133Xe吸入による脳血流測定法の検討 本邦正常成人の脳血流値と脳内部位別差異について
非侵襲的脳血流測定法である133Xe吸入法により本邦成人の脳血流の正常値, 脳内部位別差異, 左右差などを測定し, また本法の臨床的応用が可能か否かを検討した.脳内に器質的病変を認めない19歳より92歳迄の右利き日本人成人20例, 男女各10名を対象とし, Novo社製32 channel cerebrographを用い一側脳半球平均および脳内32ヵ所のF1, ISI, FF1, W1を測定した.F1の右半球平均値は74.2±15.5ml/100g brain/min, 左74.3±15.3, ISIは右52.9±9.3, 左52.6±8.8であり, あきらかな左右差はみられなかった.平均脳半...
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| Published in | 脳卒中 Vol. 2; no. 4; pp. 364 - 371 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本脳卒中学会
25.12.1980
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| Online Access | Get full text |
| ISSN | 0912-0726 1883-1923 |
| DOI | 10.3995/jstroke.2.364 |
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| Abstract | 非侵襲的脳血流測定法である133Xe吸入法により本邦成人の脳血流の正常値, 脳内部位別差異, 左右差などを測定し, また本法の臨床的応用が可能か否かを検討した.脳内に器質的病変を認めない19歳より92歳迄の右利き日本人成人20例, 男女各10名を対象とし, Novo社製32 channel cerebrographを用い一側脳半球平均および脳内32ヵ所のF1, ISI, FF1, W1を測定した.F1の右半球平均値は74.2±15.5ml/100g brain/min, 左74.3±15.3, ISIは右52.9±9.3, 左52.6±8.8であり, あきらかな左右差はみられなかった.平均脳半球血流の左右差の1.96σ2はF1 6.1, ISI 3.3であるが個々の検出器の左右差の1.96σ2はF1 21.6, ISI 8.7であり, 本法による脳内局所の左右差の検討には慎重を要すると考えた.本法による脳内部位別血流をみると前頭部では平均血流より高値を, 後頭・頭頂・側頭部の一部では低値を推計学的に有意に示し, 閉眼覚醒安静状態においでも脳血流は脳内で不均等分布を呈することが明らかとなった. 1.本邦正常右利き成人20例 (平均年齢44歳) の脳血流を示す各種パラメータを133Xe吸入法により検討した。 2.脳半球平均血流は脳灰白質血流を主として表わすF1で右半球74.2±15.5ml/100g brain/min, 左半球74.3±15.3, Initial slope index (ISI) で右半球52.9±9.3, 左半球52.6±8.8であり, 左右差はみられない. 3.脳内各部位別にみると前頭部では平均血流より高値を, 後頭・頭頂・側頭部の一部では低値を推計学的にも有意に示し, 閉眼覚醒安静状態においても脳血流は均等な分布を呈さない事が明らかとなった. |
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| AbstractList | 非侵襲的脳血流測定法である133Xe吸入法により本邦成人の脳血流の正常値, 脳内部位別差異, 左右差などを測定し, また本法の臨床的応用が可能か否かを検討した.脳内に器質的病変を認めない19歳より92歳迄の右利き日本人成人20例, 男女各10名を対象とし, Novo社製32 channel cerebrographを用い一側脳半球平均および脳内32ヵ所のF1, ISI, FF1, W1を測定した.F1の右半球平均値は74.2±15.5ml/100g brain/min, 左74.3±15.3, ISIは右52.9±9.3, 左52.6±8.8であり, あきらかな左右差はみられなかった.平均脳半球血流の左右差の1.96σ2はF1 6.1, ISI 3.3であるが個々の検出器の左右差の1.96σ2はF1 21.6, ISI 8.7であり, 本法による脳内局所の左右差の検討には慎重を要すると考えた.本法による脳内部位別血流をみると前頭部では平均血流より高値を, 後頭・頭頂・側頭部の一部では低値を推計学的に有意に示し, 閉眼覚醒安静状態においでも脳血流は脳内で不均等分布を呈することが明らかとなった. 1.本邦正常右利き成人20例 (平均年齢44歳) の脳血流を示す各種パラメータを133Xe吸入法により検討した。 2.脳半球平均血流は脳灰白質血流を主として表わすF1で右半球74.2±15.5ml/100g brain/min, 左半球74.3±15.3, Initial slope index (ISI) で右半球52.9±9.3, 左半球52.6±8.8であり, 左右差はみられない. 3.脳内各部位別にみると前頭部では平均血流より高値を, 後頭・頭頂・側頭部の一部では低値を推計学的にも有意に示し, 閉眼覚醒安静状態においても脳血流は均等な分布を呈さない事が明らかとなった. |
| Author | 篠原, 幸人 高木, 繁治 小畠, 敬太郎 |
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| References | 5) Risberg J, Ali Z, Wilson EM et al : Regional cerebral blood flow by 133Xenon inhalation. Preliminary evaluation of an initial slope index in patients with unstable flow compartments, Stroke 6 : 142, 1975 3) Obrist WD, Thompson HK Jr, King CH et al : Determination of regional cerebral blood flow by inhalation of 133-Xenon, Circ Res 20 : 124, 1967 21) 後藤文男, 篠原幸人 : 脳循環・代謝と脳波, 臨床脳波15 : 203, 1973 2) Ingvar DH, Lassen NA : Regional blood flow of the cerebral cortex determined by Krypton85, Acta Physiol Scand 54 : 325, 1962 11) Shinohara Y, Meyer JS, Kitamura A et al : Measurement of cerebral hemispheric blood flow by intracarotid injection of hydrogen gas. Validation of the method in the monkey, Circ Res 25 : 735, 1969 6) Mallett BL, Veall N : Investigation of cerebral blood flow in hypertension