A robustness analysis of eukaryotic cell cycle concerning Cdc25 and wee1 proteins

This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that...

Full description

Saved in:
Bibliographic Details
Published in2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control pp. 1734 - 1739
Main Authors Azuma, T., Moriya, H., Matsumuro, H., Kitano, H.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2006
Subjects
Analytical models
Biological system modeling
Cancer
Chemicals
Mathematical model
Protein engineering
Robust control
Robustness
Sensitivity analysis
Systems biology
Online AccessGet full text

Cover

More Information
Summary:This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference
ISSN:2165-3011
2165-302X
DOI:10.1109/CACSD-CCA-ISIC.2006.4776903