A Pediatric Case of Acute Non-lymphocytic Leukemia with Both Granuloid and Monocytic Features in the Esterase Activity

We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The b...

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Bibliographic Details
Published inThe Japanese Journal of Pediatric Hematology Vol. 2; no. 4; pp. 434 - 438
Main Authors AONUMA, Kesashi, MOROHASHI, Fumio, ARAI, Katsuyuki, NAKAHATA, Tatsutoshi, KAWAI, Hiroshi, AKABANE, Taro, KOMIYAMA, Atsushi
Format Journal Article
LanguageJapanese
Published THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY 20.12.1988
Subjects
ANLL
esterase
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ISSN0913-8706
1884-4723
DOI10.11412/jjph1987.2.434

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Summary:We report a 3-year-old boy having acute non-lymphocytic leukemia (ANLL) with both granuloid and monocytic features in the esterase activity. He presented with mild anemia, bleeding tendency, hepatomegaly and lymphadenopathy. The white blood cell count was 17, 300/μl with 34% of leukemia cells. The bone marrow contained 96% of leukemic cells which had promyelocytoid morphology. The cells were strongly positive for peroxidase. They were positive for both naphthol-AS-D-chloroacetate and α-naphthyl butyrate esterases, and the latter esterase activity was inhibited by NaF. The chromosome analysis revealed an abnormal 45, X, -Y, t (1p-; 14q+), 9q+, 12q- pattern. The leukemia appears to be an M3 type of ANLL with unusual cytological features.
ISSN:0913-8706
1884-4723
DOI:10.11412/jjph1987.2.434