Serum platelet-activating factor (PAF) acetylhydrolase of children with bronchial asthma
Platelet-activating factor (PAF) acetylhydrolase has been recognized as an enzyme to inactivate PAF. We developed the convenient method to determine human serum PAF acetylhydrolase activity, that was based on the measurement of [14C] -acetate from 1-O-alkyl-2- [14C] -acetyl-sn-glycero-3-phosphocholi...
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| Published in | Ensho Vol. 8; no. 4; pp. 327 - 333 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japanese Society of Inflammation and Regeneration
01.07.1988
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0389-4290 1884-4006 |
| DOI | 10.2492/jsir1981.8.327 |
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| Abstract | Platelet-activating factor (PAF) acetylhydrolase has been recognized as an enzyme to inactivate PAF. We developed the convenient method to determine human serum PAF acetylhydrolase activity, that was based on the measurement of [14C] -acetate from 1-O-alkyl-2- [14C] -acetyl-sn-glycero-3-phosphocholine on the precipitation of the complex of radioactive substrate and albumin by adding trichloro acetic acid to the incubation mixture. Thirty-two subjects with the deficiency of serum PAF acetylhydrolase were found in 816 healthy adult Japanese. The low PAF acetylhydrolase activity in the deficient serum was not due to the presence of the enzyme inhibitor. Both the sensitivity to PAF and the metabolism of PAF in platelets from subjects with PAF acetylhydrolase deficiency were almost the same as that of the normal subjects. The deficiency in serum PAF acetylhydrolase is apparently transmitted according to autosomal recessive heredity among four Japanese families. Asthmatic children were grouped into five classes (Remission, Wheezy, Mild, Moderate and Severe groups) on the basis of symptoms according to the grade of bronchial asthma of Japanese Society of Pediatric Allergy and Clinitical Immunology. The probability of PAF acetylhydrolase deficiency in group with severe symptoms (Moderate and Severe, 5 subjects per 42) was significantly higher than that in a healthy group without a history of wheezy (one subject per 36), a group with slight symptoms (Remission and Wheezy, one subject per 100) and healthy adult Japanese (32 subjects per 816) . These results suggest that the deficiency of serum PAF acetylhydrolase might be one of factors which lead asthmatic children to more severe state in respiratory symptoms. |
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| AbstractList | Platelet-activating factor (PAF) acetylhydrolase has been recognized as an enzyme to inactivate PAF. We developed the convenient method to determine human serum PAF acetylhydrolase activity, that was based on the measurement of [14C] -acetate from 1-O-alkyl-2- [14C] -acetyl-sn-glycero-3-phosphocholine on the precipitation of the complex of radioactive substrate and albumin by adding trichloro acetic acid to the incubation mixture. Thirty-two subjects with the deficiency of serum PAF acetylhydrolase were found in 816 healthy adult Japanese. The low PAF acetylhydrolase activity in the deficient serum was not due to the presence of the enzyme inhibitor. Both the sensitivity to PAF and the metabolism of PAF in platelets from subjects with PAF acetylhydrolase deficiency were almost the same as that of the normal subjects. The deficiency in serum PAF acetylhydrolase is apparently transmitted according to autosomal recessive heredity among four Japanese families. Asthmatic children were grouped into five classes (Remission, Wheezy, Mild, Moderate and Severe groups) on the basis of symptoms according to the grade of bronchial asthma of Japanese Society of