using radioactive xenon inhalation and extracranial recording, Lancet 1 : 1081, 1963 7) Mallett BL, Veall N : The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording, Clin Sci 29 : 179, 1965 17) Wilkinson IMS, Bull JWD, DuBoulay GH et al : Regional blood flow in the normal cerebral hemisphere, J Neurol Neurosurg Psychiatry 32 : 367, 1969 18) Lassen NA, Roland PE, Larsen B et al : Mapping of human cerebral functions : A study of the regional cerebral blood flow pattern during rest, its reproducibility and the activations seen during basic sensory and motor functions, Acta Neurol Scand 56 (Suppl 64) : 262, 1977 12) Blauenstein UW, Halsey JH Jr, Wilson EM et al : 133Xenon inhalation method : Significance of indicator maldistribution for distinguishing brain areas with impaired perfusion. An index for total flow, Stroke 9 : 57, 1978 15) Corbett JL, Eidelman BH : A comparison of three isotope inhalation techniques for cerebral blood flow measurement and the arteriovenous oxygen content difference method, In Langfitt TW et al eds “Cerebral Circulation and Metabolism”, New York, Springer Verlag, 1975, p 394 10) Meyer JS, Shinohara Y : A method for measuring cerebral hemispheric blood flow and metabolism, Stroke 1 : 419, 1970 1) Lassen NA, Ingvar DH : Blood flow of the cerebral cortex determined by radioactive Krypton85, Experimentia 17 : 42, 1961 8) Kety SS : The theory and applications of the exchange of inert gas at the lungs and tissues, Pharmacol Rev 3 : 1, 1951 19) Ingvar DH : “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state, Acta Neurol Scand 60 : 12, 1979 16) Blauenstein UW, Halsey JH Jr, Wilson EM et al : 133Xenon inhalation method. Analysis of reproducibility : Some of its physiological implications, Stroke 8 : 92, 1977 14) McHenry LC Jr, Merory J, Bass E et al : Xenon-133 inhalation method for regional cerebral blood flow measurements : Normal values and test-retest results, Stroke 9 : 396, 1978 13) Meyer JS, Ishihara N, Deshmukh VD et al : Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation. Part I : Description of method and normal values obtained in healthy volunteers, Stroke 9 : 195, 1978 4) Obrist WD, Thompson HK Jr, Wang HS et al : Regional cerebral blood flow estimated by 133Xenon inhalation, Stroke 6 : 245, 1975 9) Gotoh F, Meyer JS, Tomita M : Hydrogen method for determining cerebral blood flow in man, Arch Neurol 15 : 549, 1966 20) Roy CS, Sherrington CS : On the regulation of the blood supply of the brain, J Physiol 11 : 85, 1890 |
| References_xml | – reference: 17) Wilkinson IMS, Bull JWD, DuBoulay GH et al : Regional blood flow in the normal cerebral hemisphere, J Neurol Neurosurg Psychiatry 32 : 367, 1969 – reference: 3) Obrist WD, Thompson HK Jr, King CH et al : Determination of regional cerebral blood flow by inhalation of 133-Xenon, Circ Res 20 : 124, 1967 – reference: 11) Shinohara Y, Meyer JS, Kitamura A et al : Measurement of cerebral hemispheric blood flow by intracarotid injection of hydrogen gas. Validation of the method in the monkey, Circ Res 25 : 735, 1969 – reference: 4) Obrist WD, Thompson HK Jr, Wang HS et al : Regional cerebral blood flow estimated by 133Xenon inhalation, Stroke 6 : 245, 1975 – reference: 6) Mallett BL, Veall N : Investigation of cerebral blood flow in hypertension using