Mathematical Modeling of Genistein's Inhibitory Effects on the Tryptophan Pathway: Enzyme Blockage and NAD Dynamics

• Published in: 2024 2nd International Conference on Signal Processing, Communication, Power and Embedded System (SCOPES) pp. 1 - 6
• Main Authors: Bhattacharjee, Sudipa, Bhadra, Preetha
• Format: Conference Proceeding
• Language: English
• Published: IEEE 19.12.2024
• Subjects: 3-dioxygenase (IDO); Analytical models; Diseases; Embedded systems; Enzymes; Flux balance analysis (FBA); Genistein; Indoleamine 2; Kynurenine pathway; Mathematical modelling; Mathematical models; Metabolism; NAD+ synthesis; Neurodegenerative diseases; Production; Signal processing; Simulation; Steady-state; Tryptophan metabolism

The kynurenine pathway (KP) is a crucial route for tryptophan metabolism, leading to NAD+ production and having a significant role in neurodegenerative disorders. This work examines the effects of genistein, a bioactive isoflavone from soybeans, on the KP using a mathematical model. It focuses on th...