Dual mode Photothermal/Photodynamic transduction studies using Multifunctional nanosystem for Biomedical Applications

• Published in: 2024 IEEE 5th India Council International Subsections Conference (INDISCON) pp. 1 - 4
• Main Authors: Ali, Mohammad Sadik, Patnam, Sreekanth, Rengan, Aravind Kumar
• Format: Conference Proceeding
• Language: English
• Published: IEEE 22.08.2024
• Subjects: Biological cells; Cancer; Chlorin e6; Combination therapy; Drugs; Iodine compounds; IR780 iodide; Nanotechnology; Optimization; Radiation effects; Safety; synergistic effect; Thermal stability; Tumors
• DOI: 10.1109/INDISCON62179.2024.10744306

The study presents the development and characterization of a new nanosystem, IR780 iodide liposome-coated chlorin e6 nanoemulsions (IR780lipo@CLNE), designed for dual photothermal and photodynamic therapy (PTT and PDT) in cancer treatment. Investigating this nanosystem under near-infrared (NIR) irradiation provides valuable insights into its physical properties and behavior. Combining IR780 iodide and chlorin e6 within the nanosystem enhances therapeutic efficacy compared to individual photosensitizers, owing to the synergistic effects of PTT and PDT, resulting in improved cancer cell death. Nanotechnology aids in optimizing the delivery of hydrophobic drugs to the tumor site, enhancing efficacy and safety. Liposome-coated nanoemulsions enable targeted delivery and accumulation of photosensitizers at the tumor site, minimizing off-target effects. The nanosystem exhibits excellent photothermal stability, sustaining temperature increases upon NIR irradiation, which is crucial for effective PTT while minimizing damage to healthy tissues. Moreover, significant reactive oxygen species (ROS) generation upon NIR irradiation highlights the nanosystem's potential for effective PDT. Despite ROS generation being slightly lower than chlorin e6 alone, the combined PTT and PDT effects enhance cancer cell killing. Overall, the study underscores the promise of the IR780lipo@CLNE nanosystem as a versatile platform for synergistic cancer therapy. Further optimization and preclinical studies are warranted to fully explore its therapeutic potential for clinical translation.