頭頸部扁平上皮癌組織における基底膜糖タンパタラミニンの分布 ラミニン染色性と臨床像, 病理組織像との関係
頭頸部扁平上皮癌組織におけるラミニンの分布を免疫組織染色にて調べたところ癌胞巣周囲に分布が認められたがその程度はさまざまであった. 癌胞巣周囲の染色様態を正常型, 断裂型, 消失型の3群に分類し臨床的悪性度, 角化度, 浸潤様式との関係を検討した. 断裂型, 消失型でリンパ節転移, リンパ節再発の率が有意に高かった. 遠隔転移については消失型に遠隔転移が有意に多くみられた. 角化度の強い癌で正常型の比率が有意に高かった. 一方, 原発巣の大きさ, 浸潤様式とは有意な関係は認められなかった. 5年生存率は正常型で67.2%, 断裂型で52.1%, 消失型で31.0%であった....
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| Published in | 日本耳鼻咽喉科学会会報 Vol. 98; no. 2; pp. 216 - 225,351 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
一般社団法人 日本耳鼻咽喉科学会
20.02.1995
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0030-6622 1883-0854 |
| DOI | 10.3950/jibiinkoka.98.216 |
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| Abstract | 頭頸部扁平上皮癌組織におけるラミニンの分布を免疫組織染色にて調べたところ癌胞巣周囲に分布が認められたがその程度はさまざまであった. 癌胞巣周囲の染色様態を正常型, 断裂型, 消失型の3群に分類し臨床的悪性度, 角化度, 浸潤様式との関係を検討した. 断裂型, 消失型でリンパ節転移, リンパ節再発の率が有意に高かった. 遠隔転移については消失型に遠隔転移が有意に多くみられた. 角化度の強い癌で正常型の比率が有意に高かった. 一方, 原発巣の大きさ, 浸潤様式とは有意な関係は認められなかった. 5年生存率は正常型で67.2%, 断裂型で52.1%, 消失型で31.0%であった. |
|---|---|
| AbstractList | 頭頸部扁平上皮癌組織におけるラミニンの分布を免疫組織染色にて調べたところ癌胞巣周囲に分布が認められたがその程度はさまざまであった. 癌胞巣周囲の染色様態を正常型, 断裂型, 消失型の3群に分類し臨床的悪性度, 角化度, 浸潤様式との関係を検討した. 断裂型, 消失型でリンパ節転移, リンパ節再発の率が有意に高かった. 遠隔転移については消失型に遠隔転移が有意に多くみられた. 角化度の強い癌で正常型の比率が有意に高かった. 一方, 原発巣の大きさ, 浸潤様式とは有意な関係は認められなかった. 5年生存率は正常型で67.2%, 断裂型で52.1%, 消失型で31.0%であった. |
| Author | 鈴木, 守 |
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| Copyright | 日本耳鼻咽喉科学会 |
| Copyright_xml | – notice: 日本耳鼻咽喉科学会 |
| DOI | 10.3950/jibiinkoka.98.216 |
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| References | 19) Crissman JD, Liu WY, Gluckman JL: Prognostic Value of Histopathologic Parameters in Squamous Cell Carcinoma of the Oropharynx. Cancer 54: 2995-3001, 1984. 6) Charpin C, Lissitzky JC, Jacquemier J: Immunohistochemical Detection of Laminin in 98 Human Breast Carcinomas. A Light and Electron Microscopic Study. Human Pathology 17: 355-365, 1986. 30) 村上匡孝, 三牧三郎, 斎藤裕子, 和田義正, 西山康之他: 頭頸部扁平上皮癌巣周囲膜IV型コラゲンの免疫組織学的研究-生検組織の癌巣周囲膜と頸部リンパ節転移-, 日耳鼻95: 1773-1784, 1992. 21) Broders AC: Carcinoma. Grading and practical application. Arch Pathol 2: 376-381, 1926. 29) Hirota J, Yoneda K, Osaki T: Basement membrane type IV collagen in oral squamous cell carcinoma. HEAD & NECK, September/October: 400-405, 1990. 13) Vogel HP, Mendelsohn G: Laminin Immunostaining in Hyperplastic, Dysplastic, and Neoplastic Lesions of the Endometrium and Uterine Cervix. Obstetrics Gynecology 69: 794-799, 1987. 1) Foidert JM, Bere EWJ, Yaar M: Distribution and immunoelectron microscopic localization of laminin, a non-collagenous basement membrane glycoprotein. Lab Invest 42: 336-342, 1980. 31) 鈴木守, 高坂知節, 粟田口敏一, 橋本省: 頭頸部癌組織内のラミニン, タイプ4コラーゲン, フィブロネクチンの分布, 頭頸部腫瘍16: 26-29, 1990. 8) 樋口真秀, 大西丘倫, 有田憲生, 平賀章〓, 岩崎弘充他: ヒト悪性グリオーマにおけるfibronectinおよびfibronectin-receptorの免疫組織化学的局在-腫瘍浸潤との関連より-脳神経43: 17-23, 1991. 27) Heck LW, Blackburn WD, Irwin MH: Degradation of Basement Membrane Laminin by Human Neutrophil Elastase and Cathepsin G. Am J Pathol 136 (6): 1267-1274, 1990. 