日本人のアセトアミノフェン過量摂取患者におけるN-アセチルシステイン投与指標の検討
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| Published in | 医療薬学 Vol. 51; no. 7; pp. 435 - 442 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人日本医療薬学会
10.07.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1346-342X 1882-1499 |
| DOI | 10.5649/jjphcs.51.435 |
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| Author | 新田 滉基 木村 美智男 森 光輝 宇佐美 英績 |
|---|---|
| Author_xml | – sequence: 1 fullname: 新田 滉基 organization: 大垣市民病院 薬剤部 – sequence: 1 fullname: 木村 美智男 organization: 大垣市民病院 薬剤部 – sequence: 1 fullname: 宇佐美 英績 organization: 大垣市民病院 薬剤部 – sequence: 1 fullname: 森 光輝 organization: 大垣市民病院 薬剤部 |
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| DOI | 10.5649/jjphcs.51.435 |
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| References | 2）Keaveney A, Peters E, Way B, Effects of acetaminophen on risk taking, Soc Cogn Affect Neurosci, 2020, 15, 725-732. 4）Mazaleuskaya LL, Sangkuhl K, Thorn CF, Fitzgerald GA, Altman RB, Klein TE, PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses, Pharmacogenet Genomics, 2015, 25, 416-426. 1）Ishitsuka Y, Kondo Y, Kadowaki D, Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?, Biol Pharm Bull, 2020, 43, 195-206. 18）Shekunov J, Lewis CP, Vande Voort JL, Bostwick JM, Romanowicz M, Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity, Psychiatric Services, 2021, 72, 758-765. 9）Betten DP, Cantrell FL, Thomas SC, Williams SR, Clark RF, A Prospective Evaluation of Shortened Course Oral N-Acetylcysteine for the Treatment of Acute Acetaminophen Poisoning, Ann Emerg Med, 2007, 50, 272-279. 10）Licata A, Minissale MG, Stankeviit S, Sanabria-Cabrera J, Lucena MI, Andrade RJ, Almasio PL, N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review, Front Pharmacol, 2022, 13, 828565. doi: 10.3389/fphar.2022.828565. 22）Dawson J, Fulton R, Mcinnes GT, Morton R, Morrison D, Padmanabhan S, Hewitt J, Meredith P, Muir S, Dominiczak AF, Walters MR, Acetaminophen use and change in blood pressure in a hypertensive population, J Hypertens, 2013, 31, 1485-1490. 11）高山真理子, 中嶋真理子, 藤澤真奈美, 堀 寧, 磯貝 隆, 小田 明, 勝山新一朗, 広瀬保夫, 吉岡敏治, 急性アセトアミノフェン中毒患者の推定服用量と重症化の関係－新潟市民病院39症例の調査より－, 日本病院薬剤師会雑誌, 2005, 41, 720-722. 15）Tahara Y, Moji K, Aoyagi K, Tsunawake N, Muraki S, Mascie-Taylor CGN, Age-related pattern of body density and body composition of Japanese men and women 18-59 years of age, Am J Hum Biol, 2002, 14, 743-752. 14）Fryar CD, Kruszon-Moran D, Gu Q, Ogden CL, Mean body weight, height, waist circumference, and body mass index among adults: United States, 1999-2000 through 2015-2016, Natl Health Stat Report, 2018, 122, 1-16. 8）大谷典生, 一二三 亨, 北元 健, 小林憲太郎, 中谷宣章, 冨岡譲二, 本邦救急医療施設における薬物分析環境の現状と課題, 日本救急医学会雑誌, 2020, 31, 278-286. 6）Chomchai S, Mekavuthikul P, Phuditshinnapatra J, Chomchai C, Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram, Pharmacol Res Perspect, 2022, 10, e00920. doi: 10.1002/prp2.920. 16）Ueshima Y, Tsutsumi M, Takase S, Matsuda Y, Kawahara H, Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes, Alcohol Clin Exp Res, 1996, 20, 25-28. 12）Ooi SL, Green R, Pak SC, N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence, Biomed Res Int, 2018, 2018, 2469486. doi: 10.1155/2018/2469486. 13）Hodgman MJ, Garrard AR, A review of acetaminophen poisoning, Crit Care Clin, 2012, 4, 499-516. 20）Gyamlani GG, Parikh CR, Acetaminophen toxicity: Suicidal vs accidental, Crit Care, 2002, 6, 155-159. 3）Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S, Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity, Chem Res Toxicol, 2006, 19, 701-709. 5）Rumack BH, Matthew H, Acetaminophen poisoning and toxicity, Pediatrics, 1975, 55, 871-876. 7）Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH, Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose, N Engl J Med, 1988, 319, 1557-1562. 19）Shadman KA, Edmonson MB, Coller RJ, Sklansky DJ, Nacht CL, Zhao Q, Kelly MM, US Hospital Stays in Children and Adolescents With Acetaminophen Poisoning, Hosp Pediatr, 2022, 12, 60-67. 17）廣瀬正幸, 平川昭彦, 丹羽若菜, 東口貴彦, 田島康介, 加藤貴大, 山田成樹, 若年者の一般用医薬品による急性薬物中毒の現状, YAKUGAKU ZASSHI, 2021, 141, 1389-1392. 21）Macintyre IM, Turtle EJ, Farrah TE, Graham C, Dear JW, Webb DJ, Regular Acetaminophen Use and Blood Pressure in People with Hypertension: The PATH-BP Trial, Circulation, 2022, 145, 416-423. |