radioactive xenon inhalation and extracranial recording, Lancet 1 : 1081, 1963 – reference: 10) Meyer JS, Shinohara Y : A method for measuring cerebral hemispheric blood flow and metabolism, Stroke 1 : 419, 1970 – reference: 18) Lassen NA, Roland PE, Larsen B et al : Mapping of human cerebral functions : A study of the regional cerebral blood flow pattern during rest, its reproducibility and the activations seen during basic sensory and motor functions, Acta Neurol Scand 56 (Suppl 64) : 262, 1977 – reference: 19) Ingvar DH : “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state, Acta Neurol Scand 60 : 12, 1979 – reference: 5) Risberg J, Ali Z, Wilson EM et al : Regional cerebral blood flow by 133Xenon inhalation. Preliminary evaluation of an initial slope index in patients with unstable flow compartments, Stroke 6 : 142, 1975 – reference: 12) Blauenstein UW, Halsey JH Jr, Wilson EM et al : 133Xenon inhalation method : Significance of indicator maldistribution for distinguishing brain areas with impaired perfusion. An index for total flow, Stroke 9 : 57, 1978 – reference: 15) Corbett JL, Eidelman BH : A comparison of three isotope inhalation techniques for cerebral blood flow measurement and the arteriovenous oxygen content difference method, In Langfitt TW et al eds “Cerebral Circulation and Metabolism”, New York, Springer Verlag, 1975, p 394 – reference: 20) Roy CS, Sherrington CS : On the regulation of the blood supply of the brain, J Physiol 11 : 85, 1890 – reference: 7) Mallett BL, Veall N : The measurement of regional cerebral clearance rates in man using xenon-133 inhalation and extracranial recording, Clin Sci 29 : 179, 1965 – reference: 9) Gotoh F, Meyer JS, Tomita M : Hydrogen method for determining cerebral blood flow in man, Arch Neurol 15 : 549, 1966 – reference: 1) Lassen NA, Ingvar DH : Blood flow of the cerebral cortex determined by radioactive Krypton85, Experimentia 17 : 42, 1961 – reference: 13) Meyer JS, Ishihara N, Deshmukh VD et al : Improved method for noninvasive measurement of regional cerebral blood flow by 133Xenon inhalation. Part I : Description of method and normal values obtained in healthy volunteers, Stroke 9 : 195, 1978 – reference: 21) 後藤文男, 篠原幸人 : 脳循環・代謝と脳波, 臨床脳波15 : 203, 1973 – reference: 8) Kety SS : The theory and applications of the exchange of inert gas at the lungs and tissues, Pharmacol Rev 3 : 1, 1951 – reference: 14) McHenry LC Jr, Merory J, Bass E et al : Xenon-133 inhalation method for regional cerebral blood flow measurements : Normal values and test-retest results, Stroke 9 : 396, 1978 – reference: 2) Ingvar DH, Lassen NA : Regional blood flow of the cerebral cortex determined by Krypton85, Acta Physiol Scand 54 : 325, 1962 – reference: 16) Blauenstein UW, Halsey JH Jr, Wilson EM et al : 133Xenon inhalation method. Analysis of reproducibility : Some of its physiological implications, Stroke 8 : 92, 1977 |
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| Snippet | 非侵襲的脳血流測定法である133Xe吸入法により本邦成人の脳血流の正常値, 脳内部位別差異, 左右差などを測定し, また本法の臨床的応用が可能か否かを検討した.脳内に器質的病変を認めない19歳より92歳迄の右利き日本人成人20例, 男女各10名を対象とし, Novo社製32 channel... |
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| Subtitle | 本邦正常成人の脳血流値と脳内部位別差異について |
| Title | 133Xe吸入による脳血流測定法の検討 |
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