10) Visser R, Beek JMHV, Havenith MG: Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeal dysplasia and neoplasia. Histopathology 10: 171-180, 1986. 15) Forster SJ, Talbot IC, Critchley DR: Laminin and fibronectin in rectal adenocarcinoma: Relationship to tumour grade, stage and metastasis, Br J Cancer 50: 51-61, 1984. 43) Oguro K. Kazama T. Isemura M: Immunohistochemical Alterlations in Basement Membrane Components of Squamous Cell Carcinoma. J Invest Dermatol 96: 250-254, 1991 48) Natali PG, Nicotra MR, Bellocci M: Distribution of laminin and collagen type IV in benign and malignant lesions of melanocytic origin. Int J Cancer 35: 461-467, 1985. 16) Nishino T, Ishida T, Oka T: Prognostic Significance of Laminin in Adenocarcinoma of the Lung. J Surgical Oncology 43: 214-218, 1990. 37) 迎徹: 胃癌組織におけるFibronectin, Lamininの免疫組織学的検討. J Jpn Soc Cancer Ther 25: 2468-2476, 1990. 44) 橋本博, 黒田一秀, 坂下茂夫: 膀胱癌と基底膜特異蛋白laminin日泌尿会誌75: 580-590. 1984. 7) Joffe EBDK, Puricelli L, Mariotto R: Fibronectin and laminin expression in breast cancer and lymph node metastasis. Lack of correlation with fibronectin plasmatic levels. MEDICINA (Buenos Aires) 48: 499-505, 1988. 5) Liotta LA: Tumor invasion and metastasis. Role of the extracellular matrix. Rhoads memorial award lecture. Cancer Res 46: 1-7, 1986. 14) Forster SJ, Talbot IC, Clayton DJ: Tumor basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance. Int J Cancer 37: 813-817, 1986. 36) Takeda H: Immunohistochemical studies of basement membrane components in primary and metastatic lesions of early gastric cancer. J Nippon Med Sch 57: 160-171. 1990. 46) Daneker GW, Mercurio AM, Guerra L: Laminin Expression in Colorectal Carcinomas Varying in Degree of Differentiation. Arch Surg 122: 1470-1474, 1987. 38) Haglund C, Nordling S, Roberts PJ: Expression of laminin in pancreatic neoplasms and in chronic pancreatitis. Am J Surg Pathol 8: 669-676, 1984. 11) Bulleti C, Galassi A, Jasonni VM: Basement Membrane Components in Normal, Hyperplastic and Neoplastic Endometrium. Cancer 62: 142-149, 1988. 41) Charpin C, Kopp F, Schneider NP: Laminin immunodetection in tumorous and non-tumorous disorders of human thyroid. Bull Cancer 72: 6-15, 1985. 28) Lah TT, Buck MR, Honn KV: Degradation of laminin by human tumor cathepsin B. Clin Expl Metastasis 7 (4): 461-468, 1989. 25) Dickneite G, Sedlacek HH, Timpl R: Tumor Growth and Metastasis Increases the Serum Concentration of Basement Membrane Proteins. Behring Inst Mitt 78: 159-166, 1985. 12) Stenbäck F, Risteli J, Risteli L: Basement Membrane Laminin and Type IV Collagen in Endometrial Adenocarcinoma: Relation to Differentiation and Treatment. Oncology 42: 370-376, 1985. 32) Giordana MT, Germano I, Giaccone G: The Distribution of Laminin in Human Brain Tumors: An Immunohistochemical Study. Acta Neuropathol 67: 51-57, 1985. 