Platimun Compounds Involving New Anti-cancer Mechanism

• Published in: Biomedical Research on Trace Elements Vol. 22; no. 1; pp. 22 - 26
• Main Author: Odani, Akira
• Format: Journal Article
• Language: English; Japanese
• Published: Osaka Japan Society for Biomedical Research on Trace Elements 2011; 日本微量元素学会; Japan Science and Technology Agency
• Subjects: Anthracene; anti-cancer Pt(II) complexes; aromatic ring stacking; cisplatin resistance; cisplatin-DNA adduct; Cytotoxicity; Deoxyribonucleic acid; DNA; proteasome

Cisplatin, clinically used anticancer Pt(II) complex, has been believed to attack DNA to form Pt-N7(Guanine) coordination, and Pt-G bond is protected from DNA repair enzyme by the aromatic ring stacking between Pt-G and Phe side chain in Pt-DNA-HMG protein adduct. The adduct mimicked 4N coordinated...