Distribution of nucleosome binding motifs around the functional sites of human housekeeping genes

The positioning of nucleosome on underlying DNA plays an important role in the regulation of every process that occurs on DNA. We plotted out the nucleosome binding motifs around the functional sites of housekeeping genes and compared the similarities and differences with ensemble genes. We found th...

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Bibliographic Details
Published in2012 5th International Conference on Biomedical Engineering and Informatics pp. 876 - 879
Main Authors Bao, Tonglaga, Li, Hong, Zhao, Xiaoqing
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.10.2012
Subjects
8-mer distribution
Bioinformatics
Codons
DNA sequencing
Elongation
functional sites
Mathematical models
nucleosome array
nucleosome binding motifs
Proteins
Radio frequency
Regulation
Shape
Translation
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Summary:The positioning of nucleosome on underlying DNA plays an important role in the regulation of every process that occurs on DNA. We plotted out the nucleosome binding motifs around the functional sites of housekeeping genes and compared the similarities and differences with ensemble genes. We found that housekeeping genes show stronger preference than ensemble genes. Proportion of nucleosome binding motifs in the transcription start region is higher than other functional sites. Our result confirmed the idea that nucleosomes are distributed not uniformly along the genomic DNA and more nucleosome binding signal existed in the transcription start region to facilitated gene transcription and expression.
ISBN:9781467311830
1467311839
DOI:10.1109/BMEI.2012.6513116