18) Mori M, Shimono R, Kido A: Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study. Int J Cancer 47: 839-842, 1991. 2) Ekblom P, Miettinen M, Rapola J: Demonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues. Histochemistry 75: 301-307, 1982. 33) Sugihara H, Hattori T, Fujita S: Distribution of fibronectin and laminin in early and advanced signet-ring-cell carcinomas of the stomach. Int J Cancer 43: 263-269, 1989. 4) Liotta LA, Rao CN, Barsky SH: Tumor invasion and the extracellular matrix. Lab Invest 49: 636-649, 1983. 17) McComb RD, Bigner DD: Immunolocalization of Laminin in Neoplasms of the Central and Peripheral Nervous Systems. J Neuropathol Exp Neurol 44: 242-253, 1985. 40) Sinha AA, Gleason DF, Wilson MJ: Immunohistochemical Localization of Laminin in the basement Membranes of Normal, Hyperplastic, and Neoplastic Human Prostate. The Prostate 15: 299-313, 1989. 20) Jakobsson PA: Histologic grading of malignancy and prognosis in glottic carcinoma of the larynx. Centennial Conference on Laryngeal Cancer. New York: Appleton-Century-Crofts: 847-852, 1976. 26) Boyd D, Ziober B, Chakrabarty S: Examination of Urokinase Protein/Transcript Levels and Their Relationship with Laminin Degradation in Cultured Colon Carcinoma. Cancer Res 49: 816-820, 1989. 22) Ali S. Tiwari RM, Snow GB: False-positive and false-negative neck nodes, Head Neck Surg 8: 78-82, 1985. 3) Laurie GW, Leblond CP, Martin GR: Light microscopic immunolocalization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin in the basement membranes of a variety of rat organs. Am J Anat 167: 71-82, 1983. 42) Miettinen M, Virtanen I: Expression of laminin in thyroid gland and thyroid tumors: An immunohistologic study. Int J Cancer 34: 27-30, 1984. 47) Havenith MG, Zandvoort EHMV, Cleutjens JPM: Basement membrane deposition in benign and malignant naevomelanocytic lesions: An immunohistochemical study with antibodies to type IV collagen and laminin Histopathology 15: 137-145, 1989. 39) Szendröi M, Lapis K: Distribution of Fibronectin and Laminin in Human Liver Tumors. J Cancer Res Clin Oncol 109: 60-64, 1985. 23) Mendenhall WM, Million RR: Selective neck irradiation in squamous cell carcinoma of the head and neck. Head Neck Surg 3: 15-23, 1980. 34) Meyer JR, Silverman SJ, Daniels TE: Distribution of fibronectin and laminin in oral leukoplakia and carcinoma. J Oral Pathol 14: 247-255, 1985. 35) 野口誠, 小浜源郁, 平塚博義, 宮川明, 山口晃他: 口腔扁平上皮癌におけるlamininの局在様式と組織学的悪性度. 癌の臨床35: 880-885, 1989. 45) Auersperg N. Kruk PA. MacLaren IA: Heterogenous Expression of Keratin, and Extracellular Matrix among Subpopulation of a Poorly Differentiated Human Cervical Carcinoma: Possible Relationship to Patterns of Invasion. Cancer Res 49: 3007-3014, 1989. 9) Cam Y, Caulet T, Bellon G: Immunohistochemical localization of Macromolecules of the basement membrane and the peritumoral stroma in human laryngeal carcinomas, J Pathol 144: 35-44, 1984. 24) Brocks DG, Strecker H, Neubauer HP: Radioimmunoassay of Laminin in Serum and Its Application to Cancer Patients. Clin Chem 32: 787-791, 1986. |