| References_xml | – reference: 13）Hodgman MJ, Garrard AR, A review of acetaminophen poisoning, Crit Care Clin, 2012, 4, 499-516. – reference: 4）Mazaleuskaya LL, Sangkuhl K, Thorn CF, Fitzgerald GA, Altman RB, Klein TE, PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses, Pharmacogenet Genomics, 2015, 25, 416-426. – reference: 10）Licata A, Minissale MG, Stankeviit S, Sanabria-Cabrera J, Lucena MI, Andrade RJ, Almasio PL, N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review, Front Pharmacol, 2022, 13, 828565. doi: 10.3389/fphar.2022.828565. – reference: 1）Ishitsuka Y, Kondo Y, Kadowaki D, Toxicological Property of Acetaminophen: The Dark Side of a Safe Antipyretic/Analgesic Drug?, Biol Pharm Bull, 2020, 43, 195-206. – reference: 20）Gyamlani GG, Parikh CR, Acetaminophen toxicity: Suicidal vs accidental, Crit Care, 2002, 6, 155-159. – reference: 8）大谷典生, 一二三 亨, 北元 健, 小林憲太郎, 中谷宣章, 冨岡譲二, 本邦救急医療施設における薬物分析環境の現状と課題, 日本救急医学会雑誌, 2020, 31, 278-286. – reference: 5）Rumack BH, Matthew H, Acetaminophen poisoning and toxicity, Pediatrics, 1975, 55, 871-876. – reference: 17）廣瀬正幸, 平川昭彦, 丹羽若菜, 東口貴彦, 田島康介, 加藤貴大, 山田成樹, 若年者の一般用医薬品による急性薬物中毒の現状, YAKUGAKU ZASSHI, 2021, 141, 1389-1392. – reference: 14）Fryar CD, Kruszon-Moran D, Gu Q, Ogden CL, Mean body weight, height, waist circumference, and body mass index among adults: United States, 1999-2000 through 2015-2016, Natl Health Stat Report, 2018, 122, 1-16. – reference: 18）Shekunov J, Lewis CP, Vande Voort JL, Bostwick JM, Romanowicz M, Clinical Characteristics, Outcomes, Disposition, and Acute Care of Children and Adolescents Treated for Acetaminophen Toxicity, Psychiatric Services, 2021, 72, 758-765. – reference: 11）高山真理子, 中嶋真理子, 藤澤真奈美, 堀 寧, 磯貝 隆, 小田 明, 勝山新一朗, 広瀬保夫, 吉岡敏治, 急性アセトアミノフェン中毒患者の推定服用量と重症化の関係－新潟市民病院39症例の調査より－, 日本病院薬剤師会雑誌, 2005, 41, 720-722. – reference: 15）Tahara Y, Moji K, Aoyagi K, Tsunawake N, Muraki S, Mascie-Taylor CGN, Age-related pattern of body density and body composition of Japanese men and women 18-59 years of age, Am J Hum Biol, 2002, 14, 743-752. – reference: 16）Ueshima Y, Tsutsumi M, Takase S, Matsuda Y, Kawahara H, Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes, Alcohol Clin Exp Res, 1996, 20, 25-28. – reference: 19）Shadman KA, Edmonson MB, Coller RJ, Sklansky DJ, Nacht CL, Zhao Q, Kelly MM, US Hospital Stays in Children and Adolescents With Acetaminophen Poisoning, Hosp Pediatr, 2022, 12, 60-67. – reference: 12）Ooi SL, Green R, Pak SC, N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence, Biomed Res Int, 2018, 2018, 2469486. doi: 10.1155/2018/2469486. – reference: 7）Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH, Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose, N Engl J Med, 1988, 319, 1557-1562. – reference: 3）Mutlib AE, Goosen TC, Bauman JN, Williams JA, Kulkarni S, Kostrubsky S, Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity, Chem Res Toxicol, 2006, 19, 701-709. – reference: 2）Keaveney A, Peters E, Way B, Effects of acetaminophen on risk taking, Soc Cogn Affect Neurosci, 2020, 15, 725-732. – reference: 6）Chomchai S, Mekavuthikul P, Phuditshinnapatra J, Chomchai C, Sensitivity of dose-estimations for acute acetaminophen overdose in predicting hepatotoxicity risk using the Rumack-Matthew Nomogram, Pharmacol Res Perspect, 2022, 10, e00920. doi: 10.1002/prp2.920. – reference: 22）Dawson J, Fulton R, Mcinnes GT, Morton R, Morrison D, Padmanabhan S, Hewitt J, Meredith P, Muir S, Dominiczak AF, Walters MR, Acetaminophen use and change in blood pressure in a hypertensive population, J Hypertens, 2013, 31, 1485-1490. – reference: 21）Macintyre IM, Turtle EJ, Farrah TE, Graham C, Dear JW, Webb DJ, Regular Acetaminophen Use and Blood Pressure in People with Hypertension: The PATH-BP Trial, Circulation, 2022, 145, 416-423. – reference: 9）Betten DP, Cantrell FL, Thomas SC, Williams SR, Clark RF, A Prospective Evaluation of Shortened Course Oral N-Acetylcysteine for the Treatment of Acute Acetaminophen Poisoning, Ann Emerg Med, 2007, 50, 272-279. |
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| Title | 日本人のアセトアミノフェン過量摂取患者におけるN-アセチルシステイン投与指標の検討 |
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