Pediatric Allergy and Clinitical Immunology. The probability of PAF acetylhydrolase deficiency in group with severe symptoms (Moderate and Severe, 5 subjects per 42) was significantly higher than that in a healthy group without a history of wheezy (one subject per 36), a group with slight symptoms (Remission and Wheezy, one subject per 100) and healthy adult Japanese (32 subjects per 816) . These results suggest that the deficiency of serum PAF acetylhydrolase might be one of factors which lead asthmatic children to more severe state in respiratory symptoms. |
| Author | Matsumoto, Makoto Miwa, Masao Sakata, Shigeyo Suzuki, Yasuo Miyake, Takeshi Sugatani, Junko Yamanaka, Tatsuhiro Araki, Yuji |
| Author_xml | – sequence: 1 fullname: Suzuki, Yasuo organization: Department of Biochemistry, School of Pharmaceutial Science, University of Shizuoka – sequence: 1 fullname: Yamanaka, Tatsuhiro organization: Department of Pediatrics, Faculty of Medicine, The University of Tokyo – sequence: 1 fullname: Sugatani, Junko organization: Department of Medical Chemistry, Kansai Medical School – sequence: 1 fullname: Araki, Yuji organization: Shizuoka Red Cross Blood Center – sequence: 1 fullname: Miyake, Takeshi organization: Division of Allergy, Clinical Immunology and Infections Diseases, Shizuoka Children's Hospital – sequence: 1 fullname: Sakata, Shigeyo organization: Shizuoka Red Cross Blood Center – sequence: 1 fullname: Miwa, Masao organization: Department of Biochemistry, School of Pharmaceutial Science, University of Shizuoka – sequence: 1 fullname: Matsumoto, Makoto organization: Department of Biochemistry, School of Pharmaceutial Science, University of Shizuoka |
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| References | 10) Lee, T-C., Malone, B., Wasserman, S.I., Fitzgerald, V., Snyder, F.: Activities of enzymes that metabolize platelet-activating factor (1-alkyl-2 -acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. Biochem. Biophys. Res. Commun. 105: 1303-1308, 1982. 4) McManus, L.M.: Pathobiology of platelet-acti-vating factors. Pathol. Immunopathol. Res. 5: 104-117, 1986. 21) 山中龍宏, 山中令子, 三輪匡男: 川崎病患者血清中のPAFアセチルハイドロラーゼ活性. 日本小児科学会雑誌92: 287-289, 1988. 2) Demopoulos, C.A., Pinckard, R.N., Hanahan, D. J.: Platelet-activating factor: Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine as the active components. J. Biol. Chem. 254: 9355-9358, 1979. 14) Sugatani, J., Miwa, M., Hanahan, D.J. : Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (Chymotryptic protease inhibitor) . J. Biol. Chem. 262: 5740-5747, 1987. 15) 三宅健, 河盛重造, 吉田隆実, 平尾敬男, 逢坂文夫, 松木秀明, 春日斉: 喘鳴の既往学童の頻度, および重症度の推移と血清学的検査成績との関連について. アレルギー34: 939-947, 1985. 5) Halonen, M., Palmer, J.D., Lohman, I.C., McManus, L.M., Pinckard, R.N.: Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine (AGEPC) , a mediator of IgE anaphylaxis in the rabbit. Am. Rev. Respir. Dis. 122: 915-924, 1980. 22) Lynch, J.M., Henson, P.M.: The intracellular retention of newly synthesized platelet-activating factor. J. Immunol. 137: 2653-2661, 1986. 24) Yanoshita, R., Kudo, I., Ikizawa, K., Chang, H.W., Kobayashi, S., Ohno, M., Nojima S., Inoue, K.: Hydrolysis of platelet activating factor and its analogs by acetylhydrolase. J. Biochem. 103: 815-819, 1988. 11) Miwa, M., Hill, C., Kumar, R., Sugatani, J., Olson, MS., Hanahan, D.J.: Occurence of an endogenous inhibitor of platelet-activating factor in rat liver. J. Biol. Chem. 262: 527-530, 1987. 16) Stafforini, D., McIntyre, T.M., Carter, M.E., Prescott, S.M.: Human plasma platelet-activating factor acetylhydrolase. J. Biol. Chem. 262: 4215-4222, 1987. 7) Blank, M.L., Hall, M.N., Cress, E.A., Snyder, F: Inactivation of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by a plasma acetylhydrolase: Higher activities in hypertensive rats. Biochem. Biophys. Res. Commun. 113: 666-671, 1983. 17) Malone, B., Lee, T-C., Snyder, F.: Inactivation of platelet activating factor by rabbit platelets: Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to tetraenoic acylated product. J. Biol. Chem. 260: 1531-1534, 1985. 8) Blank, M.L., Lee, T-C., Fitzgerald, V., Snyder, F.: A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) . J. Biol. Chem. 256: 175-178, 1981. 20) Vargafig, B.B.: Bronchopulmonary pharmacology of PAF-acether. Platelet-activating factor and related lipid mediators. (ed. Snyder, F.) , Plenum Press, New York, 1987, p 341-354. 3) Braquet, P., Touqui, L., Shen, T.Y., Vargaftig, B.B.: Perspectives in platelet-activating factor research. Pharmacol. Rev. 39: 97-145, 1987. 9) Nijssen, J.G., Roosenboom, C.F.P., van den Bosch, H.: Identification of a calcium-indepen-dent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether) . Biochim. Biophys. Acta 876: 611-618, 1986. 1) Benveniste, J., Henson, P.M., Cochrane, C.G.: Leukocyte-dependent histamine release from rabbit platelet. J. Exp. Med. 136: 1356-1377, 1972. 19) Morley, J., Page, C.P., Mazzoni, L., Sanjar, S.: Effects of ketotifen upon responses to platelet activating factor : A basis for asthma prophylaxis. Annals of Allergy 56: 335-340, 1986. 23) Oda, M., Satouchi, K., Yasunaga, K., Saito, K.: Polymorphonuclear leukocyte-platelet interactions: Acetylglyceryl ether phosphocholineinduced platelet activation under stimulation with chemotactic peptide. J. Biochem. 100: 1117-1123, 1986. 6) Farr, R.S., Cox, C.P., Wardlow, M.L., Jorgensen, R.: Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates plateletactivating factor (PAF) . Clin. Immunol. Immunopathol. 15: 318-330, 1980. 18) Chilton, F.H., O'Flaherty, J.T., Ellis, J.M., Swendsen, C.L., Wykle, R.L.: Metabolic fate of platelet-activating factor in neutrophils. J. Biol. Chem. 258: 6357-6361, 1983. 13) Miwa, M., Matsumoto, M., Tezuka, M., Okada, S., Ohsuka, S., Fujiwake, H.: Quantitative fluorographic detection of 3H and 14C on two-dimensional thin-layer chromatographic sheets by an ultra-high-sensitivity TV camera system. Anal. Biochem. 152: 391-395, 1986. 12) Pinckard, R.N., Farr, R.S., Hanahan, D.J. : Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in rico during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J. Immunol. 123: 1847-1857, 1979. |
| References_xml | – reference: 20) Vargafig, B.B.: Bronchopulmonary pharmacology of PAF-acether. Platelet-activating factor and related lipid mediators. (ed. Snyder, F.) , Plenum Press, New York, 1987, p 341-354. – reference: 3) Braquet, P., Touqui, L., Shen, T.Y., Vargaftig, B.B.: Perspectives in platelet-activating factor research. Pharmacol. Rev. 39: 97-145, 1987. – reference: 16) Stafforini, D., McIntyre, T.M., Carter, M.E., Prescott, S.M.: Human plasma platelet-activating factor acetylhydrolase. J. Biol. Chem. 262: 4215-4222, 1987. – reference: 23) Oda, M., Satouchi, K., Yasunaga, K., Saito, K.: Polymorphonuclear leukocyte-platelet interactions: Acetylglyceryl ether phosphocholineinduced platelet activation under stimulation with chemotactic peptide. J. Biochem. 100: 1117-1123, 1986. – reference: 4) McManus, L.M.: Pathobiology of platelet-acti-vating factors. Pathol. Immunopathol. Res. 5: 104-117, 1986. – reference: 14) Sugatani, J., Miwa, M., Hanahan, D.J. : Platelet-activating factor stimulation of rabbit platelets is blocked by serine protease inhibitor (Chymotryptic protease inhibitor) . J. Biol. Chem. 262: 5740-5747, 1987. – reference: 10) Lee, T-C., Malone, B., Wasserman, S.I., Fitzgerald, V., Snyder, F.: Activities of enzymes that metabolize platelet-activating factor (1-alkyl-2 -acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. Biochem. Biophys. Res. Commun. 105: 1303-1308, 1982. – reference: 5) Halonen, M., Palmer, J.D., Lohman, I.C., McManus, L.M., Pinckard, R.N.: Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine (AGEPC) , a mediator of IgE anaphylaxis in the rabbit. Am. Rev. Respir. Dis. 122: 915-924, 1980. – reference: 12) Pinckard, R.N., Farr, R.S., Hanahan, D.J. : Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in rico during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J. Immunol. 123: 1847-1857, 1979. – reference: 21) 山中龍宏, 山中令子, 三輪匡男: 川崎病患者血清中のPAFアセチルハイドロラーゼ活性. 日本小児科学会雑誌92: 287-289, 1988. – reference: 1) Benveniste, J., Henson, P.M., Cochrane, C.G.: Leukocyte-dependent histamine release from rabbit platelet. J. Exp. Med. 136: 1356-1377, 1972. – reference: 2) Demopoulos, C.A., Pinckard, R.N., Hanahan, D. J.: Platelet-activating factor: Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine as the active components. J. Biol. Chem. 254: 9355-9358, 1979. – reference: 15) 三宅健, 河盛重造, 吉田隆実, 平尾敬男, 逢坂文夫, 松木秀明, 春日斉: 喘鳴の既往学童の頻度, および重症度の推移と血清学的検査成績との関連について. アレルギー34: 939-947, 1985. – reference: 9) Nijssen, J.G., Roosenboom, C.F.P., van den Bosch, H.: Identification of a calcium-indepen-dent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether) . Biochim. Biophys. Acta 876: 611-618, 1986. – reference: 6) Farr, R.S., Cox, C.P., Wardlow, M.L., Jorgensen, R.: Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates plateletactivating factor (PAF) . Clin. Immunol. Immunopathol. 15: 318-330, 1980. – reference: 8) Blank, M.L., Lee, T-C., Fitzgerald, V., Snyder, F.: A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) . J. Biol. Chem. 256: 175-178, 1981. – reference: 19) Morley, J., Page, C.P., Mazzoni, L., Sanjar, S.: Effects of ketotifen upon responses to platelet activating factor : A basis for asthma prophylaxis. Annals of Allergy 56: 335-340, 1986. – reference: 7) Blank, M.L., Hall, M.N., Cress, E.A., Snyder, F: Inactivation of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by a plasma acetylhydrolase: Higher activities in hypertensive rats. Biochem. Biophys. Res. Commun. 113: 666-671, 1983. – reference: 13) Miwa, M., Matsumoto, M., Tezuka, M., Okada, S., Ohsuka, S., Fujiwake, H.: Quantitative fluorographic detection of 3H and 14C on two-dimensional thin-layer chromatographic sheets by an ultra-high-sensitivity TV camera system. Anal. Biochem. 152: 391-395, 1986. – reference: 17) Malone, B., Lee, T-C., Snyder, F.: Inactivation of platelet activating factor by rabbit platelets: Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to tetraenoic acylated product. J. Biol. Chem. 260: 1531-1534, 1985. – reference: 24) Yanoshita, R., Kudo, I., Ikizawa, K., Chang, H.W., Kobayashi, S., Ohno, M., Nojima S., Inoue, K.: Hydrolysis of platelet activating factor and its analogs by acetylhydrolase. J. Biochem. 103: 815-819, 1988. – reference: 22) Lynch, J.M., Henson, P.M.: The intracellular retention of newly synthesized platelet-activating factor. J. Immunol. 137: 2653-2661, 1986. – reference: 11) Miwa, M., Hill, C., Kumar, R., Sugatani, J., Olson, MS., Hanahan, D.J.: Occurence of an endogenous inhibitor of platelet-activating factor in rat liver. J. Biol. Chem. 262: 527-530, 1987. – reference: 18) Chilton, F.H., O'Flaherty, J.T., Ellis, J.M., Swendsen, C.L., Wykle, R.L.: Metabolic fate of platelet-activating factor in neutrophils. J. Biol. Chem. 258: 6357-6361, 1983. |
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| SubjectTerms | acetylhydrolase deficiency bronchial asthma PAF respiratory symptoms serum PAF acetylhydrolase |
| Title | Serum platelet-activating factor (PAF) acetylhydrolase of children with bronchial asthma |
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