A robustness analysis of eukaryotic cell cycle concerning Cdc25 and wee1 proteins

• Published in: 2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control pp. 1734 - 1739
• Main Authors: Azuma, T., Moriya, H., Matsumuro, H., Kitano, H.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 01.10.2006
• Subjects: Analytical models; Biological system modeling; Cancer; Chemicals; Mathematical model; Protein engineering; Robust control; Robustness; Sensitivity analysis; Systems biology
• DOI: 10.1109/CACSD-CCA-ISIC.2006.4776903
• ISSN: 2165-3011

This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference