A Pediatric Case of Acute Non-lymphocytic Leukemia with Both Granuloid and Monocytic Features in the Esterase Activity
We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The b...
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| Published in | The Japanese Journal of Pediatric Hematology Vol. 2; no. 4; pp. 434 - 438 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY
20.12.1988
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0913-8706 1884-4723 |
| DOI | 10.11412/jjph1987.2.434 |
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| Abstract | We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The bone marrow contained 96% of leukemic cells which had promyelocytoid morphology. The cells were strongly positive for peroxidase. They were positive for both naphthol-AS-D-chloroacetate and α-naphthyl butyrate esterases, and the latter esterase activity was inhibited by NaF. The chromosome analysis revealed an abnormal 45, X, -Y, t (1p-; 14q+), 9q+, 12q- pattern. The leukemia appears to be an M3 type of ANLL with unusual cytological features. |
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| AbstractList | We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The bone marrow contained 96% of leukemic cells which had promyelocytoid morphology. The cells were strongly positive for peroxidase. They were positive for both naphthol-AS-D-chloroacetate and α-naphthyl butyrate esterases, and the latter esterase activity was inhibited by NaF. The chromosome analysis revealed an abnormal 45, X, -Y, t (1p-; 14q+), 9q+, 12q- pattern. The leukemia appears to be an M3 type of ANLL with unusual cytological features. |
| Author | AKABANE, Taro NAKAHATA, Tatsutoshi KOMIYAMA, Atsushi KAWAI, Hiroshi AONUMA, Kesashi MOROHASHI, Fumio ARAI, Katsuyuki |
| Author_xml | – sequence: 1 fullname: AONUMA, Kesashi organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: MOROHASHI, Fumio organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: ARAI, Katsuyuki organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: NAKAHATA, Tatsutoshi organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: KAWAI, Hiroshi organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: AKABANE, Taro organization: Department of Pediatrics, Shinshu University School of Medicine – sequence: 1 fullname: KOMIYAMA, Atsushi organization: Department of Pediatrics, Shinshu University School of Medicine |
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| References | 4) Terrin BN, Studer EJ, Wood N, et al : Childhood leukemia with simultaneously expressed myeloid and lymphoid markers suggesting stem cell origin. Am J Hematol 20 : 175-181, 1985 12) Berger R : Karyotype and cell phenotypes in primary acute leukemias. Blood Cell 7 : 287-292, 1981 11) McCulloch EA : Stem cells in normal and leukemic hemopoiesis (Henry Stratton lecture). Blood 62 : 1-13, 1983 1) Foon KA, Schroff RW, Gale RP : Surface markers on leukemia and lymphoma cells : Recent advances. Blood 60 : 1-18, 1982 7) 諸橋文雄, 青沼架佐賜, 加藤正雄, 他 : 小児急性非リンパ性白血病 (ANLL) に対するmodified VAPA療法の治療成績.臨床血液27 : 2101-2106, 1986 6) Weinstein H J, Mayer RJ, Rosental DS, et al : Chemotherapy for acute myelogenous leukemia in children and adults : VAPA update. Blood 62 : 315-319, 1983 3) Mirro J, Zpf TF, Pui CH, et al : Acute mixed lineage leukemia. Clinicopathologic correlations and prognostic significance. Blood 66 : 1115-1123, 1985 8) 小宮山淳, 赤羽太郎, 植田 穣, 他 : 小児急性非リンパ性白血病のFAB分類.小児-血液がんの病態と治療, 藤本孟男編 癌と化学療法社 東京 1987, 44-50 10) Palumbo A, Minowada J, Erikson J, et al : Lineage infidelity of a human myelogenous leukemia cell line. Blood 64 : 1059-1063, 1984 5) Tulliez M, Vernant JP, Breton-Gorius J, et al : Pseudo-Chediak-Higashi Anomaly in a case of acute myeloid leukemia : Electron microscopic studies. Blood 54 : 863-871, 1979 9) 小山隆三, 石川邦嗣, 小関純一, 他 : 組織化学上興味ある所見を呈した前骨髄球性白血病の1例.臨床血液20 : 987-993, 1979 13) Sakurai M, Sasaki M, Kamada N, et al : A summary of cytogenetic, morphologic, and clinical data on t (8q-; 21q+) and t (15q+; 17q-) translocation leukemias in Japan. Cancer Genet Cytogenet 7 : 59-65, 1982 2) Tomonaga M, Yoshida Y, Tagawa M, et al : Cytochemistry of acute promyelocytic leukemia, (M3) : Leukemic promyelocytes exhibit hetero-geneous patterns in cellular differentiation. Blood 66 : 350-357, 1985 |
| References_xml | – reference: 7) 諸橋文雄, 青沼架佐賜, 加藤正雄, 他 : 小児急性非リンパ性白血病 (ANLL) に対するmodified VAPA療法の治療成績.臨床血液27 : 2101-2106, 1986 – reference: 11) McCulloch EA : Stem cells in normal and leukemic hemopoiesis (Henry Stratton lecture). Blood 62 : 1-13, 1983 – reference: 9) 小山隆三, 石川邦嗣, 小関純一, 他 : 組織化学上興味ある所見を呈した前骨髄球性白血病の1例.臨床血液20 : 987-993, 1979 – reference: 8) 小宮山淳, 赤羽太郎, 植田 穣, 他 : 小児急性非リンパ性白血病のFAB分類.小児-血液がんの病態と治療, 藤本孟男編 癌と化学療法社 東京 1987, 44-50 – reference: 12) Berger R : Karyotype and cell phenotypes in primary acute leukemias. Blood Cell 7 : 287-292, 1981 – reference: 10) Palumbo A, Minowada J, Erikson J, et al : Lineage infidelity of a human myelogenous leukemia cell line. Blood 64 : 1059-1063, 1984 – reference: 3) Mirro J, Zpf TF, Pui CH, et al : Acute mixed lineage leukemia. Clinicopathologic correlations and prognostic significance. Blood 66 : 1115-1123, 1985 – reference: 5) Tulliez M, Vernant JP, Breton-Gorius J, et al : Pseudo-Chediak-Higashi Anomaly in a case of acute myeloid leukemia : Electron microscopic studies. Blood 54 : 863-871, 1979 – reference: 13) Sakurai M, Sasaki M, Kamada N, et al : A summary of cytogenetic, morphologic, and clinical data on t (8q-; 21q+) and t (15q+; 17q-) translocation leukemias in Japan. Cancer Genet Cytogenet 7 : 59-65, 1982 – reference: 1) Foon KA, Schroff RW, Gale RP : Surface markers on leukemia and lymphoma cells : Recent advances. Blood 60 : 1-18, 1982 – reference: 4) Terrin BN, Studer EJ, Wood N, et al : Childhood leukemia with simultaneously expressed myeloid and lymphoid markers suggesting stem cell origin. Am J Hematol 20 : 175-181, 1985 – reference: 2) Tomonaga M, Yoshida Y, Tagawa M, et al : Cytochemistry of acute promyelocytic leukemia, (M3) : Leukemic promyelocytes exhibit hetero-geneous patterns in cellular differentiation. Blood 66 : 350-357, 1985 – reference: 6) Weinstein H J, Mayer RJ, Rosental DS, et al : Chemotherapy for acute myelogenous leukemia in children and adults : VAPA update. Blood 62 : 315-319, 1983 |
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| Snippet | We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with... |
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| Title | A Pediatric Case of Acute Non-lymphocytic Leukemia with Both Granuloid and Monocytic Features in the Esterase Activity |
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