, Toshiyuki HAYAKAWA, Tetsuo YAMAZAKI, Yoshihiro OKUMURA, Nobuyoshi SAKAKIBARA, Akira NAKAMURA, Masao TAKEI, Takeshi |
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| References | 26) Sarles. H.: Chronic calcifying pancreatitis-chronic alcoholic pancreatitis. Gastroenterology, 66: 604, 1974. 19) 渡辺静一:Pancreozymin-secretin testにかんする研究,とくに肝,胆道疾患におけるPancreozyrninsecretin testの成績とその臨床的意義について.日内会誌,62: 1352, 1973. 18) Sun, D.C.H.: Malabsorption studies in cirrhosis of the liver. Arch. Intern. Med., 119: 567, 1967. 27) 庵政志,武藤泰敏:アルコールと糖代謝,とくに大量飲酒者における糖代謝異常を中心として.クリニカ,2: 466, 1975. 2) Kato, K.: Clinical investigation on abnormal glucose tolerance in liver cirrhosis. Gastroenterologia Japonica, 11:31, 1976. 12) 山吹隆寛,木村健一:肝機能障害とステロイド糖尿.糖尿病,6: 21, 1963. 5) 鈴木敏行:慢性膵炎における膵内分泌機能障害“特に,アルギニン経静脈負荷時のグルカゴンおよびインスリン分泌について”.日消誌,73: 1509, 1976. 13) 三辺謙他:臓器相関に関する研究(第2報)肝障害と膵および糖代謝.日内会誌,55: 570, 1966. 21) 広瀬昭一郎:肝硬変における膵障害に関する研究(その2)肝硬変ならびに慢性肝炎における膵外分泌機能について. 23) 奥村信義他:慢性肝疾患時の膵障害に関する臨床的検討,第63回日本消化器病学会総会,1977. 8) Stinson, J.C.: Pancreatic lesions associated with cirrhosis of the liver. Amer. J. clin. Path., 27: 117, 1952. 25) 山田正幸他:アルコール性膵障害.最新医学, 31: 2135, 1976. 11) 大坪守:肝硬変,肝癌屍における膵の組織学的研究.日消誌,62: 1089, 1965. 10) 広瀬昭一郎:肝疾患における膵障害に関する研究(その1)肝硬変における膵外分泌腺の組織学的変化について.日消誌,65: 340, 1968. 14) 川村耕造他:肝障害の進展と膵内分泌異常に関する研究.肝臓,7: 320, 1966. 6) 葛谷信貞他:糖負荷試験における糖尿病診断基準委員会報告;糖尿病の診断に用いるための糖負荷試験の判定基準についての勧告.糖尿病,13:1,1970. 4) 松田精:慢性膵炎の膵内分泌機能.糖尿病,17:345, 1974. 20) 渡辺明治:肝硬変症における膵病態にかんする研究,第1編,肝硬変症の膵外分泌機能について.日消誌,64: 823, 1967. 15) Gross. J.B.: External pancreatic function in parenchylmatous hepatic disease as measured by analysis of duodenal contents before and after stimulation with secretin. Gastroenterology. 16: 151, 1950. 3) 加藤活大他:慢性肝疾患の耐糖能異常に関する臨床的検討.日消誌.74: 1179, 1977. 7) 中野哲他:パンクレオザイミン, セクレチン試験の診断的意義;第一報,判定基準を中心として.日消誌,70: 1343, 1973. 22) 中野哲:膵外分泌機能検査(Pancreozymin secretin試験),膵臓病診断学,名古屋大学医学部膵臓研究グループ編1版,医歯薬出版,東京,1974, p. 162. 9) Sobel, H.J. & Waye, J.D.: Pancreatic changes in various types of cirrhosis in alcoholics. Gastroenterology, 45: 341, 1963. 24) Lehlbach. W.K.: Lebershaden bei chronishen Alkoholismus. Teil III: Bioptishe-Histologishe Ergebnisse. Acta Hepatospl., 14: 9, 1967. 1) Kato, K.: Clinical investigation on glucose tolerance in liver cirrhosis. Nagoya J. Med. sci., 35: 91, 1973. 16) Van Goidsenhoven. C.E.: Pancreatic function in cirrhosis of the liver. Amer. J. Dig. Dis., 8: 160, 1963. 17) Zieve. L. & Mulford, D.: Secretion of pancreatic enzyme. III. Response of patients with cirrhosis to secretin and pancreozymin. Amer. J. Dig. Dis., 12: 303, 1967. |
