リンパ球のmitogen反応性によるLDL receptor活性の検討 CMG-CoA reductase阻害剤(CS-514)を用いて
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| Published in | 動脈硬化 Vol. 15; no. 8; pp. 1595 - 1599 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本動脈硬化学会
01.02.1988
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| Online Access | Get full text |
| ISSN | 0386-2682 2185-8284 |
| DOI | 10.5551/jat1973.15.8_1595 |
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| Author | 広瀬, 立夫 原, まさ子 法岡, 健一 針谷, 正祥 木谷, 敦 中村, 治雄 川越, 光博 近藤, 和雄 宮島, 恵美子 鈴木, 王洋 池脇, 克則 |
|---|---|
| Author_xml | – sequence: 1 fullname: 池脇, 克則 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 宮島, 恵美子 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 川越, 光博 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 法岡, 健一 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 針谷, 正祥 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 近藤, 和雄 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 広瀬, 立夫 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 木谷, 敦 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 中村, 治雄 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 鈴木, 王洋 organization: 防衛医科大学校第一内科 – sequence: 1 fullname: 原, まさ子 organization: 防衛医科大学校第一内科 |
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| References | 8) 掘部博, 笠置文善, 青木伸雄: 我が国における高脂血症患者の疫学的推定. 原発性高脂血症調査研究班, 昭和60年度研究報告書, pp. 51-56. 4) Goldstein, J. L., Brown, M. S. and Stone, N. J.: Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are alleic. Cell, 12: 629-631 (1977). 6) Cuthbert, J. A. and Lipsky, P. E.: Modulation of human lymphocyte responses by low density lipoproteins (LDL): Enhancement but not immunosuppression is mediated by LDL receptors. Proc. Natl. Acad. Sci. U.S.A., 81: 4539-4543 (1984). 2) 垂井清一郎: 総括報告: 原発性高脂血症調査研究班, 昭和60年度研究報告書, pp. 11-22. 5) 林洋, 内藤周幸, 川村光信, 宮崎滋, 加藤泰一, 木下誠. 松島照彦, 橋本佳明, 渡辺毅, 寺本民生: 高脂血症薬の治療効果とリンパ球LDLレセプター―クリノフィブラートを用いた成績―. 動脈硬化, 12: 303, 308 (1984). 3) Havel, R. L., Eder, H. A. and Bragdon, J. H.: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest., 34: 1345-1353 (1955). 1) Cuthbert, J. A., East, C. A., Bilheimer, D. W. and Lipsky, P. E.: Detection of familial hypercholesterolemia by assaying functional low-densitylipoprotein receptors on lymphocytes. New Eng. J. Med., 314: 879-883 (1986). 7) Tsujita, Y., Kuroda, M., Shimada, Y., Tanzawa, K., Arai, M., Kaneko, I., Tanaka, M., Masuda, H., Tarumi, C., Watanabe, Y. and Fujii, S.: CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. Biochim. Biophys. Acta, 877: 50-60 (1986). |
| References_xml | – reference: 8) 掘部博, 笠置文善, 青木伸雄: 我が国における高脂血症患者の疫学的推定. 原発性高脂血症調査研究班, 昭和60年度研究報告書, pp. 51-56. – reference: 2) 垂井清一郎: 総括報告: 原発性高脂血症調査研究班, 昭和60年度研究報告書, pp. 11-22. – reference: 6) Cuthbert, J. A. and Lipsky, P. E.: Modulation of human lymphocyte responses by low density lipoproteins (LDL): Enhancement but not immunosuppression is mediated by LDL receptors. Proc. Natl. Acad. Sci. U.S.A., 81: 4539-4543 (1984). – reference: 3) Havel, R. L., Eder, H. A. and Bragdon, J. H.: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest., 34: 1345-1353 (1955). – reference: 1) Cuthbert, J. A., East, C. A., Bilheimer, D. W. and Lipsky, P. E.: Detection of familial hypercholesterolemia by assaying functional low-densitylipoprotein receptors on lymphocytes. New Eng. J. Med., 314: 879-883 (1986). – reference: 5) 林洋, 内藤周幸, 川村光信, 宮崎滋, 加藤泰一, 木下誠. 松島照彦, 橋本佳明, 渡辺毅, 寺本民生: 高脂血症薬の治療効果とリンパ球LDLレセプター―クリノフィブラートを用いた成績―. 動脈硬化, 12: 303, 308 (1984). – reference: 7) Tsujita, Y., Kuroda, M., Shimada, Y., Tanzawa, K., Arai, M., Kaneko, I., Tanaka, M., Masuda, H., Tarumi, C., Watanabe, Y. and Fujii, S.: CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. Biochim. Biophys. Acta, 877: 50-60 (1986). – reference: 4) Goldstein, J. L., Brown, M. S. and Stone, N. J.: Genetics of the LDL receptor: Evidence that the mutations affecting binding and internalization are alleic. Cell, 12: 629-631 (1977). |
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| Subtitle | CMG-CoA reductase阻害剤(CS-514)を用いて |
| Title | リンパ球のmitogen反応性によるLDL receptor活性の検討 |
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