| References_xml | – reference: 6) Charpin C, Lissitzky JC, Jacquemier J: Immunohistochemical Detection of Laminin in 98 Human Breast Carcinomas. A Light and Electron Microscopic Study. Human Pathology 17: 355-365, 1986. – reference: 48) Natali PG, Nicotra MR, Bellocci M: Distribution of laminin and collagen type IV in benign and malignant lesions of melanocytic origin. Int J Cancer 35: 461-467, 1985. – reference: 13) Vogel HP, Mendelsohn G: Laminin Immunostaining in Hyperplastic, Dysplastic, and Neoplastic Lesions of the Endometrium and Uterine Cervix. Obstetrics Gynecology 69: 794-799, 1987. – reference: 22) Ali S. Tiwari RM, Snow GB: False-positive and false-negative neck nodes, Head Neck Surg 8: 78-82, 1985. – reference: 41) Charpin C, Kopp F, Schneider NP: Laminin immunodetection in tumorous and non-tumorous disorders of human thyroid. Bull Cancer 72: 6-15, 1985. – reference: 28) Lah TT, Buck MR, Honn KV: Degradation of laminin by human tumor cathepsin B. Clin Expl Metastasis 7 (4): 461-468, 1989. – reference: 44) 橋本博, 黒田一秀, 坂下茂夫: 膀胱癌と基底膜特異蛋白laminin日泌尿会誌75: 580-590. 1984. – reference: 5) Liotta LA: Tumor invasion and metastasis. Role of the extracellular matrix. Rhoads memorial award lecture. Cancer Res 46: 1-7, 1986. – reference: 29) Hirota J, Yoneda K, Osaki T: Basement membrane type IV collagen in oral squamous cell carcinoma. HEAD & NECK, September/October: 400-405, 1990. – reference: 31) 鈴木守, 高坂知節, 粟田口敏一, 橋本省: 頭頸部癌組織内のラミニン, タイプ4コラーゲン, フィブロネクチンの分布, 頭頸部腫瘍16: 26-29, 1990. – reference: 12) Stenbäck F, Risteli J, Risteli L: Basement Membrane Laminin and Type IV Collagen in Endometrial Adenocarcinoma: Relation to Differentiation and Treatment. Oncology 42: 370-376, 1985. – reference: 15) Forster SJ, Talbot IC, Critchley DR: Laminin and fibronectin in rectal adenocarcinoma: Relationship to tumour grade, stage and metastasis, Br J Cancer 50: 51-61, 1984. – reference: 47) Havenith MG, Zandvoort EHMV, Cleutjens JPM: Basement membrane deposition in benign and malignant naevomelanocytic lesions: An immunohistochemical study with antibodies to type IV collagen and laminin Histopathology 15: 137-145, 1989. – reference: 8) 樋口真秀, 大西丘倫, 有田憲生, 平賀章〓, 岩崎弘充他: ヒト悪性グリオーマにおけるfibronectinおよびfibronectin-receptorの免疫組織化学的局在-腫瘍浸潤との関連より-脳神経43: 17-23, 1991. – reference: 32) Giordana MT, Germano I, Giaccone G: The Distribution of Laminin in Human Brain Tumors: An Immunohistochemical Study. Acta Neuropathol 67: 51-57, 1985. – reference: 37) 迎徹: 胃癌組織におけるFibronectin, Lamininの免疫組織学的検討. J Jpn Soc Cancer Ther 25: 2468-2476, 1990. – reference: 45) Auersperg N. Kruk PA. MacLaren IA: Heterogenous Expression of Keratin, and Extracellular Matrix among Subpopulation of a Poorly Differentiated Human Cervical Carcinoma: Possible Relationship to Patterns of Invasion. Cancer Res 49: 3007-3014, 1989. – reference: 21) Broders AC: Carcinoma. Grading and practical application. Arch Pathol 2: 376-381, 1926. – reference: 24) Brocks DG, Strecker H, Neubauer HP: Radioimmunoassay of Laminin in Serum and Its Application to Cancer Patients. Clin Chem 32: 787-791, 1986. – reference: 36) Takeda H: Immunohistochemical studies of basement membrane components in primary and metastatic lesions of early gastric cancer. J Nippon Med Sch 57: 160-171. 