| References_xml | – reference: 15) Gross. J.B.: External pancreatic function in parenchylmatous hepatic disease as measured by analysis of duodenal contents before and after stimulation with secretin. Gastroenterology. 16: 151, 1950. – reference: 2) Kato, K.: Clinical investigation on abnormal glucose tolerance in liver cirrhosis. Gastroenterologia Japonica, 11:31, 1976. – reference: 25) 山田正幸他:アルコール性膵障害.最新医学, 31: 2135, 1976. – reference: 11) 大坪守:肝硬変,肝癌屍における膵の組織学的研究.日消誌,62: 1089, 1965. – reference: 6) 葛谷信貞他:糖負荷試験における糖尿病診断基準委員会報告;糖尿病の診断に用いるための糖負荷試験の判定基準についての勧告.糖尿病,13:1,1970. – reference: 19) 渡辺静一:Pancreozymin-secretin testにかんする研究,とくに肝,胆道疾患におけるPancreozyrninsecretin testの成績とその臨床的意義について.日内会誌,62: 1352, 1973. – reference: 1) Kato, K.: Clinical investigation on glucose tolerance in liver cirrhosis. Nagoya J. Med. sci., 35: 91, 1973. – reference: 3) 加藤活大他:慢性肝疾患の耐糖能異常に関する臨床的検討.日消誌.74: 1179, 1977. – reference: 7) 中野哲他:パンクレオザイミン, セクレチン試験の診断的意義;第一報,判定基準を中心として.日消誌,70: 1343, 1973. – reference: 24) Lehlbach. W.K.: Lebershaden bei chronishen Alkoholismus. Teil III: Bioptishe-Histologishe Ergebnisse. Acta Hepatospl., 14: 9, 1967. – reference: 14) 川村耕造他:肝障害の進展と膵内分泌異常に関する研究.肝臓,7: 320, 1966. – reference: 21) 広瀬昭一郎:肝硬変における膵障害に関する研究(その2)肝硬変ならびに慢性肝炎における膵外分泌機能について. – reference: 23) 奥村信義他:慢性肝疾患時の膵障害に関する臨床的検討,第63回日本消化器病学会総会,1977. – reference: 13) 三辺謙他:臓器相関に関する研究(第2報)肝障害と膵および糖代謝.日内会誌,55: 570, 1966. – reference: 8) Stinson, J.C.: Pancreatic lesions associated with cirrhosis of the liver. Amer. J. clin. Path., 27: 117, 1952. – reference: 22) 中野哲:膵外分泌機能検査(Pancreozymin secretin試験),膵臓病診断学,名古屋大学医学部膵臓研究グループ編1版,医歯薬出版,東京,1974, p. 162. – reference: 26) Sarles. H.: Chronic calcifying pancreatitis-chronic alcoholic pancreatitis. Gastroenterology, 66: 604, 1974. – reference: 12) 山吹隆寛,木村健一:肝機能障害とステロイド糖尿.糖尿病,6: 21, 1963. – reference: 20) 渡辺明治:肝硬変症における膵病態にかんする研究,第1編,肝硬変症の膵外分泌機能について.日消誌,64: 823, 1967. – reference: 9) Sobel, H.J. & Waye, J.D.: Pancreatic changes in various types of cirrhosis in alcoholics. Gastroenterology, 45: 341, 1963. – reference: 27) 庵政志,武藤泰敏:アルコールと糖代謝,とくに大量飲酒者における糖代謝異常を中心として.クリニカ,2: 466, 1975. – reference: 5) 鈴木敏行:慢性膵炎における膵内分泌機能障害“特に,アルギニン経静脈負荷時のグルカゴンおよびインスリン分泌について”.日消誌,73: 1509, 1976. – reference: 10) 広瀬昭一郎:肝疾患における膵障害に関する研究(その1)肝硬変における膵外分泌腺の組織学的変化について.日消誌,65: 340, 1968. – reference: 18) Sun, D.C.H.: Malabsorption studies in cirrhosis of the liver. Arch. Intern. Med., 119: 567, 1967. – reference: 4) 松田精:慢性膵炎の膵内分泌機能.糖尿病,17:345, 1974. – reference: 17) Zieve. L. & Mulford, D.: Secretion of pancreatic enzyme. III. Response of patients with cirrhosis to secretin and pancreozymin. Amer. J. Dig. Dis., 12: 303, 1967. – reference: 16) Van Goidsenhoven. C.E.: Pancreatic function in cirrhosis of the liver. Amer. J. Dig. Dis., 8: 160, 1963. |
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| Subtitle | Exocrine or Endocrine Function in Chronic Liver Diseases |
| Title | The Relationship Between Glucose Tolerance and Pancreatic |
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