A Novel Strategy for Designing Dual-Target Inhibitors of KU86 and XRCC4

• Published in: 2009 2nd International Conference on Biomedical Engineering and Informatics pp. 1 - 4
• Main Authors: Chien-Yu Chen, Fuu-Jen Tsai, Jing-Gung Chung, Chang-Hai Tsai, Yuan-Man Hsu, Hung-Jin Huang, Tin-Yun Ho, Yea-Huey Chang, Da-Tian Bau, Ming-Hsui Tsai, Chen, C.Y.-C.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 01.10.2009
• Subjects: Asia; Bioinformatics; Cancer; DNA; Drugs; Hospitals; Humans; Inhibitors; Proteins

This is the first time that we reported about dual target inhibitors of KU86 and XRCC4. XRCC4 was well known as the downstream of KU86-DNA complex. They both play an important role in the DNA double-strain breaks (DSBs) repair system subpathway, non-homologous end joining (NHEJ).In this study, The p...