1990. – reference: 7) Joffe EBDK, Puricelli L, Mariotto R: Fibronectin and laminin expression in breast cancer and lymph node metastasis. Lack of correlation with fibronectin plasmatic levels. MEDICINA (Buenos Aires) 48: 499-505, 1988. – reference: 42) Miettinen M, Virtanen I: Expression of laminin in thyroid gland and thyroid tumors: An immunohistologic study. Int J Cancer 34: 27-30, 1984. – reference: 25) Dickneite G, Sedlacek HH, Timpl R: Tumor Growth and Metastasis Increases the Serum Concentration of Basement Membrane Proteins. Behring Inst Mitt 78: 159-166, 1985. – reference: 46) Daneker GW, Mercurio AM, Guerra L: Laminin Expression in Colorectal Carcinomas Varying in Degree of Differentiation. Arch Surg 122: 1470-1474, 1987. – reference: 26) Boyd D, Ziober B, Chakrabarty S: Examination of Urokinase Protein/Transcript Levels and Their Relationship with Laminin Degradation in Cultured Colon Carcinoma. Cancer Res 49: 816-820, 1989. – reference: 20) Jakobsson PA: Histologic grading of malignancy and prognosis in glottic carcinoma of the larynx. Centennial Conference on Laryngeal Cancer. New York: Appleton-Century-Crofts: 847-852, 1976. – reference: 23) Mendenhall WM, Million RR: Selective neck irradiation in squamous cell carcinoma of the head and neck. Head Neck Surg 3: 15-23, 1980. – reference: 33) Sugihara H, Hattori T, Fujita S: Distribution of fibronectin and laminin in early and advanced signet-ring-cell carcinomas of the stomach. Int J Cancer 43: 263-269, 1989. – reference: 38) Haglund C, Nordling S, Roberts PJ: Expression of laminin in pancreatic neoplasms and in chronic pancreatitis. Am J Surg Pathol 8: 669-676, 1984. – reference: 40) Sinha AA, Gleason DF, Wilson MJ: Immunohistochemical Localization of Laminin in the basement Membranes of Normal, Hyperplastic, and Neoplastic Human Prostate. The Prostate 15: 299-313, 1989. – reference: 3) Laurie GW, Leblond CP, Martin GR: Light microscopic immunolocalization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin in the basement membranes of a variety of rat organs. Am J Anat 167: 71-82, 1983. – reference: 10) Visser R, Beek JMHV, Havenith MG: Immunocytochemical detection of basement membrane antigens in the histopathological evaluation of laryngeal dysplasia and neoplasia. Histopathology 10: 171-180, 1986. – reference: 34) Meyer JR, Silverman SJ, Daniels TE: Distribution of fibronectin and laminin in oral leukoplakia and carcinoma. J Oral Pathol 14: 247-255, 1985. – reference: 4) Liotta LA, Rao CN, Barsky SH: Tumor invasion and the extracellular matrix. Lab Invest 49: 636-649, 1983. – reference: 35) 野口誠, 小浜源郁, 平塚博義, 宮川明, 山口晃他: 口腔扁平上皮癌におけるlamininの局在様式と組織学的悪性度. 癌の臨床35: 880-885, 1989. – reference: 9) Cam Y, Caulet T, Bellon G: Immunohistochemical localization of Macromolecules of the basement membrane and the peritumoral stroma in human laryngeal carcinomas, J Pathol 144: 35-44, 1984. – reference: 39) Szendröi M, Lapis K: Distribution of Fibronectin and Laminin in Human Liver Tumors. J Cancer Res Clin Oncol 109: 60-64, 1985. – reference: 43) Oguro K. Kazama T. Isemura M: Immunohistochemical Alterlations in Basement Membrane Components of Squamous Cell Carcinoma. J Invest Dermatol 96: 250-254, 1991 – reference: 2) Ekblom P, Miettinen M, Rapola J: Demonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues. Histochemistry 75: 301-307, 1982. – reference: 14) Forster SJ, Talbot IC, Clayton DJ: Tumor basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance. Int J Cancer 37: 813-817, 1986. – reference: 19) Crissman JD, Liu WY, Gluckman JL: Prognostic Value of Histopathologic Parameters in Squamous Cell Carcinoma of the Oropharynx. Cancer 54: 2995-3001, 1984. – reference: 17) McComb RD, Bigner DD: Immunolocalization of Laminin in Neoplasms of the Central and Peripheral Nervous Systems. J Neuropathol Exp Neurol 44: 242-253, 1985. – reference: 1) Foidert JM, Bere EWJ, Yaar M: Distribution and immunoelectron microscopic localization of laminin, a non-collagenous basement membrane glycoprotein. Lab Invest 42: 336-342, 1980. – reference: 30) 村上匡孝, 三牧三郎, 斎藤裕子, 和田義正, 西山康之他: 頭頸部扁平上皮癌巣周囲膜IV型コラゲンの免疫組織学的研究-生検組織の癌巣周囲膜と頸部リンパ節転移-, 日耳鼻95: 1773-1784, 1992. – reference: 16) Nishino T, Ishida T, Oka T: Prognostic Significance of Laminin in Adenocarcinoma of the Lung. J Surgical Oncology 43: 214-218, 1990. – reference: 11) Bulleti C, Galassi A, Jasonni VM: Basement Membrane Components in Normal, Hyperplastic and Neoplastic Endometrium. Cancer 62: 142-149, 1988. – reference: 27) Heck LW, Blackburn WD, Irwin MH: Degradation of Basement Membrane Laminin by Human Neutrophil Elastase and Cathepsin G. Am J Pathol 136 (6): 1267-1274, 1990. – reference: 18) Mori M, Shimono R, Kido A: Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study. Int J Cancer 47: 839-842, 1991. |
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| Snippet | 頭頸部扁平上皮癌組織におけるラミニンの分布を免疫組織染色にて調べたところ癌胞巣周囲に分布が認められたがその程度はさまざまであった. 癌胞巣周囲の染色様態を正常型, 断裂型, 消失型の3群に分類し臨床的悪性度, 角化度, 浸潤様式との関係を検討した. 断裂型, 消失型でリンパ節転移, リンパ節再発の率が有意に高かった.... |
| SourceID | jstage |
| SourceType | Publisher |
| StartPage | 216 |
| SubjectTerms | ラミニン 転移 頭頸部癌 |
| Subtitle | ラミニン染色性と臨床像, 病理組織像との関係 |
| Title | 頭頸部扁平上皮癌組織における基底膜糖タンパタラミニンの分布 |
| URI | https://www.jstage.jst.go.jp/article/jibiinkoka1947/98/2/98_2_216/_article/-char/ja |
| Volume | 98 |
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| ispartofPNX | 日本耳鼻咽喉科学会会報, 1995/02/20, Vol.98(2), pp.216-225,351 |
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